Publications by authors named "James Clair"

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The Role of Natural Product Chemistry in Drug Discovery: Two Decades of Progress and Perspectives.
Mark S Butler, James J La Clair

J Nat Prod· December 2025

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Role of Human Mitochondrial Ketosynthase in Long-Chain Fatty Acid Biosynthesis.
Yixing Suo, Ziran Jiang, Graham W Heberlig, Elsabella Y Wang, Banumathi Sankaran, James J La Clair

J Am Chem Soc· September 2025

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Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase.
Ziran Jiang, Graham W Heberlig, Jeffrey A Chen, Jennifer Huynh, James J La Clair

Nat Commun· August 2025

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Democratized Discovery of Microsclerodermin F as an Immunophilin Ligand.
Manfred Auer, Malcolm D Walkinshaw, Jacqueline Dornan, Nhan T Pham, Xinru Xue, James J La Clair

Mar Drugs· August 2025

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Engineering regiospecific methylation of the pladienolides.
Emily R Smith, Dua H Al-Smadi, Yitao Dai, Manead Khin, Joanna E Burdette, James J La Clair

RSC Chem Biol· July 2025

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Elucidating the Iterative Elongation Mechanism in a Type III Polyketide Synthase.
Rebecca N Re, James J La Clair, Joseph P Noel, Michael D Burkart

J Am Chem Soc· May 2025

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Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis.
Graham W Heberlig, James J La Clair, Michael D Burkart

Nature· February 2025

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Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism.
Matthew G Miyada, Yuran Choi, Kyle Rich, James J La Clair, Michael D Burkart

Chem Sci· December 2024

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Repositioning Brusatol as a Transmission Blocker of Malaria Parasites.
Amelia Cox, Neelima Krishnankutty, Steven Shave, Virginia M Howick, Manfred Auer, James J La Clair

ACS Infect Dis· October 2024

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Quantitative Characterization of Chain-Flipping of Acyl Carrier Protein of Using Chemical Exchange NMR.
Brianna N Kalaj, James J La Clair, Yang Shen, Charles D Schwieters, Lalit Deshmukh

J Am Chem Soc· July 2024

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Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe.
Matthew G Miyada, Yuran Choi, Ramunas Stepanauskas, Tanja Woyke, James J La Clair

ACS Chem Biol· July 2024

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Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition.
Ziran Jiang, Jeffrey A Chen, Osama G Mohamed, Jennifer Huynh, Aochiu Chen, James J La Clair

J Am Chem Soc· July 2024

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Elevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog.
Neda Kortam, Wenying Liang, Claire Shiple, Suiyuan Huang, Rosemary Gedert, James St Clair

Arthritis Res Ther· July 2024

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Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase.
Rodrigo Dos A Miguel, Amanda S Hirata, Giovanna C Salata, Alexsandra C Apolinário, Vinicius M Barroso, James J La Clair

Eur J Pharm Sci· January 2024

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Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes.
Aochiu Chen, Rebecca N Re, Tony D Davis, Kelley Tran, Yuta W Moriuchi, James J La Clair

J Am Chem Soc· January 2024

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Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein.
Yixing Suo, Aochiu Chen, James J La Clair, Michael D Burkart

Biochemistry· December 2023

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Masked cerulenin enables a dual-site selective protein crosslink.
Ziran Jiang, Aochiu Chen, Jeffrey Chen, Arman Sekhon, Gordon V Louie, James J La Clair

Chem Sci· October 2023

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Interface Engineering of Carrier-Protein-Dependent Metabolic Pathways.
Terra Sztain, Joshua C Corpuz, Thomas G Bartholow, Javier O Sanlley Hernandez, Ziran Jiang, James J La Clair

ACS Chem Biol· September 2023

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Nanoscaled Discovery of a Shunt Rifamycin from Using a Three-Color GFP-Tagged Macrophage Infection Assay.
Nhan T Pham, Joana Alves, Fiona A Sargison, Reiko Cullum, Jan Wildenhain, James J La Clair

ACS Infect Dis· August 2023

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Synthase-selected sorting approach identifies a beta-lactone synthase in a nudibranch symbiotic bacterium.
Mária Džunková, James J La Clair, Tomáš Tyml, Devin Doud, Frederik Schulz

Microbiome· June 2023

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Stereochemical Control of Splice Modulation in FD-895 Analogues.
Warren C Chan, Kelsey A Trieger, James J La Clair, Catriona H M Jamieson, Michael D Burkart

J Med Chem· May 2023

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Reversal of malignant ADAR1 splice isoform switching with Rebecsinib.
Leslie A Crews, Wenxue Ma, Luisa Ladel, Jessica Pham, Larisa Balaian, James J La Clair

Cell Stem Cell· March 2023

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Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells.
Inge van der Werf, Phoebe K Mondala, S Kathleen Steel, Larisa Balaian, Luisa Ladel, James J La Clair

Cell Rep Med· March 2023

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A Survey of Didemnin Depsipeptide Production in .
Robert J Stankey, Don Johnson, Brendan M Duggan, David A Mead, James J La Clair

Mar Drugs· January 2023

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Medicinal chemical optimization of fluorescent pyrrole-based COX-2 probes.
Sachin B Wagh, Vladimir Maslivetc, James J La Clair, Alexander Kornienko

Tetrahedron· September 2022

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