Publications by authors named "James S Butler"

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The Current Landscape for Human Papillomavirus Vaccination in Oropharyngeal Carcinoma.
Nivedha Kumar, James S Butler, Jay Vashisht

Cancer J· June 2025

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CRISPR-Based Therapy for Hereditary Angioedema.
Danny M Cohn, Padmalal Gurugama, Markus Magerl, Constance H Katelaris, David Launay, James S Butler

N Engl J Med· January 2025

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CRISPR-Cas9 In Vivo Gene Editing of for Hereditary Angioedema.
Hilary J Longhurst, Karen Lindsay, Remy S Petersen, Lauré M Fijen, Padmalal Gurugama, James S Butler

N Engl J Med· February 2024

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Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model.
Paul J Schmidt, Kevin Fitzgerald, James S Butler, Mark D Fleming

Am J Hematol· February 2021

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Mild iron deficiency does not ameliorate the phenotype of a murine erythropoietic protoporphyria model.
Paul J Schmidt, Monica L Hollowell, Kevin Fitzgerald, James S Butler, Mark D Fleming

Am J Hematol· May 2020

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RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β-thalassemia intermedia.
Paul J Schmidt, Kaifeng Liu, Gary Visner, Kevin Fitzgerald, Shannon Fishman, James S Butler

Am J Hematol· June 2018

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Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.
Jennifer L S Willoughby, Amy Chan, Alfica Sehgal, James S Butler, Jayaprakash K Nair

Mol Ther· January 2018

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Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.
James S Butler, Amy Chan, Susete Costelha, Shannon Fishman, Jennifer L S Willoughby

Amyloid· June 2016

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Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.
Paul J Schmidt, Tim Racie, Mark Westerman, Kevin Fitzgerald, James S Butler

Am J Hematol· April 2015

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A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis.
Patrick Gutschow, Paul J Schmidt, Huiling Han, Vaughn Ostland, Thomas B Bartnikas, James S Butler

Haematologica· February 2015

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Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
Teresa Coelho, David Adams, Ana Silva, Pierre Lozeron, Philip N Hawkins, James S Butler

N Engl J Med· August 2013

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Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles.
Tomoko Nakayama, James S Butler, Alfica Sehgal, Mariano Severgnini, Tim Racie

Mol Ther· August 2012

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Clinical outcomes in extracranial tumor sites and unusual toxicities with concurrent whole brain radiation (WBRT) and Erlotinib treatment in patients with non-small cell lung cancer (NSCLC) with brain metastasis.
Inan Olmez, Bernadine R Donahue, James S Butler, Yiwu Huang, Philip Rubin

Lung Cancer· November 2010

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Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, James S Butler

Mol Ther· July 2010

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Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function.
David J Lubin, James S Butler, Stewart N Loh

J Mol Biol· January 2010

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Structural and thermodynamic analysis of a conformationally strained circular permutant of barnase.
James S Butler, Diana M Mitrea, Gregory Mitrousis, Gino Cingolani, Stewart N Loh

Biochemistry· April 2009

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Dynamics of equilibrium structural fluctuations of apomyoglobin measured by fluorescence correlation spectroscopy.
Huimin Chen, Elizabeth Rhoades, James S Butler, Stewart N Loh, Watt W Webb

Proc Natl Acad Sci U S A· June 2007

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Zn(2+)-dependent misfolding of the p53 DNA binding domain.
James S Butler, Stewart N Loh

Biochemistry· March 2007

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Folding and misfolding mechanisms of the p53 DNA binding domain at physiological temperature.
James S Butler, Stewart N Loh

Protein Sci· November 2006

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Modular enzyme design: regulation by mutually exclusive protein folding.
Jeung-Hoi Ha, James S Butler, Diana M Mitrea, Stewart N Loh

J Mol Biol· April 2006

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Kinetic partitioning during folding of the p53 DNA binding domain.
James S Butler, Stewart N Loh

J Mol Biol· July 2005

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Bacteriophage P22 tail accessory factor GP26 is a long triple-stranded coiled-coil.
Dewan Andrews, James S Butler, Jawdat Al-Bassam, Lisa Joss, Danella A Winn-Stapley

J Biol Chem· February 2005

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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain.
James S Butler, Stewart N Loh

Biochemistry· March 2003

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