Publications by authors named "James Bown"

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The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution.
Firat Ozcelik, Mehmet Sait Dundar, A Baki Yildirim, Gary Henehan, Oscar Vicente, James Bown

Funct Integr Genomics· August 2024

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Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis.
Charlotte M Jones-Todd, Peter Caie, Janine B Illian, Ben C Stevenson, Anne Savage, James L Bown

Stat Med· April 2019

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NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib.
Ibrahim H Kankia, Hilal S Khalil, Simon P Langdon, Peter R Moult, James L Bown

Oxid Med Cell Longev· August 2018

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A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT.
James L Bown, Mark Shovman, Paul Robertson, Andrei Boiko, Alexey Goltsov

Oncotarget· May 2017

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Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002.
Alexey Goltsov, Ghassan Tashkandi, Simon P Langdon, David J Harrison, James L Bown

Eur J Pharm Sci· January 2017

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A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells.
Hilal S Khalil, Simon P Langdon, Alexey Goltsov, Tero Soininen, David J Harrison, James Bown

Oncotarget· November 2016

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NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies.
Hilal S Khalil, Simon P Langdon, Ibrahim H Kankia, James Bown, Yusuf Y Deeni

Oxid Med Cell Longev· October 2016

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Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells.
Hilal S Khalil, Alexey Goltsov, Simon P Langdon, David J Harrison, James Bown

J Biotechnol· May 2015

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Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy.
Alexey Goltsov, Yusuf Deeni, Hilal S Khalil, Tero Soininen, Stylianos Kyriakidis, James Bown

Cells· June 2014

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Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations.
Alexey Goltsov, Simon P Langdon, Gregory Goltsov, David J Harrison, James Bown

Front Oncol· February 2014

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Characterising the tumour morphological response to therapeutic intervention: an ex vivo model.
Anne Savage, Elad Katz, Alistair Eberst, Ruth E Falconer, Alasdair Houston, James Bown

Dis Model Mech· January 2013

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Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.
Huizhong Hu, Alexey Goltsov, James L Bown, Andrew H Sims, Simon P Langdon

Cell Signal· January 2013

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Engineering simulations for cancer systems biology.
James Bown, Paul S Andrews, Yusuf Deeni, Alexey Goltsov, Michael Idowu

Curr Drug Targets· November 2012

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Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition.
Alexey Goltsov, Dana Faratian, Simon P Langdon, Peter Mullen, David J Harrison, James Bown

Cell Signal· February 2012

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Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition.
Alexey Goltsov, Dana Faratian, Simon P Langdon, James Bown, Igor Goryanin

Cell Signal· February 2011

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Cancer systems biology.
Dana Faratian, James L Bown, V Anne Smith, Simon P Langdon, David J Harrison

Methods Mol Biol· December 2010

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Modelling fungal colonies and communities: challenges and opportunities.
Ruth E Falconer, James L Bown, Eilidh McAdam, Paco Perez-Reche, Adam T Sampson

IMA Fungus· December 2010

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A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells.
Robert G Clyde, Ashley L Craig, Lucas de Breed, James L Bown, Leslie Forrester

J R Soc Interface· December 2009

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Modelling interactions in fungi.
Ruth E Falconer, James L Bown, Nia A White, John W Crawford

J R Soc Interface· June 2008

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The role of modelling in identifying drug targets for diseases of the cell cycle.
Robert G Clyde, James L Bown, Ted R Hupp, Nikolai Zhelev, John W Crawford

J R Soc Interface· October 2006

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Biomass recycling and the origin of phenotype in fungal mycelia.
Ruth E Falconer, James L Bown, Nia A White, John W Crawford

Proc Biol Sci· August 2005

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The effects of fungal inoculum arrangement (scale and context) on emergent community development in an agar model system.
Craig J Sturrock, Karl Ritz, William B Samson, James L Bown, Harry J Staines

FEMS Microbiol Ecol· January 2002

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