Publications by authors named "Jacob S Lewis"

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nCas9-based method for rolling-circle DNA substrate generation.
Nischal Sharma, Kelsey S Whinn, Harshad Ghodke, Antoine M van Oijen, Jacob S Lewis

Anal Biochem· August 2025

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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes.
Nicholas Kusi-Appauh, Stefan H Mueller, Stephen F Ralph, Olga Yurieva, Michael E O'Donnell, Jacob S Lewis

J Vis Exp· April 2025

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Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis

Nat Struct Mol Biol· November 2024

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Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis

Nat Struct Mol Biol· August 2024

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Embracing Heterogeneity: Challenging the Paradigm of Replisomes as Deterministic Machines.
Jacob S Lewis, Antoine M van Oijen, Lisanne M Spenkelink

Chem Rev· December 2023

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Production of long linear DNA substrates with site-specific chemical lesions for single-molecule replisome studies.
Gurleen Kaur, Lisanne M Spenkelink, Jacob S Lewis, Slobodan Jergic, Nicholas E Dixon

Methods Enzymol· August 2022

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Mechanism of replication origin melting nucleated by CMG helicase assembly.
Jacob S Lewis, Marta H Gross, Joana Sousa, Sarah S Henrikus, Julia F Greiwe

Nature· June 2022

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Thermal interface materials with graphene fillers: review of the state of the art and outlook for future applications.
Jacob S Lewis, Timothy Perrier, Zahra Barani, Fariborz Kargar, Alexander A Balandin

Nanotechnology· April 2021

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Replisome bypass of a protein-based R-loop block by Pif1.
Grant D Schauer, Lisanne M Spenkelink, Jacob S Lewis, Olga Yurieva, Stefan H Mueller

Proc Natl Acad Sci U S A· December 2020

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A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome.
Enrico Monachino, Slobodan Jergic, Jacob S Lewis, Zhi-Qiang Xu, Allen T Y Lo

Mol Cell· July 2020

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Caught in the act: structural dynamics of replication origin activation and fork progression.
Jacob S Lewis, Alessandro Costa

Biochem Soc Trans· June 2020

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Design of customizable long linear DNA substrates with controlled end modifications for single-molecule studies.
Stefan H Mueller, Lisanne M Spenkelink, Antoine M van Oijen, Jacob S Lewis

Anal Biochem· March 2020

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Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication.
Jacob S Lewis, Lisanne M Spenkelink, Grant D Schauer, Olga Yurieva, Stefan H Mueller

Mol Cell· January 2020

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Nuclease dead Cas9 is a programmable roadblock for DNA replication.
Kelsey S Whinn, Gurleen Kaur, Jacob S Lewis, Grant D Schauer, Stefan H Mueller

Sci Rep· September 2019

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Recycling of single-stranded DNA-binding protein by the bacterial replisome.
Lisanne M Spenkelink, Jacob S Lewis, Slobodan Jergic, Zhi-Qiang Xu, Andrew Robinson

Nucleic Acids Res· May 2019

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Spatial and temporal organization of RecA in the DNA-damage response.
Harshad Ghodke, Bishnu P Paudel, Jacob S Lewis, Slobodan Jergic, Kamya Gopal

Elife· February 2019

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Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA.
Gurleen Kaur, Jacob S Lewis, Antoine M van Oijen

Molecules· January 2019

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Thermal Percolation Threshold and Thermal Properties of Composites with High Loading of Graphene and Boron Nitride Fillers.
Fariborz Kargar, Zahra Barani, Ruben Salgado, Bishwajit Debnath, Jacob S Lewis

ACS Appl Mater Interfaces· October 2018

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Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination.
Harshad Ghodke, Jacob S Lewis, Antoine M van Oijen

Trends Biochem Sci· March 2018

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Single-molecule visualization of leading-strand synthesis reveals dynamic interaction between MTC and the replisome.
Jacob S Lewis, Lisanne M Spenkelink, Grant D Schauer, Flynn R Hill, Roxanna E Georgescu

Proc Natl Acad Sci U S A· October 2017

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Single-molecule visualization of fast polymerase turnover in the bacterial replisome.
Jacob S Lewis, Lisanne M Spenkelink, Slobodan Jergic, Elizabeth A Wood, Enrico Monachino

Elife· April 2017

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