Publications by authors named "James W Freeman"

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Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching.
Chen Chen, Shujie Zhao, Xiangru Zhao, Lin Cao, Anand Karnad, James W Freeman

Cell Death Dis· August 2022

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The biology and role of CD44 in cancer progression: therapeutic implications.
Chen Chen, Shujie Zhao, Anand Karnad, James W Freeman

J Hematol Oncol· May 2018

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Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells.
Jingjing Gong, Amanda R Muñoz, Subramanya Pingali, Florastina Payton-Stewart, Daniel E Chan, James W Freeman

Mol Carcinog· February 2017

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CD44 Expression Level and Isoform Contributes to Pancreatic Cancer Cell Plasticity, Invasiveness, and Response to Therapy.
Shujie Zhao, Chen Chen, Katherine Chang, Anand Karnad, Jaishree Jagirdar, James W Freeman

Clin Cancer Res· November 2016

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A miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancer.
Alakesh Bera, Kolaparthi VenkataSubbaRao, Muthu Saravanan Manoharan, Ping Hill, James W Freeman

PLoS One· May 2015

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Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Zhe Chang, Huaiqiang Ju, Jianhua Ling, Zhuonan Zhuang, Zhongkui Li, James W Freeman

PLoS One· March 2015

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Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets.
Katherine Chang, Anand Karnad, Shujie Zhao, James W Freeman

Oncotarget· February 2015

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Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
Alakesh Bera, Shujie Zhao, Lin Cao, Paul J Chiao, James W Freeman

PLoS One· September 2014

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Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer.
Jingjing Gong, Jianping Xie, Roble Bedolla, Paul Rivas, Divya Chakravarthy, James W Freeman

Clin Cancer Res· March 2014

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Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer.
Kolaparthi Venkatasubbarao, Lindsay Peterson, Shujie Zhao, Ping Hill, Lin Cao, James W Freeman

Mol Cancer· September 2013

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Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor-mediated cancer cell invasion.
Amalraj Thangasamy, Jessica Rogge, Naveen K Krishnegowda, James W Freeman, Sudhakar Ammanamanchi

J Biol Chem· September 2011

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Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
Shujie Zhao, Yubao Wang, Lin Cao, Michel M Ouellette, James W Freeman

Int J Cancer· November 2010

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Epigenetic modulation and attacking the hedgehog pathway: potentially synergistic therapeutic targets for pancreatic cancer.
James W Freeman, Yubao Wang, Francis J Giles

Cancer Biol Ther· July 2009

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Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.
Shujie Zhao, Kolaparthi Venkatasubbarao, Jillian W Lazor, Jane Sperry, Changqing Jin, James W Freeman

Cancer Res· June 2008

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Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.
Shujie Zhao, Sudhakar Ammanamanchi, Michael Brattain, Lin Cao, Amalraj Thangasamy, James W Freeman

J Biol Chem· April 2008

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Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.
Kolaparthi Venkatasubbarao, Ahsan Choudary, James W Freeman

Cancer Res· April 2005

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Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.
Weiqi Huang, Shujie Zhao, Sudhakar Ammanamanchi, Michael Brattain, Kolaparthi Venkatasubbarao, James W Freeman

J Biol Chem· March 2005

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Alterations of cell signaling pathways in pancreatic cancer.
James W Freeman, Daniel DeArmond, Michael Lake, Weiqi Huang, Kolaparthi Venkatasubbarao

Front Biosci· May 2004

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Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
Daniel DeArmond, Michael G Brattain, John Milburn Jessup, Jeffrey Kreisberg, Shazli Malik, James W Freeman

Oncogene· October 2003

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Acetylated sp3 is a transcriptional activator.
Sudhakar Ammanamanchi, James W Freeman, Michael G Brattain

J Biol Chem· September 2003

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Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells.
Shujie Zhao, Kolaparthi Venkatasubbarao, Senlin Li, James W Freeman

Cancer Res· May 2003

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Rap1 reverses transcriptional repression of TGF-beta type II receptor by a mechanism involving AP-1 in the human pancreatic cancer cell line, UK Pan-1.
Kimberly D Fralix, Shujie Zhao, Kolaparthi Venkatasubbarao, James W Freeman

J Cell Physiol· January 2003

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Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2.
Mansoor M Ahmed, Rachael A Alcock, Damodaran Chendil, Swatee Dey, Anindita Das, James W Freeman

J Biol Chem· January 2002

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