Publications by authors named "Jacques Simard"

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Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women.
Peh Joo Ho, Christine Kim Yan Loo, Ryan Jak Yang Lim, Meng Huang Goh, Mustapha Abubakar, Jacques Simard

Cancers (Basel)· November 2025

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Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Jacques Simard

NPJ Genom Med· November 2025

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Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population.
Lorenzo Ficorella, Xin Yang, Nasim Mavaddat, Tim Carver, Hend Hassan, Jacques Simard

Br J Cancer· October 2025

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Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jacques Simard

Nat Commun· September 2025

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Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers.
Mei-Chee Tai, Joe Dennis, Sue K Park, Sung-Won Kim, Jong Won Lee, Jacques Simard

NPJ Breast Cancer· September 2025

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Psychological and emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: Findings from PERSPECTIVE I&I.
Laurence Lambert-Côté, Annie Turgeon, Kristina M Blackmore, Amy Chang, Antonis C Antoniou, Jacques Simard

Genet Med· August 2025

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Structural equation modeling of factors influencing women's attitudes, comfort and willingness toward risk-stratified breast cancer screening.
Cynthia Mbuya-Bienge, Nora Pashayan, Jacques Simard, Hermann Nabi

Sci Rep· July 2025

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Evaluating the performance of the Breast and Ovarian Analysis of Disease Incidence Algorithm model in predicting 10-year breast cancer risks in UK Biobank.
Carmen Petitjean, Naomi Wilcox, Lorenzo Ficorella, Joe Dennis, Jonathan Tyrer, Jacques Simard

J Natl Cancer Inst· May 2025

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Primary care providers' experience and satisfaction with personalised breast cancer screening risk communication: a descriptive cross-sectional study.
Arian Omeranovic, Julie Lapointe, Philippe Fortier, Anne-Sophie Bergeron, Michel Dorval, Jacques Simard

BMJ Open· May 2025

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Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestries.
Peh Joo Ho, Christine Kim Yan Loo, Meng Huang Goh, Mustapha Abubakar, Thomas U Ahearn, Jacques Simard

medRxiv· March 2025

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Genetic discrimination in insurance and employment based on personalized risk stratification for breast cancer screening.
Manuela Reveiz, Sarah Bouhouita-Guermech, Kristina M Blackmore, Jocelyne Chiquette, Éric Demers, Jacques Simard

Front Genet· March 2025

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Barriers and Facilitators to Delivering Multifactorial Risk Assessment and Communication for Personalized Breast Cancer Screening: A Qualitative Study Exploring Implementation in Canada.
Meghan J Walker, Anna Neely, Antonis C Antoniou, Mireille J M Broeders, Jennifer D Brooks, Jacques Simard

Curr Oncol· March 2025

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Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer.
Reiner Hoppe, Stefan Winter, Wing-Yee Lo, Kyriaki Michailidou, Manjeet K Bolla, Jacques Simard

NPJ Breast Cancer· February 2025

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Correction: Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model.
Nasim Mavaddat, Lorenzo Ficorella, Tim Carver, Andrew Lee, Alex P Cunningham, Jacques Simard

Cancer Epidemiol Biomarkers Prev· January 2025

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Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction.
Kristia Yiangou, Nasim Mavaddat, Joe Dennis, Maria Zanti, Qin Wang, Jacques Simard

Breast Cancer Res· December 2024

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Evaluating Real World Health System Resource Utilization and Costs for a Risk-Based Breast Cancer Screening Approach in the Canadian PERSPECTIVE Integration and Implementation Project.
Soo-Jin Seung, Nicole Mittmann, Zharmaine Ante, Ning Liu, Kristina M Blackmore, Jacques Simard

Cancers (Basel)· September 2024

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Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in the Population Setting: Challenges and Opportunities.
Meghan J Walker, Kristina M Blackmore, Amy Chang, Laurence Lambert-Côté, Annie Turgeon, Jacques Simard

Cancers (Basel)· May 2024

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Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk.
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Jacques Simard

medRxiv· March 2024

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Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction.
Kristia Yiangou, Nasim Mavaddat, Joe Dennis, Maria Zanti, Qin Wang, Jacques Simard

medRxiv· February 2024

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Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel.
Hagai Levi, Shai Carmi, Saharon Rosset, Rinat Yerushalmi, Aviad Zick, Jacques Simard

J Med Genet· November 2023

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Author Correction: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.
Naomi Wilcox, Martine Dumont, Anna González-Neira, Sara Carvalho, Charles Joly Beauparlant, Jacques Simard

Nat Genet· November 2023

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A Systematic Review and Critical Assessment of Breast Cancer Risk Prediction Tools Incorporating a Polygenic Risk Score for the General Population.
Cynthia Mbuya-Bienge, Nora Pashayan, Cornelia D Kazemali, Julie Lapointe, Jacques Simard

Cancers (Basel)· November 2023

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Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer.
Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Jacques Simard

Eur J Epidemiol· October 2023

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Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.
Naomi Wilcox, Martine Dumont, Anna González-Neira, Sara Carvalho, Charles Joly Beauparlant, Jacques Simard

Nat Genet· September 2023

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Canadian Healthcare Professionals' Views and Attitudes toward Risk-Stratified Breast Cancer Screening.
Julie Lapointe, Jean-Martin Côté, Cynthia Mbuya-Bienge, Michel Dorval, Nora Pashayan, Jacques Simard

J Pers Med· June 2023

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