Publications by authors named "James Hsieh"

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AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma.
Danil Stupichev, Natalia Miheecheva, Ekaterina Postovalova, Yang Lyu, Akshaya Ramachandran, James J Hsieh

Cell Rep Med· August 2025

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Lenvatinib plus Pembrolizumab Following Immune Checkpoint Inhibitor Treatment in Patients with Metastatic Clear Cell Renal Cell Carcinoma: Results from Study 111/KEYNOTE-146.
Chung-Han Lee, Amishi Yogesh Shah, Arpit Rao, Matthew H Taylor, Christopher Di Simone, James J Hsieh

Eur Urol· November 2024

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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, James J Hsieh

Cell Rep· April 2024

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Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma.
Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, James Hsieh

Cancer Res· December 2023

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Author Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
Yige Wu, Nadezhda V Terekhanova, Wagma Caravan, Nataly Naser Al Deen, Preet Lal, James J Hsieh

Nat Commun· May 2023

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SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis.
Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, James J Hsieh

JCI Insight· February 2023

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Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Briana G Nixon, Fengshen Kuo, LiangLiang Ji, Ming Liu, Kristelle Capistrano, James J Hsieh

Immunity· November 2022

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Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial.
Chung-Han Lee, Robert Motzer, Hamid Emamekhoo, Marc Matrana, Ivor Percent, James J Hsieh

Clin Cancer Res· August 2022

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Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes.
Aleksandr Zaitsev, Maksim Chelushkin, Daniiar Dyikanov, Ilya Cheremushkin, Boris Shpak, James J Hsieh

Cancer Cell· August 2022

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Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity.
Natalia Miheecheva, Ekaterina Postovalova, Yang Lyu, Akshaya Ramachandran, Alexander Bagaev, James J Hsieh

Cell Rep· August 2022

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SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes.
Yuchen Xie, Merve Sahin, Sonali Sinha, Yufeng Wang, Amrita M Nargund, James J Hsieh

Nat Cancer· February 2022

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Diagnostic Utility of RNA-Seq for Evaluation of PD-L1 Expression in Clear Cell Renal Cell Carcinoma.
Maria Sorokina, Danil Stupichev, Yang Lyu, Akshaya Ramachandran, Natalia Miheecheva, James J Hsieh

Clin Genitourin Cancer· December 2021

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis.
Kosuke Tanaka, Helena A Yu, Shaoyuan Yang, Song Han, S Duygu Selcuklu, James J Hsieh

Cancer Cell· September 2021

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Structural insights into the function of the catalytically active human Taspase1.
Nirupa Nagaratnam, Silvia L Delker, Rebecca Jernigan, Thomas E Edwards, Janey Snider, James J Hsieh

Structure· August 2021

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A Single-arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients with Advanced Non-Clear Cell Renal Cell Carcinoma.
Thomas E Hutson, M Dror Michaelson, Timothy M Kuzel, Neeraj Agarwal, Ana M Molina, James J Hsieh

Eur Urol· August 2021

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Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.
Hidetaka Niizuma, Adam C Searleman, Shugaku Takeda, Scott A Armstrong, Christopher Y Park, James J Hsieh

JCI Insight· August 2021

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Lenvatinib plus pembrolizumab in patients with either treatment-naive or previously treated metastatic renal cell carcinoma (Study 111/KEYNOTE-146): a phase 1b/2 study.
Chung-Han Lee, Amishi Yogesh Shah, Drew Rasco, Arpit Rao, Matthew H Taylor, James J Hsieh

Lancet Oncol· July 2021

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Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer.
Russell K Pachynski, Eric H Kim, Natalia Miheecheva, Nikita Kotlov, Akshaya Ramachandran, James J Hsieh

Clin Cancer Res· June 2021

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Resource-efficient pooled sequencing expands translational impact in solid tumors.
Renzo G DiNatale, Roy Mano, Vladimir Makarov, Nicole Rusk, Esther Drill, James J Hsieh

Kidney Cancer J· June 2021

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The 2021 Variant Histology Issue.
James J Hsieh

Clin Genitourin Cancer· April 2021

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Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
Toni K Choueiri, Thomas Powles, Mauricio Burotto, Bernard Escudier, Maria T Bourlon, James J Hsieh

N Engl J Med· March 2021

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The 2021 COVID-19 Artificial Intelligence Issue.
James J Hsieh

Clin Genitourin Cancer· February 2021

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The 2020 nccRCC Immunotherapy Issue.
James J Hsieh

Clin Genitourin Cancer· December 2020

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The Pan-Omics Landscape of Renal Cell Carcinoma and Its Implication on Future Clinical Practice.
Jennifer J Huang, James J Hsieh

Kidney Cancer· September 2020

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