Publications by authors named "James Milnes"

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Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation.
Arne van Hunnik, Vladimír Sobota, Stef Zeemering, Dragan Opacic, Billy Scaf, James T Milnes

Front Physiol· July 2024

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Pharmacological inhibition of acetylcholine-regulated potassium current ( ) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events.
Benedikt Linz, Anne Hauge Thostrup, Arnela Saljic, Karlijn Rombouts, Julie Norup Hertel, James Milnes

Heart Rhythm O2· February 2022

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A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels.
Meng Cui, Yaser Alhamshari, Lucas Cantwell, Said Ei-Haou, Giasemi C Eptaminitaki, James Milnes

J Biol Chem· August 2021

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The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats.
Vladimír Sobota, Giulia Gatta, Arne van Hunnik, Iris van Tuijn, Marion Kuiper, James Milnes

Front Pharmacol· January 2021

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Effect of selective I inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation.
Merle Friederike Fenner, Helena Carstensen, Sarah Dalgas Nissen, Eva Melis Hesselkilde, Christine Scott Lunddahl, James Milnes

Br J Pharmacol· August 2020

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Inhibition of voltage-gated Na currents by eleclazine in rat atrial and ventricular myocytes.
Rachel E Caves, Alexander Carpenter, Stéphanie C Choisy, Ben Clennell, Hongwei Cheng, James T Milnes

Heart Rhythm O2· August 2020

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Lightsheet fluorescence lifetime imaging microscopy with wide-field time-correlated single photon counting.
Liisa M Hirvonen, Jakub Nedbal, Norah Almutairi, Thomas A Phillips, Wolfgang Becker, James Milnes

J Biophotonics· February 2020

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Wide-field time-correlated single photon counting-based fluorescence lifetime imaging microscopy.
Klaus Suhling, Liisa M Hirvonen, Wolfgang Becker, Stefan Smietana, Holger Netz, James Milnes

Nucl Instrum Methods Phys Res A· October 2019

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Genetic variation in causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current ().
Christiaan C Veerman, Isabella Mengarelli, Charlotte D Koopman, Ronald Wilders, Shirley C van Amersfoorth, James Milnes

Dis Model Mech· July 2019

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A wide-field TCSPC FLIM system based on an MCP PMT with a delay-line anode.
Wolfgang Becker, Liisa M Hirvonen, James Milnes, Thomas Conneely, Ottmar Jagutzki

Rev Sci Instrum· September 2016

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The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation.
John Ford, James Milnes, Said El Haou, Erich Wettwer, Simone Loose

Heart Rhythm· February 2016

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Novel K+ Channel Targets in Atrial Fibrillation Drug Development--Where Are We?
Said El-Haou, John W Ford, James T Milnes

J Cardiovasc Pharmacol· November 2015

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Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.
Harsha D Devalla, Verena Schwach, John W Ford, James T Milnes, Said El-Haou

EMBO Mol Med· April 2015

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Effects of IKur blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation.
Simone Loose, Judith Mueller, Erich Wettwer, Michael Knaut, John Ford, James Milnes

Front Pharmacol· March 2014

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Human electrophysiological and pharmacological properties of XEN-D0101: a novel atrial-selective Kv1.5/IKur inhibitor.
John Ford, James Milnes, Erich Wettwer, Torsten Christ, Marc Rogers

J Cardiovasc Pharmacol· May 2013

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Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia.
Shang-Jin Kim, Haifei Zhang, Igor Khaliulin, Stéphanie C M Choisy, Richard Bond, James T Milnes

Circ Arrhythm Electrophysiol· December 2012

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New pharmacological approaches to atrial fibrillation.
James T Milnes, David J Madge, John W Ford

Drug Discov Today· July 2012

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Characterisation of AnBEST1, a functional anion channel in the plasma membrane of the filamentous fungus, Aspergillus nidulans.
Stephen K Roberts, James Milnes, Mark Caddick

Fungal Genet Biol· September 2011

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Imaging visible light with Medipix2.
Aaron Mac Raighne, Colin Brownlee, Ulrike Gebert, Dzmitry Maneuski, James Milnes

Rev Sci Instrum· November 2010

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Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.
James T Milnes, Harry J Witchel, Joanne L Leaney, Derek J Leishman, Jules C Hancox

J Pharmacol Toxicol Methods· June 2010

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New drugs targeting the cardiac ultra-rapid delayed-rectifier current (I Kur): rationale, pharmacology and evidence for potential therapeutic value.
John W Ford, James T Milnes

J Cardiovasc Pharmacol· August 2008

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hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.
James T Milnes, Harry J Witchel, Joanne L Leaney, Derek J Leishman, Jules C Hancox

Biochem Biophys Res Commun· December 2006

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Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656.
John M Ridley, James T Milnes, Rona S Duncan, Mark J McPate, Andrew F James

FEBS Lett· April 2006

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Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.
John M Ridley, James T Milnes, Jules C Hancox, Harry J Witchel

J Mol Cell Cardiol· January 2006

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The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential.
Zhan Gao, James T Milnes, Stéphanie C M Choisy, Michael J Leach, Jules C Hancox

Clin Exp Pharmacol Physiol· December 2005

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