Publications by authors named "Jacob Poehlsgaard"

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Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.
Niels Møller Andersen, Jacob Poehlsgaard, Ralf Warrass, Stephen Douthwaite

Antimicrob Agents Chemother· November 2012

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Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.
Jacob Poehlsgaard, Niels M Andersen, Ralf Warrass, Stephen Douthwaite

ACS Chem Biol· August 2012

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A robust force field based method for calculating conformational energies of charged drug-like molecules.
Jacob Poehlsgaard, Kasper Harpsøe, Flemming Steen Jørgensen, Lars Olsen

J Chem Inf Model· February 2012

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Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.
Katherine S Long, Jacob Poehlsgaard, Lykke H Hansen, Sven N Hobbie, Erik C Böttger

Mol Microbiol· March 2009

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Modifications in Thermus thermophilus 23 S ribosomal RNA are centered in regions of RNA-RNA contact.
Jonas Mengel-Jørgensen, Søren Skov Jensen, Anette Rasmussen, Jacob Poehlsgaard, Jens Jørgen Lønsmann Iversen

J Biol Chem· August 2006

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The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics.
Katherine S Long, Jacob Poehlsgaard, Corinna Kehrenberg, Stefan Schwarz, Birte Vester

Antimicrob Agents Chemother· July 2006

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The bacterial ribosome as a target for antibiotics.
Jacob Poehlsgaard, Stephen Douthwaite

Nat Rev Microbiol· November 2005

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The archaeon Haloarcula marismortui has few modifications in the central parts of its 23S ribosomal RNA.
Finn Kirpekar, Lykke H Hansen, Anette Rasmussen, Jacob Poehlsgaard, Birte Vester

J Mol Biol· May 2005

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Molecular mechanisms by which rRNA mutations confer resistance to clindamycin.
Jacob Poehlsgaard, Peter Pfister, Erik C Böttger, Stephen Douthwaite

Antimicrob Agents Chemother· April 2005

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Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.
Märit Pringle, Jacob Poehlsgaard, Birte Vester, Katherine S Long

Mol Microbiol· December 2004

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The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.
Peter Pfister, Simon Jenni, Jacob Poehlsgaard, Ashley Thomas, Stephen Douthwaite

J Mol Biol· October 2004

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Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.
Guy W Novotny, Lene Jakobsen, Niels M Andersen, Jacob Poehlsgaard, Stephen Douthwaite

Antimicrob Agents Chemother· October 2004

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The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.
Stephen Douthwaite, Pamela F Crain, Mingfu Liu, Jacob Poehlsgaard

J Mol Biol· April 2004

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Macrolide antibiotic interaction and resistance on the bacterial ribosome.
Jacob Poehlsgaard, Stephen Douthwaite

Curr Opin Investig Drugs· February 2003

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The macrolide binding site on the bacterial ribosome.
Jacob Poehlsgaard, Stephen Douthwaite

Curr Drug Targets Infect Disord· March 2002

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