Publications by authors named "Jake A Melby"

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Small-Scale Serial Size Exclusion Chromatography (sSEC) for High Sensitivity Top-Down Proteomics of Large Proteoforms.
Holden T Rogers, Jake A Melby, Lauren E Ehlers, Matthew S Fischer, Eli J Larson

Anal Chem· February 2024

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Lactate- and immunomagnetic-purified hiPSC-derived cardiomyocytes generate comparable engineered cardiac tissue constructs.
Kalina J Rossler, Willem J de Lange, Morgan W Mann, Timothy J Aballo, Jake A Melby

JCI Insight· January 2024

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Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics.
Emily A Chapman, David S Roberts, Timothy N Tiambeng, Jãán Andrews, Man-Di Wang, Jake A Melby

Nat Commun· December 2023

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Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics.
Holden T Rogers, David S Roberts, Eli J Larson, Jake A Melby, Kalina J Rossler

Anal Chem· September 2023

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Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics.
Emily A Chapman, David S Roberts, Timothy N Tiambeng, Jãán Andrews, Man-Di Wang, Jake A Melby

Res Sq· July 2023

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MASH Native: a unified solution for native top-down proteomics data processing.
Eli J Larson, Melissa R Pergande, Michelle E Moss, Kalina J Rossler, R Kent Wenger, Jake A Melby

Bioinformatics· June 2023

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Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics.
Emily A Chapman, David S Roberts, Timothy N Tiambeng, Jaan Andrews, Man-Di Wang, Jake A Melby

bioRxiv· June 2023

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High sensitivity top-down proteomics captures single muscle cell heterogeneity in large proteoforms.
Jake A Melby, Kyle A Brown, Zachery R Gregorich, David S Roberts, Emily A Chapman

Proc Natl Acad Sci U S A· May 2023

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Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs.
Kalina J Rossler, Willem J de Lange, Morgan W Mann, Timothy J Aballo, Jake A Melby

bioRxiv· May 2023

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Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics.
Holden T Rogers, David S Roberts, Eli J Larson, Jake A Melby, Kalina J Rossler

bioRxiv· April 2023

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Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-Down Proteomics.
Emily A Chapman, Timothy J Aballo, Jake A Melby, Tianhua Zhou, Scott J Price

J Proteome Res· March 2023

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MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing.
Eli J Larson, Melissa R Pergande, Michelle E Moss, Kalina J Rossler, R Kent Wenger, Jake A Melby

bioRxiv· January 2023

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ablation is associated with changes in the expression of titin-interacting and metabolic proteins.
Eli J Larson, Zachery R Gregorich, Yanghai Zhang, Brad H Li, Timothy J Aballo, Jake A Melby

Mol Omics· August 2022

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Size Exclusion Chromatography Strategies and MASH Explorer for Large Proteoform Characterization.
Timothy N Tiambeng, Zhijie Wu, Jake A Melby, Ying Ge

Methods Mol Biol· June 2022

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Ultrafast and Reproducible Proteomics from Small Amounts of Heart Tissue Enabled by Azo and timsTOF Pro.
Timothy J Aballo, David S Roberts, Jake A Melby, Kevin M Buck, Kyle A Brown

J Proteome Res· August 2021

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Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry.
David S Roberts, Morgan Mann, Jake A Melby, Eli J Larson, Yanlong Zhu

J Am Chem Soc· August 2021

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High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry.
Eli J Larson, David S Roberts, Jake A Melby, Kevin M Buck, Yanlong Zhu

Anal Chem· July 2021

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Novel Strategies to Address the Challenges in Top-Down Proteomics.
Jake A Melby, David S Roberts, Eli J Larson, Kyle A Brown, Elizabeth F Bayne

J Am Soc Mass Spectrom· June 2021

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Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry.
David S Roberts, Morgan W Mann, Jake A Melby, Eli J Larson, Yanlong Zhu

bioRxiv· March 2021

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Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues.
Jake A Melby, Willem J de Lange, Jianhua Zhang, David S Roberts, Stanford D Mitchell

J Proteome Res· February 2021

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Top-down proteomics: challenges, innovations, and applications in basic and clinical research.
Kyle A Brown, Jake A Melby, David S Roberts, Ying Ge

Expert Rev Proteomics· October 2020

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MASH Explorer: A Universal Software Environment for Top-Down Proteomics.
Zhijie Wu, David S Roberts, Jake A Melby, Kent Wenger, Molly Wetzel

J Proteome Res· September 2020

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Top-Down Proteomics Reveals Myofilament Proteoform Heterogeneity among Various Rat Skeletal Muscle Tissues.
Jake A Melby, Yutong Jin, Ziqing Lin, Trisha Tucholski, Zhijie Wu

J Proteome Res· January 2020

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