Publications by authors named "Jacques Deguine"

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Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.
Jinjin Xu, Lingjia Kong, Elizabeth A Creasey, Sneha Rath, Lei Deng, Jacques Deguine

J Exp Med· November 2025

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Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation.
Peng Tan, Alok Jaiswal, Shane P Murphy, Eric M Brown, Hailey Wheeler, Jacques Deguine

Science· October 2025

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A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
Kamil Slowikowski, Pritha Sen, Christopher V Cosgriff, Jessica Tantivit, Tom Eisenhaure, Jacques Deguine

medRxiv· September 2025

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Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.
Rocky M Barilla, Clara Berard, Linyu Sun, Sumiti Sandhu, Sarah Zaghouani, Jacques Deguine

Science· July 2025

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Single-cell and spatial transcriptomics of stricturing Crohn's disease highlights a fibrosis-associated network.
Lingjia Kong, Sathish Subramanian, Åsa Segerstolpe, Vy Tran, Angela R Shih, Jacques Deguine

Nat Genet· July 2025

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Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution.
Brianna R Watson, Biplab Paul, Raza Ur Rahman, Liat Amir-Zilberstein, Åsa Segerstolpe, Jacques Deguine

Nat Commun· January 2025

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B cell tolerance and autoimmunity: Lessons from repertoires.
Jacques Deguine, Ramnik J Xavier

J Exp Med· September 2024

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An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission.
Jiarui Ding, John J Garber, Amiko Uchida, Ariel Lefkovith, Grace T Carter, Jacques Deguine

Nat Commun· April 2024

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The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T Carter, Elizabeth A Creasey, Jacques Deguine

Immunity· December 2023

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A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells.
Alina Ulezko Antonova, Silvia Lonardi, Matilde Monti, Francesco Missale, Changxu Fan, Jacques Deguine

Proc Natl Acad Sci U S A· December 2023

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Multi-modal skin atlas identifies a multicellular immune-stromal community associated with altered cornification and specific T cell expansion in atopic dermatitis.
Evgenij Fiskin, Gökcen Eraslan, Maria B Alora-Palli, Juan Manuel Leyva-Castillo, Sean Kim, Jacques Deguine

bioRxiv· October 2023

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Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.
Jinjin Xu, Lingjia Kong, Blayne A Oliver, Bihua Li, Elizabeth A Creasey, Jacques Deguine

Cell Rep· July 2023

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Identification of host regulators of Mycobacterium tuberculosis phenotypes uncovers a role for the MMGT1-GPR156 lipid droplet axis in persistence.
Haroon Kalam, Chih-Hung Chou, Motohiko Kadoki, Daniel B Graham, Jacques Deguine

Cell Host Microbe· June 2023

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A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma.
Jehan Alladina, Neal P Smith, Tristan Kooistra, Kamil Slowikowski, Isabela J Kernin, Jacques Deguine

Sci Immunol· May 2023

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Remodeling of colon plasma cell repertoire within ulcerative colitis patients.
Johannes F Scheid, Basak Eraslan, Andrew Hudak, Eric M Brown, Dallis Sergio, Jacques Deguine

J Exp Med· April 2023

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The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T Carter, Elizabeth A Creasey, Jacques Deguine

Immunity· February 2023

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Functional analyses and single cell immunoprofiling uncover sex-specific differences in SARS-CoV2 immune memory development.
Basak Eraslan, Eric Brown, Maura Benson, Liat Amir-Zilberstein, Sung-Moo Park, Jacques Deguine

Res Sq· March 2022

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV.
Johannes F Scheid, Christopher O Barnes, Basak Eraslan, Andrew Hudak, Jennifer R Keeffe, Jacques Deguine

Cell· June 2021

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Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.
Carolyn M Walsh, Rose Z Hill, Jamie Schwendinger-Schreck, Jacques Deguine, Emily C Brock

Elife· October 2019

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First Encounters.
Jacques Deguine

Cell· October 2018

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A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns.
April E Price, Kiarash Shamardani, Kyler A Lugo, Jacques Deguine, Allison W Roberts

Immunity· September 2018

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New Flavors in Immunomodulation.
Jacques Deguine

Cell· June 2018

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To Each his Own.
Jacques Deguine

Trends Immunol· April 2018

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Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells.
Allison W Roberts, Bettina L Lee, Jacques Deguine, Shinu John, Mark J Shlomchik

Immunity· November 2017

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Common Senses.
Jacques Deguine

Trends Immunol· October 2017

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