Publications by authors named "James Simpkins"

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Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic.
James W Simpkins, Ralph L Cooper, Charles Breckenridge

Toxicol In Vitro· March 2026

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Comparative visible-light and near-infrared fluorescence detection of microRNA in blood plasma with paper lateral flow test strips.
Xuefei Gao, Yingjie Hang, Jennifer Boryczka, Weirui Tan, Peng Zheng, James W Simpkins

Biosens Bioelectron· December 2025

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Mid-life exposure to chronic stress accelerates cerebrovascular dysfunction and upregulates oxidative stress in Alzheimer's disease mice.
Saina S Prabhu, Emily N Burrage, Tyler Coblentz, Steven Ball, Dharendra Thapa, James W Simpkins

J Alzheimers Dis· September 2025

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Brain-Wide Transgene Expression in Mice by Systemic Injection of Genetically Engineered Exosomes: CAP-Exosomes.
Saumyendra N Sarkar, Deborah Corbin, James W Simpkins

Pharmaceuticals (Basel)· February 2024

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Acute exposure to artificial light at night alters hippocampal vascular structure in mice.
Jacob R Bumgarner, William H Walker, Dominic D Quintana, Rhett C White, Alexandra A Richmond, James W Simpkins

iScience· July 2023

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Spatiotemporal Correlation Analysis of Hydraulic Fracturing and Stroke in the United States.
Chuanbo Hu, Bin Liu, Shuo Wang, Zhenduo Zhu, Amelia Adcock, James Simpkins

Int J Environ Res Public Health· August 2022

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miR-146a Dysregulates Energy Metabolism During Neuroinflammation.
Sujung Jun Kim, Ashley E Russell, Wei Wang, Darren E Gemoets, Saumyendra N Sarkar, James W Simpkins

J Neuroimmune Pharmacol· June 2022

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Intermittent Lipopolysaccharide Exposure Significantly Increases Cortical Infarct Size and Impairs Autophagy.
Ashley E Russell, John Z Cavendish, Ali Rai, Mya Vannoy, Ahmad H Dakhlallah, James W Simpkins

ASN Neuro· January 2022

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Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice.
Dominic D Quintana, Yamini Anantula, Jorge A Garcia, Elizabeth B Engler-Chiurazzi, Saumyendra N Sarkar, James W Simpkins

Neurobiol Aging· September 2021

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Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells.
Dominic D Quintana, Jorge A Garcia, Yamini Anantula, Stephanie L Rellick, Elizabeth B Engler-Chiurazzi, James W Simpkins

J Alzheimers Dis· May 2021

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The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.
Pushkar Saralkar, Alexander Mdzinarishvili, Tasneem A Arsiwala, Yoon-Kwang Lee, Patrick G Sullivan, James Simpkins

Pharm Res· May 2021

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Author Correction: Blood substitution therapy rescues the brain of mice from ischemic damage.
Xuefang Ren, Heng Hu, Imran Farooqi, James W Simpkins

Nat Commun· May 2021

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A "hot Spot"-Enhanced paper lateral flow assay for ultrasensitive detection of traumatic brain injury biomarker S-100β in blood plasma.
Xuefei Gao, Jennifer Boryczka, Peng Zheng, Sujan Kasani, Feng Yang, James W Simpkins

Biosens Bioelectron· April 2021

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IL-1β Antibody Protects Brain from Neuropathology of Hypoperfusion.
Dominic Quintana, Xuefang Ren, Heng Hu, Deborah Corbin, Elizabeth Engler-Chiurazzi, James Simpkins

Cells· April 2021

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Mitochondrial Movement and Number Deficits in Embryonic Cortical Neurons from 3xTg-AD Mice.
John Z Cavendish, Saumyendra N Sarkar, Mark A Colantonio, Dominic D Quintana, Nadia Ahmed, James W Simpkins

J Alzheimers Dis· September 2020

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Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke.
Sajad Sarvari, Faezeh Moakedi, Emily Hone, James W Simpkins, Xuefang Ren

Metab Brain Dis· August 2020

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Blood substitution therapy rescues the brain of mice from ischemic damage.
Xuefang Ren, Heng Hu, Imran Farooqi, James W Simpkins

Nat Commun· August 2020

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Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner.
Keyana N Porter, Saumyendra N Sarkar, Duaa A Dakhlallah, Mya E Vannoy, Dominic D Quintana, James W Simpkins

Front Aging Neurosci· April 2020

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MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes.
Heng Hu, Emily A Hone, Edward A P Provencher, Samuel A Sprowls, Imran Farooqi, James W Simpkins

Sci Rep· February 2020

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MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia.
Xuefang Ren, Elizabeth B Engler-Chiurazzi, Ashley E Russell, Saumyendra N Sarkar, Stephanie L Rellick, James W Simpkins

Neurochem Int· July 2019

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Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy.
Dominic D Quintana, Jorge A Garcia, Saumyendra N Sarkar, Sujung Jun, Elizabeth B Engler-Chiurazzi, James W Simpkins

Mitochondrion· July 2019

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Not all clots are created equal: a review of deficient thrombolysis with tissue plasminogen activator (tPA) in patients with metabolic syndrome.
Charles I Mosimah, Pamela J Murray, James W Simpkins

Int J Neurosci· June 2019

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MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma.
Saumyendra N Sarkar, Ashley E Russell, Elizabeth B Engler-Chiurazzi, Keyana N Porter, James W Simpkins

Aging Dis· April 2019

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Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system.
Neil T Sprenkle, Anirudhya Lahiri, James W Simpkins, Gordon P Meares

J Neurochem· February 2019

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Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells.
Ashley E Russell, Sujung Jun, Saumyendra Sarkar, Werner J Geldenhuys, Sara E Lewis, James W Simpkins

Front Cell Neurosci· February 2019

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