Publications by authors named "James O Wrabl"

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The Ensemble Basis of Allostery and Function: Insights from Models of Local Unfolding.
Charles E F Millard, James O Wrabl, Sarah J Brantley, Emily Grasso, Anna Schmitz

J Mol Biol· October 2025

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Statistical Thermodynamics of the Protein Ensemble: Mediating Function and Evolution.
Vincent J Hilser, James O Wrabl, Charles E F Millard, Anna Schmitz, Sarah J Brantley

Annu Rev Biophys· May 2025

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Impact of local unfolding fluctuations on the evolution of regional sequence preferences in proteins.
Keila Voortman-Sheetz, James O Wrabl, Vincent J Hilser

Protein Sci· March 2025

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A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design.
Srona Sengupta, Josephine Zhang, Madison C Reed, Jeanna Yu, Aeryon Kim, James O Wrabl

J Exp Med· July 2023

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A Thermodynamic Atlas of Proteomes Reveals Energetic Innovation across the Tree of Life.
Alexander F Chin, James O Wrabl, Vincent J Hilser

Mol Biol Evol· March 2022

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Conserved allosteric ensembles in disordered proteins using TROSY/anti-TROSY R-filtered spectroscopy.
Emily M Grasso, Ananya Majumdar, James O Wrabl, Dominique P Frueh, Vincent J Hilser

Biophys J· June 2021

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Tumor Susceptibility Gene 101 Regulates the Glucocorticoid Receptor through Disorder-Mediated Allostery.
Jordan T White, James Rives, Marla E Tharp, James O Wrabl, E Brad Thompson

Biochemistry· June 2021

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Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome.
Min-Hyung Cho, James O Wrabl, James Taylor, Vincent J Hilser

Proc Natl Acad Sci U S A· September 2020

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Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase.
Mark L Sowers, Andrew P P Anderson, James O Wrabl, Y Whitney Yin

J Am Chem Soc· July 2019

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The role of negative selection in protein evolution revealed through the energetics of the native sate ensemble.
Jordan Hoffmann, James O Wrabl, Vincent J Hilser

Proteins· December 2018

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Ensemble allosteric model: energetic frustration within the intrinsically disordered glucocorticoid receptor.
Jordan T White, Jing Li, Emily Grasso, James O Wrabl, Vincent J Hilser

Philos Trans R Soc Lond B Biol Sci· June 2018

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Dynamic allostery can drive cold adaptation in enzymes.
Harry G Saavedra, James O Wrabl, Jeremy A Anderson, Jing Li, Vincent J Hilser

Nature· June 2018

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Correction: Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor.
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh

Elife· February 2018

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Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor.
Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh

Elife· October 2017

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The role of negative selection in protein evolution revealed through the energetics of the native state ensemble.
Jordan Hoffmann, James O Wrabl, Vincent J Hilser

Proteins· April 2016

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A horizontal alignment tool for numerical trend discovery in sequence data: application to protein hydropathy.
Omar Hadzipasic, James O Wrabl, Vincent J Hilser

PLoS Comput Biol· May 2014

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The ensemble nature of allostery.
Hesam N Motlagh, James O Wrabl, Jing Li, Vincent J Hilser

Nature· April 2014

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Conformational heterogeneity within the LID domain mediates substrate binding to Escherichia coli adenylate kinase: function follows fluctuations.
Travis P Schrank, James O Wrabl, Vincent J Hilser

Top Curr Chem· December 2013

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Structural and energetic basis of allostery.
Vincent J Hilser, James O Wrabl, Hesam N Motlagh

Annu Rev Biophys· March 2013

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The role of protein conformational fluctuations in allostery, function, and evolution.
James O Wrabl, Jenny Gu, Tong Liu, Travis P Schrank, Steven T Whitten

Biophys Chem· November 2011

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Investigating homology between proteins using energetic profiles.
James O Wrabl, Vincent J Hilser

PLoS Comput Biol· March 2010

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An energetic representation of protein architecture that is independent of primary and secondary structure.
Jason Vertrees, James O Wrabl, Vincent J Hilser

Biophys J· September 2009

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Energetic profiling of protein folds.
Jason Vertrees, James O Wrabl, Vincent J Hilser

Methods Enzymol· May 2009

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The torsin-family AAA+ protein OOC-5 contains a critical disulfide adjacent to Sensor-II that couples redox state to nucleotide binding.
Li Zhu, James O Wrabl, Adam P Hayashi, Lesilee S Rose, Philip J Thomas

Mol Biol Cell· August 2008

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Statistics of random protein superpositions: p-values for pairwise structure alignment.
James O Wrabl, Nick V Grishin

J Comput Biol· April 2008

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