Publications by authors named "Jacob Plattner"

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Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.
David S Carter, Robert T Jacobs, Yvonne R Freund, Pamela W Berry, Tsutomu Akama, Jacob J Plattner

ACS Infect Dis· February 2020

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Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
Tsutomu Akama, Yvonne R Freund, Pamela W Berry, David S Carter, Eric E Easom, Jacob J Plattner

ACS Infect Dis· February 2020

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In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Jacob J Plattner

PLoS Negl Trop Dis· January 2020

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Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
Kirthana M V Sindhe, Wesley Wu, Jenny Legac, Yong-Kang Zhang, Eric E Easom, Jacob J Plattner

mBio· January 2020

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Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.
Christopher S Lunde, Erin E Stebbins, Rajiv S Jumani, Md Mahmudul Hasan, Peter Miller, Jacob J Plattner

Nat Commun· June 2019

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Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Jacob J Plattner

J Med Chem· March 2019

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Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.
Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Jacob J Plattner

Antimicrob Agents Chemother· May 2018

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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Tsutomu Akama, Yong-Kang Zhang, Yvonne R Freund, Pamela Berry, Joanne Lee, Jacob J Plattner

Bioorg Med Chem Lett· January 2018

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Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
Xianfeng Li, Vincent Hernandez, Fernando L Rock, Wai Choi, Yvonne S L Mak, Jacob J Plattner

J Med Chem· October 2017

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Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
Yong-Kang Zhang, Jacob J Plattner, Eric E Easom, Robert T Jacobs, Denghui Guo

J Med Chem· July 2017

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Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Andrés Palencia, Xianfeng Li, Wei Bu, Wai Choi, Charles Z Ding, Jacob J Plattner

Antimicrob Agents Chemother· October 2016

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Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide.
Yong-Kang Zhang, Jacob J Plattner, Eric E Easom, Tsutomu Akama, Yasheen Zhou

Bioorg Med Chem Lett· July 2016

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Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide.
Yong-Kang Zhang, Jacob J Plattner, Eric E Easom, Yasheen Zhou, Tsutomu Akama

Bioorg Med Chem Lett· December 2015

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Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Yong-Kang Zhang, Jacob J Plattner, Eric E Easom, Robert T Jacobs, Denghui Guo

J Med Chem· July 2015

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From the Test Tube to the Treatment Room: Fundamentals of Boron-containing Compounds and their Relevance to Dermatology.
James Q Del Rosso, Jacob J Plattner

J Clin Aesthet Dermatol· February 2014

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Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.
Tsutomu Akama, Chen Dong, Charlotte Virtucio, Yvonne R Freund, Daitao Chen, Jacob J Plattner

Bioorg Med Chem Lett· November 2013

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An assessment of the genetic toxicology of novel boron-containing therapeutic agents.
Vic Ciaravino, Jacob Plattner, Sanjay Chanda

Environ Mol Mutagen· June 2013

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Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Vincent Hernandez, Thibaut Crépin, Andrés Palencia, Stephen Cusack, Tsutomu Akama, Jacob J Plattner

Antimicrob Agents Chemother· March 2013

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Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.
Tsutomu Akama, Charlotte Virtucio, Chen Dong, Richard Kimura, Yong-Kang Zhang, Jacob J Plattner

Bioorg Med Chem Lett· March 2013

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Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone.
Xianfeng Li, Yong-Kang Zhang, Jacob J Plattner, Weimin Mao, M R K Alley

Bioorg Med Chem Lett· February 2013

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Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Xianfeng Li, Yang Liu, Yong-Kang Zhang, Jacob J Plattner, Stephen J Baker

Bioorg Med Chem Lett· December 2012

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Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
Yvonne R Freund, Tsutomu Akama, M R K Alley, Joana Antunes, Chen Dong, Jacob J Plattner

FEBS Lett· September 2012

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Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease.
Maosheng Duan, Wieslaw Kazmierski, Renae Crosby, Margaret Gartland, Jinjing Ji, Jacob J Plattner

Bioorg Med Chem Lett· April 2012

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Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Wieslaw M Kazmierski, Robert Hamatake, Maosheng Duan, Lois L Wright, Gary K Smith, Jacob J Plattner

J Med Chem· April 2012

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Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Yong-Kang Zhang, Jacob J Plattner, Yvonne R Freund, Eric E Easom, Yasheen Zhou

Bioorg Med Chem Lett· February 2012

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