Publications by authors named "Jan Bevernage"

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In vitro evaluation of drug presence in the upper small intestine when antro-duodenal drug transfer of a highly permeable drug occurs after a high-calorie, high-fat meal.
Shirin Dietrich, Spyridoula Karagianni, Jens Ceulemans, Eline Hermans, Jan Bevernage

Eur J Pharm Sci· September 2025

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Assessing potential of precipitation inhibitors to prevent precipitation during dispersion and digestion of lipid-based formulations using in-line analytics.
Lotte Ejskjær, Kristof Kimpe, Hugo Bohets, Jan Bevernage, Brendan T Griffin

J Pharm Sci· September 2025

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Understanding drug solubilization in intestinal mixed micelles through molecular dynamics simulations.
Fatmegyul Mustan, Nikola Genchev, Liliya Vinarova, Jan Bevernage, Christophe Tistaert

J Colloid Interface Sci· April 2025

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Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates.
Zahari Vinarov, Christophe Tistaert, Jan Bevernage, Hugo Bohets, Patrick Augustijns

Int J Pharm· January 2024

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Screening for Differences in Early Exposure in the Fasted State with in Vitro Methodologies can be Challenging: Experience with the BioGIT System.
Christina Kostantini, Evanthia Spilioti, Jan Bevernage, Jens Ceulemans, Simone Hansmann

J Pharm Sci· August 2023

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Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis.
Christina Kostantini, Evanthia Spilioti, Jan Bevernage, Jens Ceulemans, Simone Hansmann

Int J Pharm· March 2023

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Linking Intrinsic Dissolution Rate and Thermodynamic Solubility with Pharmacokinetic Profiles of Bedaquiline Long-Acting Aqueous Microsuspensions in Rats.
Vy Nguyen, Jan Bevernage, Nicolas Darville, Christophe Tistaert, Jan Van Bocxlaer

Mol Pharm· March 2021

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IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.
Amais Ahmad, Xavier Pepin, Leon Aarons, Yuya Wang, Adam S Darwich, Jan Bevernage

Eur J Pharm Biopharm· November 2020

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Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary.
Masoud Jamei, Bertil Abrahamsson, Jonathan Brown, Jan Bevernage, Michael B Bolger

Eur J Pharm Biopharm· October 2020

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Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation.
Philippe Berben, Lee Ashworth, Stefania Beato, Jan Bevernage, Jean-Luc Bruel

Eur J Pharm Biopharm· July 2019

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Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis.
An Van den Bergh, Sandy Van Hemelryck, Jan Bevernage, Achiel Van Peer, Marcus Brewster

Mol Pharm· July 2018

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Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method.
Jakob Plum, Cecilie M Madsen, Alexandra Teleki, Jan Bevernage, Claudia da Costa Mathews

Mol Pharm· December 2017

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IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds.
Alison Margolskee, Adam S Darwich, Xavier Pepin, Shriram M Pathak, Michael B Bolger, Jan Bevernage

Eur J Pharm Sci· January 2017

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IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.
Adam S Darwich, Alison Margolskee, Xavier Pepin, Leon Aarons, Aleksandra Galetin, Jan Bevernage

Eur J Pharm Sci· January 2017

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IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.
Alison Margolskee, Adam S Darwich, Xavier Pepin, Leon Aarons, Aleksandra Galetin, Jan Bevernage

Eur J Pharm Sci· January 2017

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Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs.
Sara B E Andersson, Caroline Alvebratt, Jan Bevernage, Damien Bonneau, Claudia da Costa Mathews

J Pharm Sci· September 2016

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Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.
Jan Bevernage, Joachim Brouwers, Marcus E Brewster, Patrick Augustijns

Int J Pharm· August 2013

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Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine.
Nico Holmstock, Tom De Bruyn, Jan Bevernage, Pieter Annaert, Raf Mols

Eur J Pharm Sci· April 2013

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Drug precipitation-permeation interplay: supersaturation in an absorptive environment.
Jan Bevernage, Joachim Brouwers, Pieter Annaert, Patrick Augustijns

Eur J Pharm Biopharm· October 2012

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Supersaturation in human gastric fluids.
Jan Bevernage, Bart Hens, Joachim Brouwers, Jan Tack, Pieter Annaert

Eur J Pharm Biopharm· May 2012

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Excipient-mediated supersaturation stabilization in human intestinal fluids.
Jan Bevernage, Thomas Forier, Joachim Brouwers, Jan Tack, Pieter Annaert

Mol Pharm· April 2011

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Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.
Jan Bevernage, Joachim Brouwers, Sarah Clarysse, Maria Vertzoni, Jan Tack

J Pharm Sci· November 2010

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