Publications by authors named "James Dear"

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Adverse drug reactions, particularly liver disorders, drive interruptions in anti-tuberculosis treatment: A retrospective cohort study.
Eleanor G Dixon, Evita Biraua, Edvards Brencsēns, Vitālijs Pašuks, Vija Riekstina, James W Dear

Br J Clin Pharmacol· December 2025

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Scottish and Newcastle Antiemetic Protocol (SNAP) 12-hour acetylcysteine regimen for paracetamol overdose reduces anaphylactoid reactions without compromising hepatic protection in all age groups: a secondary analysis.
Christopher Humphries, Janice Pettie, Bridget Agboola, Thomas M Caparrotta, Robert W Hunter, James Dear

Emerg Med J· December 2025

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Retraction Notice to: "CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure" Gastroenterology 2015;149:1896-1909.e14.
Benjamin M Stutchfield, Daniel J Antoine, Alison C Mackinnon, Deborah J Gow, Calum C Bain, James W Dear

Gastroenterology· December 2025

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Clinical characterisation of the novel benzodiazepine bromazolam-data from the ASSIST (A Surveillance Study of Illicit Substance Toxicity) study.
Lisa C Dunlop, Vicki Craik, Nicole Jarvie, Simon Hudson, Matthew Walters, James W Dear

Clin Toxicol (Phila)· November 2025

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Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA-122 in hospital clinical laboratories.
Samar Alzeer, Antonio Marin-Romero, Bárbara López-Longarela, Juan J Guardia-Monteagudo, F Javier Lopez-Delgado, James W Dear

Br J Clin Pharmacol· November 2025

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Isotocyanozene: detection of the 5-cyano analog of isotonitazene in human biological samples.
Ryan D McHenry, Lisa C Dunlop, Simon Hudson, Matthew Walters, James W Dear

Clin Toxicol (Phila)· September 2025

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SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse.
Robert W Hunter, Jialin Sun, Trecia Palmer, Alicja Czopek, Josselin Nespoux, James W Dear

Nat Commun· August 2025

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Nitazene detections and clinical characteristics: data from a prospective observational study in a Glasgow emergency department.
Rufus Turner, Lisa Christine Dunlop, David John Lowe, Fraser Norman, Vicki Craik, James Dear

Emerg Med J· July 2025

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A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay.
Sian Sloan-Dennison, Kathleen M Scullion, Benjamin Clark, Paul Fineran, Joanne Mair, James W Dear

Nat Commun· July 2025

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Roadblocks of Urinary EV Biomarkers: Moving Toward the Clinic.
Marvin Droste, Maija Puhka, Martin E van Royen, Monica S Y Ng, Charles Blijdorp, James W Dear

J Extracell Vesicles· July 2025

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Antidotes in the management of poisoned patients: What have we gained over the last decade?
David Michael Wood, James William Dear, Ruben Thanacoody, David Nelson Juurlink, Angela Lin Chiew

Br J Clin Pharmacol· March 2025

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BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity.
Patricia Marañón, Stephania C Isaza, Esther Rey, Patricia Rada, Yaiza García-García, James W Dear

Arch Toxicol· March 2025

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HiSNAP trial-a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose in the UK: study protocol.
Christopher Humphries, Ellise Clarke, Michael Eddleston, Marianne Gillings, Sian Irvine, James W Dear

BMJ Open· March 2025

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The emerging role of alternatively activated macrophages to treat acute liver injury.
Chris Humphries, Melisande L Addison, James W Dear, Stuart J Forbes

Arch Toxicol· January 2025

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Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse.
Maria Elena Candela, Melisande Addison, Rhona Aird, Tak-Yung Man, Jennifer A Cartwright, James W Dear

NPJ Regen Med· January 2025

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Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK.
Christopher Humphries, Melisande Addison, Guruprasad Aithal, Julia Boyd, Lesley Briody, James W Dear

BMJ Open· December 2024

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Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).
Kathleen M Scullion, Iain M MacIntyre, Sian Sloan-Dennison, Benjamin Clark, Paul Fineran, James W Dear

Toxicol Sci· May 2024

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Evaluation of capillary miR-122 as a prognostic biomarker of paracetamol-induced liver toxicity.
Marco Cirronis, Sarah Schneemann, Janice Pettie, Guido Mannaioni, James W Dear

Mol Biol Rep· April 2024

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Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis.
Susan K Armstrong, Robert W Hunter, Wilna Oosthyuzen, Maciej Parys, Adam G Gow, James W Dear

J Vet Intern Med· March 2024

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In severe alcohol-related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using IL-8 and micro-RNAs.
Luke D Tyson, Stephen Atkinson, Robert W Hunter, Michael Allison, Andrew Austin, James W Dear

Aliment Pharmacol Ther· December 2023

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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment.
Tariq E Farrah, Dan Pugh, Fiona A Chapman, Emily Godden, Craig Balmforth, James W Dear

Nat Commun· December 2023

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Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973-2023 with particular focus on contributions published from Edinburgh and Denver.
D Nicholas Bateman, Richard C Dart, James W Dear, Laurie F Prescott, Barry H Rumack

Clin Toxicol (Phila)· December 2023

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Paracetamol use in adults.
Thomas M Caparrotta, Emma Carduff, James W Dear

BMJ· November 2023

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Duration of consultant experience and patient outcome following acute medical unit admission: an observational cohort study.
Marcus J Lyall, James Dear, Johanne Simpson, Nazir Lone

Clin Med (Lond)· September 2023

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Novel biomarkers for drug-induced liver injury.
Christopher Humphries, James W Dear

Clin Toxicol (Phila)· August 2023

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