Publications by authors named "James Cregg"

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A Brief History of the Pichia pastoris Expression System.
James M Cregg, Thomas G Chappel, Kurt R Gehlsen, Shaun A Kirkpatrick, Knut Madden

Methods Mol Biol· October 2025

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Classical Genetics of Pichia pastoris.
Ilya Tolstorukov, Thomas G Chappell, James M Cregg

Methods Mol Biol· October 2025

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Correction: Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J Maldonato, Yingyun Wang, Matthew Holderfield, James Cregg

Cancer Discov· October 2025

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Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers.
James Cregg, Kristof Pota, Aidan C A Tomlinson, Jason Yano, Abby Marquez

J Med Chem· March 2025

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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
James Cregg, Anne V Edwards, Stephanie Chang, Bianca J Lee, John E Knox

J Med Chem· March 2025

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Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J Maldonato, Yingyun Wang, Matthew Holderfield, James Cregg

Cancer Discov· June 2024

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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
G Leslie Burnett, Yu C Yang, James B Aggen, Jennifer Pitzen, Micah K Gliedt, James Cregg

J Med Chem· January 2023

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Ruthenium-catalysed multicomponent synthesis of the 1,3-dienyl-6-oxy polyketide motif.
Barry M Trost, James J Cregg, Christoph Hohn, Wen-Ju Bai, Guoting Zhang

Nat Chem· July 2020

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Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend ' Lifespan.
Peichuan Zhang, Yuying Zhai, James Cregg, Kenny Kean-Hooi Ang, Michelle Arkin

G3 (Bethesda)· February 2020

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Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA.
Nathan Wan, David Weinberg, Tzu-Yu Liu, Katherine Niehaus, Eric A Ariazi, James Cregg

BMC Cancer· August 2019

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Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted 1 H-Indoles and Tryptophan Derivatives with Vinylcyclopropanes.
Barry M Trost, Wen-Ju Bai, Christoph Hohn, Yu Bai, James J Cregg

J Am Chem Soc· May 2018

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A New Yeast Peroxin, Pex36, a Functional Homolog of Mammalian PEX16, Functions in the ER-to-Peroxisome Traffic of Peroxisomal Membrane Proteins.
Jean-Claude Farré, Krypton Carolino, Oleh V Stasyk, Olena G Stasyk, Zlatan Hodzic, James Cregg

J Mol Biol· November 2017

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Isomerization of N-Allyl Amides To Form Geometrically Defined Di-, Tri-, and Tetrasubstituted Enamides.
Barry M Trost, James J Cregg, Nicolas Quach

J Am Chem Soc· April 2017

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Ru-catalyzed sequence for the synthesis of cyclic amido-ethers.
Barry M Trost, Ehesan U Sharif, James J Cregg

Chem Sci· January 2017

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Refined Pichia pastoris reference genome sequence.
Lukas Sturmberger, Thomas Chappell, Martina Geier, Florian Krainer, Kasey J Day, James Cregg

J Biotechnol· October 2016

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Ruthenium-catalyzed alkene-alkyne coupling of disubstituted olefins: application to the stereoselective synthesis of trisubstituted enecarbamates.
Barry M Trost, James J Cregg

J Am Chem Soc· January 2015

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Towards improved membrane protein production in Pichia pastoris: general and specific transcriptional response to membrane protein overexpression.
Thomas Vogl, Gerhard G Thallinger, Guenther Zellnig, David Drew, James M Cregg

N Biotechnol· December 2014

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Guidelines for the use and interpretation of assays for monitoring autophagy.
Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, James M Cregg

Autophagy· April 2012

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Atg35, a micropexophagy-specific protein that regulates micropexophagic apparatus formation in Pichia pastoris.
Volodymyr Y Nazarko, Taras Y Nazarko, Jean-Claude Farré, Oleh V Stasyk, Dirk Warnecke, James M Cregg

Autophagy· April 2011

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Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris.
Philipp Ternes, Tobias Wobbe, Marnie Schwarz, Sandra Albrecht, Kirstin Feussner, James M Cregg

J Biol Chem· April 2011

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Sustainability metrics: life cycle assessment and green design in polymers.
Michaelangelo D Tabone, James J Cregg, Eric J Beckman, Amy E Landis

Environ Sci Technol· November 2010

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Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy.
Ping Zhang, Wenwen Zhang, Xiangshan Zhou, Peng Bai, James M Cregg

Appl Environ Microbiol· September 2010

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Expression in the yeast Pichia pastoris.
James M Cregg, Ilya Tolstorukov, Anasua Kusari, Jay Sunga, Knut Madden

Methods Enzymol· January 2010

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Identification of phosphatidylserine decarboxylases 1 and 2 from Pichia pastoris.
Tamara Wriessnegger, Anthony Jay Sunga, James M Cregg, Guenther Daum

FEMS Yeast Res· September 2009

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Posttransformational vector amplification in the yeast Pichia pastoris.
Anthony Jay Sunga, Ilya Tolstorukov, James M Cregg

FEMS Yeast Res· September 2008

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