Publications by authors named "James A Huntington"

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Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa.
Fatma Işık Üstok, James A Huntington

J Thromb Haemost· November 2025

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A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex.
Fatma Işık Üstok, Alexandre Faille, James A Huntington

Blood· October 2025

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The rumen microbiota and metabolism of dairy cows are affected by the dietary rate of inclusion of extract.
Timothy J Snelling, Marykate Condren, James A Huntington, Helen E Warren, Jules Taylor-Pickard

Microbiol Spectr· August 2025

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The preclinical profile of SerpinPC: a potential new treatment for hemophilia.
James A Huntington, Jill Reckless, Stéphanie G I Polderdijk, Patrick Hextall, Trevor P Baglin

Blood Adv· May 2025

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Serious issues with cryo-EM structures of human prothrombinase.
James A Huntington, Alexandre Faille, Fatma Isik Ustok

Open Biol· January 2025

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Rapid and ordered cleavage of prothrombin by Hopsarin D in the absence of phospholipid membranes.
Fatma Işık Üstok, Ty E Adams, James A Huntington

J Thromb Haemost· November 2024

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Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma.
Sylwia Modrzycka, Sonia Kołt, Ty E Adams, Stanisław Potoczek, James A Huntington

J Med Chem· March 2023

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Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma.
Sylwia Modrzycka, Sonia Kołt, Stéphanie G I Polderdijk, Ty E Adams, Stanisław Potoczek, James A Huntington

Chem Sci· June 2022

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Mapping the prothrombin-binding site of pseutarin C by site-directed PEGylation.
Fatma Işık Üstok, James A Huntington

Blood· May 2022

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Z-α-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state.
Joseph E Chambers, Nikita Zubkov, Markéta Kubánková, Jonathon Nixon-Abell, Ioanna Mela, James A Huntington

Sci Adv· April 2022

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Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.
Jan Kotál, Stéphanie G I Polderdijk, Helena Langhansová, Monika Ederová, Larissa A Martins, James A Huntington

Int J Mol Sci· August 2021

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Characterization of the neutralizing anti-emicizumab antibody in a patient with hemophilia A and inhibitor.
Carla Valsecchi, Marco Gobbi, Marten Beeg, Ty Adams, Giancarlo Castaman, James A Huntington

J Thromb Haemost· March 2021

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Linkage analysis combined with whole-exome sequencing identifies a novel prothrombin () gene mutation in a Dutch Caucasian family with unexplained thrombosis.
René Mulder, Ton Lisman, Joost C M Meijers, James A Huntington, André B Mulder

Haematologica· July 2020

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Long term dietary supplementation with microalgae increases plasma docosahexaenoic acid in milk and plasma but does not affect plasma 13,14-dihydro-15-keto PGF concentration in dairy cows.
Bethan E Till, James A Huntington, Kirsty E Kliem, Jules Taylor-Pickard, Liam A Sinclair

J Dairy Res· February 2020

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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Katherine A Vousden, Tomas Lundqvist, Bojana Popovic, Brian Naiman, Alan M Carruthers, James A Huntington

Sci Rep· February 2019

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Identification of serpins specific for activated protein C using a lysate-based screening assay.
Stéphanie G I Polderdijk, James A Huntington

Sci Rep· June 2018

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The anaerobic digestion of pig carcase with or without sugar beet pulp, as a novel on-farm disposal method.
Marie E Kirby, Michael K Theodorou, Carole M Brizuela, James A Huntington, Jayne Powles

Waste Manag· May 2018

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Targeting activated protein C to treat hemophilia.
Stéphanie G I Polderdijk, Trevor P Baglin, James A Huntington

Curr Opin Hematol· September 2017

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SERPINC1 gene mutations in antithrombin deficiency.
René Mulder, F Nanne Croles, André B Mulder, James A Huntington, Karina Meijer

Br J Haematol· July 2017

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Whole-exome sequencing in evaluation of patients with venous thromboembolism.
Eun-Ju Lee, Daniel J Dykas, Andrew D Leavitt, Rodney M Camire, Eduard Ebberink, James A Huntington

Blood Adv· July 2017

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Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from , a causative agent of gum disease from the human oral microbiome.
Anja Pomowski, Isabel Usón, Zuzanna Nowakowska, Florian Veillard, Maryta N Sztukowska, James A Huntington

J Biol Chem· April 2017

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Design and characterization of an APC-specific serpin for the treatment of hemophilia.
Stéphanie G I Polderdijk, Ty E Adams, Lacramioara Ivanciu, Rodney M Camire, Trevor P Baglin, James A Huntington

Blood· January 2017

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Structural transitions during prothrombin activation: On the importance of fragment 2.
Ty E Adams, James A Huntington

Biochimie· March 2016

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Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.
Iñaki de Diego, Florian Veillard, Maryta N Sztukowska, Tibisay Guevara, Barbara Potempa, James A Huntington

J Biol Chem· November 2014

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The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization.
Manja A Behrens, Timothy J Sendall, Jan S Pedersen, Morten Kjeldgaard, James A Huntington

Biophys J· October 2014

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