Publications by authors named "Jan B Koenderink"

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Inhibitory potential of phytochemicals on species-specific breast cancer resistance protein transport activity.
Lérica le Roux-Pullen, Jeroen J M W van den Heuvel, Ilse R Dubbelboer, Frans G M Russel, Ronette Gehring, Jan B Koenderink

Toxicol In Vitro· December 2025

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Dicloxacillin and flucloxacillin inhibit hepatic uptake transporters -in vitro investigations and physiologically based pharmacokinetic modelling.
Noora Sjöstedt, Ogochukwu U Amaeze, Jeroen Jmw van den Heuvel, Tore B Stage, Jan B Koenderink

bioRxiv· October 2025

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In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3.
Jochem Louisse, Lorenzo Pedroni, Jeroen J M W van den Heuvel, Deborah Rijkers, Liz Leenders, Jan B Koenderink

Toxicology· December 2024

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In vitro screening model for compound interactions with human and dairy animal BCRP orthologs.
Lérica Le Roux-Pullen, Jeroen J M W Van den Heuvel, Noraly B Jonis, Tom Scheer-Weijers, Ilse R Dubbelboer, Jan B Koenderink

J Vet Pharmacol Ther· September 2024

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Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies.
Charlotte A Hoogstraten, Jan B Koenderink, Carolijn E van Straaten, Tom Scheer-Weijers, Jan A M Smeitink

Toxicol In Vitro· March 2024

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Transporter-Mediated Cellular Distribution of Tyrosine Kinase Inhibitors as a Potential Resistance Mechanism in Chronic Myeloid Leukemia.
Noor E Verhagen, Jan B Koenderink, Nicole M A Blijlevens, Jeroen J W M Janssen, Frans G M Russel

Pharmaceutics· October 2023

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The potential role of drug transporters and amikacin modifying enzymes in M. avium.
Jodie A Schildkraut, Jordy P M Coolen, Carolien Ruesen, Jeroen J M W van den Heuvel, Laura Edo Aceña, Jan B Koenderink

J Glob Antimicrob Resist· September 2023

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Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis.
Carlijn H C Litjens, Laurens F M Verscheijden, Elin M Svensson, Petra H H van den Broek, Hedwig van Hove, Jan B Koenderink

Antibiotics (Basel)· April 2023

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Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4).
Jochem Louisse, Luca Dellafiora, Jeroen J M W van den Heuvel, Deborah Rijkers, Liz Leenders, Jan B Koenderink

Arch Toxicol· March 2023

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coding for LAT2 is associated with early disease progression in osteosarcoma and transports doxorubicin.
Evelien G E Hurkmans, Jan B Koenderink, Jeroen J M W van den Heuvel, Yvonne M H Versleijen-Jonkers, Melissa H S Hillebrandt-Roeffen

Front Pharmacol· November 2022

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Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling.
Carlijn H C Litjens, Laurens F M Verscheijden, Celine Bolwerk, Rick Greupink, Jan B Koenderink

J Clin Pharmacol· March 2022

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The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.
Wilma Kiander, Kati-Sisko Vellonen, Melina M Malinen, Mikko Gynther, Marja Hagström, Jan B Koenderink

Pharm Res· October 2021

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Differences in P-glycoprotein activity in human and rodent blood-brain barrier assessed by mechanistic modelling.
Laurens F M Verscheijden, Jan B Koenderink, Saskia N de Wildt, Frans G M Russel

Arch Toxicol· September 2021

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Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.
Laurens F M Verscheijden, Carlijn H C Litjens, Jan B Koenderink, Ron H J Mathijssen, Marcel M Verbeek

PLoS Comput Biol· March 2021

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Food Additives as Inhibitors of Intestinal Drug Transporter OATP2B1.
Alli Tikkanen, Estelle Pierrot, Feng Deng, Virginia Barras Sánchez, Marja Hagström, Jan B Koenderink

Mol Pharm· October 2020

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Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates.
Jan B Koenderink, Jeroen J M W van den Heuvel, Ab Bilos, Galvin Vredenburg, Nico P E Vermeulen

Arch Toxicol· September 2020

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Rifampicin Transport by OATP1B1 Variants.
Carlijn H C Litjens, Jeroen J M W van den Heuvel, Frans G M Russel, Rob E Aarnoutse, Lindsey H M Te Brake, Jan B Koenderink

Antimicrob Agents Chemother· September 2020

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Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule.
Nori J L Smeets, Carlijn H C Litjens, Jeroen J M W van den Heuvel, Hedwig van Hove, Petra van den Broek, Jan B Koenderink

Pharmaceutics· September 2020

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Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
Laurens F M Verscheijden, Jan B Koenderink, Trevor N Johnson, Saskia N de Wildt, Frans G M Russel

Pharmacol Ther· July 2020

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Efflux transport of nicotine, cotinine and trans-3'-hydroxycotinine glucuronides by human hepatic transporters.
Erkka Järvinen, Noora Sjöstedt, Jan B Koenderink, Heidi Kidron, Moshe Finel

Basic Clin Pharmacol Toxicol· December 2019

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Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).
Anne Zwartsen, Carlijn H C Litjens, Laura Hondebrink, Jeroen J M W van den Heuvel, Rick Greupink, Jan B Koenderink

Toxicology· June 2019

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Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis.
Laurens F M Verscheijden, Jan B Koenderink, Saskia N de Wildt, Frans G M Russel

PLoS Comput Biol· June 2019

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Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity.
Karl M Weigand, Tom J J Schirris, Megan Houweling, Jeroen J M W van den Heuvel, Jan B Koenderink

Toxicol In Vitro· April 2019

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Rifampicin Alters Metformin Plasma Exposure but Not Blood Glucose Levels in Diabetic Tuberculosis Patients.
Lindsey H M Te Brake, Vycke Yunivita, Resvi Livia, Nanny Soetedjo, Eleonora van Ewijk-Beneken Kolmer, Jan B Koenderink

Clin Pharmacol Ther· March 2019

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Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates.
Maarten van der Velden, Albert Bilos, Jeroen J M W van den Heuvel, Sanna R Rijpma, Evelien G E Hurkmans, Jan B Koenderink

Malar J· October 2017

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