Publications by authors named "James A Roper"

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Pharmacological Characterization of GB1908, a Selective Galectin-1 Carbohydrate Binding Domain Inhibitor for the Treatment of Cancer.
Kimberly D Herman, Ian Holyer, Duncan C Humphries, James A Roper, Kristoffer Peterson

Pharmacology· August 2025

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Inhibition of EphA2 by syndecan-4 in wounded skin regulates clustering of fibroblasts.
Rebecca Brooks, Xianhui Wei, Mang Leng Lei, Francisca Cisterna Cid, James A Roper

J Mol Cell Biol· June 2025

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Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver.
Alison C MacKinnon, Duncan C Humphries, Kimberley Herman, James A Roper, Ian Holyer

Eur J Pharmacol· December 2024

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Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer.
Kristoffer Peterson, Ulf J Nilsson, Lise Gravelle, Ian Holyer, Karl Jansson, James A Roper

J Med Chem· December 2024

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Core Modifications of GSK3335103 toward Orally Bioavailable αβ Inhibitors with Improved Synthetic Tractability.
Heather F Hryczanek, John Barrett, Tim N Barrett, Glenn A Burley, Rosa E Cookson, James A Roper

J Med Chem· November 2024

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Galectin-1 Induces the Production of Immune-Suppressive Cytokines in Human and Mouse T Cells.
Kimberly D Herman, Ian Holyer, Duncan C Humphries, Anna Adamska, James A Roper

Int J Mol Sci· November 2024

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Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.
Fredrik R Zetterberg, Kristoffer Peterson, Ulf J Nilsson, Kajsa Andréasson Dahlgren, Carl Diehl, James A Roper

J Med Chem· June 2024

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Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance.
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper

Int J Mol Sci· June 2024

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A Quantitative Human Red Blood Cell Agglutination Assay for Characterisation of Galectin Inhibitors.
Rhianna Gasson, James A Roper, Robert J Slack

Int J Mol Sci· June 2024

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Discovery of Selective and Orally Available Galectin-1 Inhibitors.
Fredrik R Zetterberg, Carl Diehl, Maria Håkansson, Barbro Kahl-Knutson, Hakon Leffler, James A Roper

J Med Chem· December 2023

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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1.
Joseph Mabbitt, Ian D Holyer, James A Roper, Ulf J Nilsson, Fredrik R Zetterberg

Front Immunol· September 2023

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Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance.
Henry Kim, Nathalie Weidner, Céline Ronin, Emmanuel Klein, James A Roper

SLAS Discov· July 2023

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Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
Fredrik R Zetterberg, Alison MacKinnon, Thomas Brimert, Lise Gravelle, Richard E Johnsson, James A Roper

J Med Chem· October 2022

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Integrins as a drug target in liver fibrosis.
Syedia R Rahman, James A Roper, Jane I Grove, Guruprasad P Aithal, K Tao Pun

Liver Int· March 2022

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Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease.
Alex L Wilkinson, Alison E John, John W Barrett, E Gower, Valerie S Morrison, James A Roper

Eur J Pharmacol· December 2021

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Downregulation of the v6 Integrin via RGD Engagement Is Affinity and Time Dependent.
James A Roper, Alex L Wilkinson, Elaine Gower, Robert J Slack

J Pharmacol Exp Ther· February 2021

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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.
Alison E John, Rebecca H Graves, K Tao Pun, Giovanni Vitulli, Ellen J Forty, James A Roper

Nat Commun· September 2020

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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αβ Integrin Inhibitor-(3)-3-(3-(3,5-Dimethyl-1-pyrazol-1-yl)phenyl)-4-((1 and 1,3)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
Tim N Barrett, Jonathan A Taylor, Daniel Barker, Panayiotis A Procopiou, James D F Thompson, James A Roper

J Med Chem· August 2019

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Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing.
Michele E Barbour, Sarah E Maddocks, Helena J Grady, James A Roper, Mark D Bass

Nanomedicine (Lond)· August 2016

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Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1.
James A Roper, Rosalind C Williamson, Blandine Bally, Christopher A M Cowell, Rebecca Brooks

J Invest Dermatol· November 2015

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Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking.
Rosalind C Williamson, Christopher A M Cowell, Thomas Reville, James A Roper, Thomas C S Rendall

J Biol Chem· June 2015

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Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Rosalind C Williamson, Christopher A M Cowell, Christina L Hammond, Dylan J M Bergen, James A Roper

J Cell Sci· October 2014

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Syndecan and integrin interactomes: large complexes in small spaces.
James A Roper, Rosalind C Williamson, Mark D Bass

Curr Opin Struct Biol· October 2012

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G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis.
Georgina G J Hazell, Charles C Hindmarch, George R Pope, James A Roper, Stafford L Lightman

Front Neuroendocrinol· January 2012

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Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues.
Georgina G J Hazell, Song T Yao, James A Roper, Eric R Prossnitz, Anne-Marie O'Carroll

J Endocrinol· August 2009

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