Publications by authors named "James Klinger"

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The Liver is an Inflammatory Mediator of Pulmonary Arterial Hypertension.
Navneet Singh, Jordan Lawson, Ashok Ragavendran, Somanshu Banerjee, Andy Hon, James R Klinger

bioRxiv· December 2025

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Individualized Interactomes from Pulmonary Arterial Hypertension Cell Biopsies Predict Therapeutic Response.
Rui-Sheng Wang, Navneet Singh, Henri Wathieu, Grayson Baird, Katherine Cox-Flaherty, James R Klinger

medRxiv· November 2025

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American Lung Association Pulmonary Hypertension Roundtable: Executive Summary.
Nicholas Andreas Kolaitis, Sandeep Sahay, Erika Berman Rosenzweig, Deborah Brown, Anna Hemnes, James R Klinger

Pulm Circ· October 2025

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Effects of Dehydroepiandrosterone in Pulmonary Hypertension (EDIPHY): A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.
Rachel Sanders, Thomas Walsh, Grayson L Baird, Michael K Atalay, Saurabh Agarwal, James R Klinger

medRxiv· August 2025

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Predicting Response to Switching From Phosphodiesterase Type 5 Inhibitor to Riociguat in Patients With Pulmonary Arterial Hypertension: Biomarker and Responder Analysis of the RESPITE and REPLACE Studies.
James R Klinger, Hikmet Al-Hiti, Sung-A Chang, Hyuk J Chang, Hossein-Ardeschir Ghofrani

Pulm Circ· July 2025

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Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension.
Navneet Singh, Carsten Eickhoff, Augusto Garcia-Agundez, Paul Bertone, Sunita S Paudel, James R Klinger

Sci Rep· December 2023

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Burden of pulmonary hypertension due to chronic obstructive pulmonary disease: Analysis of exacerbations and healthcare resource utilization in the United States.
James R Klinger, Benjamin Wu, Kellie Morland, Peter Classi, Ryan Fiano

Respir Med· November 2023

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Emerging pharmacotherapies for the treatment of pulmonary arterial hypertension.
Roger Auth, James R Klinger

Expert Opin Investig Drugs· November 2023

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Light at the ENDothelium-role of Sox17 and Runx1 in endothelial dysfunction and pulmonary arterial hypertension.
Robert Simmons Beck, Olin D Liang, James R Klinger

Front Cardiovasc Med· November 2023

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Deletion of the gene increases severity of acute lung injury in obese mice.
Brianna D Guarino, Christopher D Dado, Ashok Kumar, Julie Braza, Elizabeth O Harrington, James R Klinger

Pulm Circ· July 2023

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Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, James R Klinger

Circulation· May 2023

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Impact of the COVID-19 pandemic on chronic disease management and patient reported outcomes in patients with pulmonary hypertension: The Pulmonary Hypertension Association Registry.
Megan Mayer, David B Badesch, Kelly H Nielsen, Steven Kawut, Todd Bull, James Klinger

Pulm Circ· April 2023

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Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension.
Euy-Myoung Jeong, Mandy Pereira, Eui-Young So, Keith Q Wu, Michael Del Tatto, James R Klinger

Cardiovasc Res· December 2022

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Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.
Elizabeth O Harrington, Ashok Kumar, Verida Leandre, Zachary S Wilson, Brianna Guarino, James R Klinger

Am J Physiol Lung Cell Mol Physiol· October 2022

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Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry.
Hilary M DuBrock, Charles D Burger, Sonja D Bartolome, Jeremy P Feldman, David D Ivy, James R Klinger

Pulm Circ· October 2022

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Hispanic Ethnicity and Social Determinants of Health in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry.
Roberto J Bernardo, Di Lu, Ramon L Ramirez, Haley Hedlin, Steven M Kawut, James R Klinger

Ann Am Thorac Soc· September 2022

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Reply to Helgeson : Remote 6-minute-Walk Testing in Patients with Pulmonary Hypertension: Further Validation Needed?
Tess LaPatra, Grayson L Baird, Randi Goodman, Diane Pinder, Maeve Gaffney, James R Klinger

Am J Respir Crit Care Med· September 2022

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Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension.
Xiuna Sun, Erika Nakajima, Carmelissa Norbrun, Parand Sorkhdini, Alina Xiaoyu Yang, James R Klinger

JCI Insight· September 2022

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Prediction of patient outcomes through social determinants of health: The Pulmonary Hypertension Association Registry (PHAR) evaluation.
Dan Grinnan, Le Kang, Christine DeWilde, David Badesch, Raymond Benza, James Klinger

Pulm Circ· July 2022

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Mesenchymal Stromal Cell Extracellular Vesicles: A New Approach for Preventing Bronchopulmonary Dysplasia?
James R Klinger, Michael A Matthay

Am J Respir Crit Care Med· May 2022

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Remote 6-Minute-Walk Testing in Patients with Pulmonary Hypertension: A Pilot Study.
Tess LaPatra, Grayson L Baird, Randi Goodman, Diane Pinder, Maeve Gaffney, James R Klinger

Am J Respir Crit Care Med· April 2022

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Delphi consensus recommendation for optimization of pulmonary hypertension therapy focusing on switching from a phosphodiesterase 5 inhibitor to riociguat.
Franck F Rahaghi, Vijay P Balasubramanian, Robert C Bourge, Charles D Burger, Murali M Chakinala, James R Klinger

Pulm Circ· April 2022

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Effect of dose, dosing intervals, and hypoxic stress on the reversal of pulmonary hypertension by mesenchymal stem cell extracellular vesicles.
James R Klinger, Mandy Pereira, Michael Del Tatto, Mark S Dooner, Sicheng Wen

Pulm Circ· October 2021

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Novel Pharmacological Targets for Pulmonary Arterial Hypertension.
James R Klinger

Compr Physiol· September 2021

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Treatment of Pulmonary Hypertension Associated With COPD: Time for Another Look?
James R Klinger

Chest· August 2021

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