Publications by authors named "James R Edwards"

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PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease.
Kathryn Frost, Alyssa Urbanowski, Georgiana Neag, Jonathan W Lewis, Ellie Northall, James R Edwards

Biomed Pharmacother· October 2025

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Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.
Jinsen Lu, Srinivasa Rao Rao, Helen Knowles, Haoqun Zhan, Beatriz Gamez, James R Edwards

bioRxiv· March 2025

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Exploring the potential of laser-textured metal alloys: Fine-tuning vascular cells responses through and analysis.
Indong Jun, Haneul Choi, Hyeok Kim, Byoung Chan Choi, Hye Jung Chang, James R Edwards

Bioact Mater· January 2025

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ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells.
Laura Carretero-Iglesia, Olivia J Hall, Jérémy Berret, Daniela Pais, Carole Estoppey, Claire M Edwards, James R Edwards

Nat Cancer· October 2024

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Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.
Jonathan W Lewis, Kathryn Frost, Georgiana Neag, Mussarat Wahid, Melissa Finlay, James R Edwards

Cell Rep Med· August 2024

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Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.
Jonathan W Lewis, Kathryn Frost, Georgiana Neag, Mussarat Wahid, Melissa Finlay, James R Edwards

Cell Rep Med· May 2024

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The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse.
Kathryn Frost, Jonathan W Lewis, Simon W Jones, James R Edwards, Amy J Naylor

Int J Mol Sci· May 2024

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Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma.
Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Claire M Edwards, James R Edwards

Blood· July 2023

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and effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L Doolittle, James R Edwards

Aging (Albany NY)· May 2023

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and effects of zoledronate on senescence and senescence-associated secretory phenotype markers.
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L Doolittle, James R Edwards

bioRxiv· February 2023

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Biomimetic hydrogel blanket for conserving and recovering intrinsic cell properties.
Seung-Hoon Um, Youngmin Seo, Hyunseon Seo, Kyungwoo Lee, Sun Hwa Park, James R Edwards

Biomater Res· December 2022

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Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival.
Jessica Whitburn, Srinivasa R Rao, Emma V Morris, Sho Tabata, Akiyoshi Hirayama, James R Edwards, Claire M Edwards

Sci Adv· February 2022

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The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo.
Beatriz Gámez, Emma V Morris, Sam W Z Olechnowicz, Siobhan Webb, James R Edwards, Claire M Edwards

Transl Oncol· January 2022

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On/off switchable physical stimuli regulate the future direction of adherent cellular fate.
Indong Jun, Hyung-Seop Han, Jae Won Lee, Kyungwoo Lee, Yu-Chan Kim, James R Edwards

J Mater Chem B· July 2021

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Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020.
Jonathan H Tobias, Emma L Duncan, Erika Kague, Chrissy L Hammond, Celia L Gregson, James R Edwards

Front Endocrinol (Lausanne)· May 2021

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Adiponectin signalling in bone homeostasis, with age and in disease.
Jonathan W Lewis, James R Edwards, Amy J Naylor, Helen M McGettrick

Bone Res· January 2021

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Biodegradable Magnesium Alloys Promote Angio-Osteogenesis to Enhance Bone Repair.
Hyung-Seop Han, Indong Jun, Hyun-Kwang Seok, Kang-Sik Lee, Kyungwoo Lee, James R Edwards

Adv Sci (Weinh)· August 2020

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SIRT1 directly activates autophagy in human chondrocytes.
Pradeep K Sacitharan, George Bou-Gharios, James R Edwards

Cell Death Discov· May 2020

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Modeling the Human Bone-Tumor Niche: Reducing and Replacing the Need for Animal Data.
Srinivasa R Rao, Claire M Edwards, James R Edwards

JBMR Plus· April 2020

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Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment.
Sam W Z Olechnowicz, Megan M Weivoda, Seint T Lwin, Szi K Leung, Sarah Gooding, James R Edwards, Claire M Edwards

Sci Rep· October 2019

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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Sarah Gooding, Sam W Z Olechnowicz, Emma V Morris, Andrew E Armitage, Joao Arezes, James R Edwards, Claire M Edwards

Nat Commun· October 2019

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Small Animal Video Tracking for Activity and Path Analysis Using a Novel Open-Source Multi-Platform Application (AnimApp).
Srinivasa R Rao, Sam W Z Olechnowicz, Patrick Krätschmer, James E C Jepson, Claire M Edwards, James R Edwards

Sci Rep· August 2019

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Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300: response to correspondence by Borzì et al.
Pradeep K Sacitharan, George Bou Gharios, James R Edwards

Exp Mol Med· March 2019

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Transgenic zebrafish model for quantification and visualization of tissue toxicity caused by alloying elements in newly developed biodegradable metal.
Hyung-Seop Han, Gun Hyuk Jang, Indong Jun, Hyunseon Seo, Jimin Park, James R Edwards

Sci Rep· September 2018

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Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300.
Pradeep K Sacitharan, Seint Lwin, George Bou Gharios, James R Edwards

Exp Mol Med· September 2018

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