Publications by authors named "James Firman"

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Challenges and opportunities of read-across for the tumor promotion effects of microcystins.
Cynthia B Pestana, Daniela Morais Leme, Enzo Zini Moreira Silva, Sahra Kiessig, James W Firman

Regul Toxicol Pharmacol· December 2025

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Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR).
Samuel J Belfield, Homa Basiri, Chavan Swapnil, Georgios Chrysochoou, Steven J Enoch, James W Firman

ALTEX· October 2025

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The Findable, Accessible, Interoperable, Reusable (FAIR) Lite Principles to ensure utility of computational toxicology models.
Mark T D Cronin, Homa Basiri, Samuel J Belfield, Swapnil Chavan, Georgios Chrysochoou, James W Firman

ALTEX· September 2025

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Analysis of implicit and explicit uncertainties in QSAR prediction of chemical toxicity: A case study of neurotoxicity.
Jerry Achar, James W Firman, Chantelle Tran, Daniella Kim, Mark T D Cronin

Regul Toxicol Pharmacol· December 2024

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Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme.
James W Firman, Alan Boobis, Heli M Hollnagel, Stefan Kaiser, David P Lovell

Food Chem Toxicol· December 2024

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A framework for categorizing sources of uncertainty in in silico toxicology methods: Considerations for chemical toxicity predictions.
Jerry Achar, James W Firman, Mark T D Cronin, Gunilla Öberg

Regul Toxicol Pharmacol· December 2024

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The evaluation of skin sensitization potential of the UVCB substance diisopentyl phthalate by in silico and in vitro methods.
Isisdoris Rodrigues de Souza, Martina Iulini, Valentina Galbiati, Ana Carolina Rodrigues, Daniela Fiori Gradia, James W Firman

Arch Toxicol· July 2024

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A problem formulation framework for the application of in silico toxicology methods in chemical risk assessment.
Jerry Achar, Mark T D Cronin, James W Firman, Gunilla Öberg

Arch Toxicol· June 2024

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Update of the Cancer Potency Database (CPDB) to enable derivations of Thresholds of Toxicological Concern (TTC) for cancer potency.
Chihae Yang, James F Rathman, J Vinicius Ribeiro, Monika Batke, Sylvia E Escher, James W Firman

Food Chem Toxicol· December 2023

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Making in silico predictive models for toxicology FAIR.
Mark T D Cronin, Samuel J Belfield, Katharine A Briggs, Steven J Enoch, James W Firman

Regul Toxicol Pharmacol· May 2023

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Guidance for good practice in the application of machine learning in development of toxicological quantitative structure-activity relationships (QSARs).
Samuel J Belfield, Mark T D Cronin, Steven J Enoch, James W Firman

PLoS One· May 2023

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Construction of an In Silico Structural Profiling Tool Facilitating Mechanistically Grounded Classification of Aquatic Toxicants.
James W Firman, David J Ebbrell, Franklin J Bauer, Maria Sapounidou, Geoff Hodges

Environ Sci Technol· December 2022

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A scheme to evaluate structural alerts to predict toxicity - Assessing confidence by characterising uncertainties.
Mark T D Cronin, Franklin J Bauer, Mark Bonnell, Bruno Campos, David J Ebbrell, James W Firman

Regul Toxicol Pharmacol· November 2022

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The use of Bayesian methodology in the development and validation of a tiered assessment approach towards prediction of rat acute oral toxicity.
James W Firman, Mark T D Cronin, Philip H Rowe, Elizaveta Semenova, John E Doe

Arch Toxicol· March 2022

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A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage.
Courtney V Thompson, James W Firman, Michael R Goldsmith, Christopher M Grulke, Yu-Mei Tan

Altern Lab Anim· September 2021

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New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
Dagmar Bury, Camilla Alexander-White, Harvey J Clewell, Mark Cronin, Bertrand Desprez, James Firman

Regul Toxicol Pharmacol· July 2021

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Determination of "fitness-for-purpose" of quantitative structure-activity relationship (QSAR) models to predict (eco-)toxicological endpoints for regulatory use.
Samuel J Belfield, Steven J Enoch, James W Firman, Judith C Madden, Terry W Schultz

Regul Toxicol Pharmacol· July 2021

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Derivation, characterisation and analysis of an adverse outcome pathway network for human hepatotoxicity.
Emma Arnesdotter, Nicoleta Spinu, James Firman, David Ebbrell, Mark T D Cronin

Toxicology· July 2021

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Incorporating lines of evidence from New Approach Methodologies (NAMs) to reduce uncertainties in a category based read-across: A case study for repeated dose toxicity.
Cynthia B Pestana, James W Firman, Mark T D Cronin

Regul Toxicol Pharmacol· March 2021

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Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety.
James W Firman, Ans Punt, Mark T D Cronin, Alan R Boobis, Martin F Wilks

Chem Res Toxicol· February 2021

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A Robust, Mechanistically Based Structural Profiler for Hepatic Cholestasis.
James W Firman, Cynthia B Pestana, James F Rathman, Mathieu Vinken, Chihae Yang

Chem Res Toxicol· February 2021

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Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species.
Maria Sapounidou, David J Ebbrell, Mark A Bonnell, Bruno Campos, James W Firman

Environ Sci Technol· February 2021

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In Silico Identification of Chemicals Capable of Binding to the Ecdysone Receptor.
Claire L Mellor, Knut Erik Tollefsen, Carlie LaLone, Mark T D Cronin, James W Firman

Environ Toxicol Chem· July 2020

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Potential of ToxCast Data in the Safety Assessment of Food Chemicals.
Ans Punt, James Firman, Alan Boobis, Mark Cronin, John Paul Gosling

Toxicol Sci· April 2020

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Toxicology Data Resources to Support Read-Across and (Q)SAR.
Gopal Pawar, Judith C Madden, David Ebbrell, James W Firman, Mark T D Cronin

Front Pharmacol· June 2019

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