Publications by authors named "James Trudell"

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Modulation of α1β3γ2 GABA receptors expressed in oocytes using a propofol photoswitch tethered to the transmembrane helix.
Cecilia M Borghese, Hua-Yu L Wang, Stanton F McHardy, Robert O Messing, James R Trudell

Proc Natl Acad Sci U S A· February 2021

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Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity.
Maya Popova, Larry Rodriguez, James R Trudell, Sylvia Nguyen, Michael Bloomfield

Int J Mol Sci· April 2020

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An intersubunit electrostatic interaction in the GABA receptor facilitates its responses to benzodiazepines.
Natasha C Pflanz, Anna W Daszkowski, Garrett L Cornelison, James R Trudell, S John Mihic

J Biol Chem· May 2018

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Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.
Mandy L McCracken, Giorgio Gorini, Lindsay M McCracken, R Dayne Mayfield, R Adron Harris, James R Trudell

Front Mol Neurosci· July 2016

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Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors.
Cecilia M Borghese, Carlos I Ruiz, Ui S Lee, Madeline A Cullins, Edward J Bertaccini, James R Trudell

ACS Chem Neurosci· January 2016

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Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.
Suzzane Horani, Evan P Stater, Pierre-Jean Corringer, James R Trudell, R Adron Harris

Alcohol Clin Exp Res· June 2015

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Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.
Rebecca J Howard, James R Trudell, R Adron Harris

Pharmacol Rev· December 2014

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Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Anna Naito, Karan H Muchhala, Liana Asatryan, James R Trudell, Gregg E Homanics

Mol Pharmacol· December 2014

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Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics.
Edward J Bertaccini, Robert Dickinson, James R Trudell, Nicholas P Franks

ACS Chem Neurosci· December 2014

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Alcohol dependence: molecular and behavioral evidence.
James R Trudell, Robert O Messing, Jody Mayfield, R Adron Harris

Trends Pharmacol Sci· July 2014

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P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders.
Kelle M Franklin, Liana Asatryan, Michael W Jakowec, James R Trudell, Richard L Bell

Front Neurosci· July 2014

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Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.
Liana Asatryan, Megan M Yardley, Sheraz Khoja, James R Trudell, Nhat Hyunh

Int J Neuropsychopharmacol· June 2014

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Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors.
Tamás Kálai, Robin Altman, Izumi Maezawa, Mária Balog, Christophe Morisseau, James R Trudell

Eur J Med Chem· April 2014

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Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.
Richard W Olsen, Guo-Dong Li, Martin Wallner, James R Trudell, Edward J Bertaccini

Alcohol Clin Exp Res· March 2014

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GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites.
Cecilia M Borghese, Jessica A Hicks, Daniel J Lapid, James R Trudell, R Adron Harris

J Neurochem· February 2014

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Endothelial fate mapping in mice with pulmonary hypertension.
Lina Qiao, Toshihiko Nishimura, Lingfang Shi, Dane Sessions, Ama Thrasher, James R Trudell

Circulation· February 2014

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Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.
Maya Popova, James Trudell, Kaixun Li, Ronald Alkana, Daryl Davies

Purinergic Signal· December 2013

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Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.
Lindsay M McCracken, James R Trudell, Mandy L McCracken, R Adron Harris

Alcohol Clin Exp Res· December 2013

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Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.
Edward J Bertaccini, Ozge Yoluk, Erik R Lindahl, James R Trudell

Anesthesiology· November 2013

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Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.
Torben Brömstrup, Rebecca J Howard, James R Trudell, R Adron Harris, Erik Lindahl

Structure· August 2013

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Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin.
Ozge Yoluk, Torben Brömstrup, Edward J Bertaccini, James R Trudell, Erik Lindahl

Biophys J· August 2013

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.
Samuel Murail, Rebecca J Howard, Torben Broemstrup, Edward J Bertaccini, R Adron Harris, James R Trudell

PLoS Comput Biol· May 2013

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Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo.
Lindsay M McCracken, Yuri A Blednov, James R Trudell, Jillian M Benavidez, Heinrich Betz

J Pharmacol Exp Ther· February 2013

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Induced changes in protein receptors conferring resistance to anesthetics.
Edward J Bertaccini, James R Trudell

Curr Opin Anaesthesiol· August 2012

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Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.
Daya I Perkins, James R Trudell, Liana Asatryan, Daryl L Davies, Ronald L Alkana

J Pharmacol Exp Ther· May 2012

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