Publications by authors named "Jan Detka"

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First Sustainable One-Pot Tandem Hantzsch Multicomponent Reaction/Click Reaction Approach for Novel Multitarget-Directed Ligands in Alzheimer's Disease.
Paul J Bernard, Anna Więckowska, Sylvain Grosjean, Justyna Godyń, Kinga Sałat, Jan Detka

ACS Chem Neurosci· December 2025

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Transforming ureas into carbamates: From allosteric p38α MAPK ligands to dual BChE/p38α MAPK inhibitors.
Svit Ferjančič Benetik, Anže Meden, Damijan Knez, Peter Mastnak-Sokolov, Urban Košak, Jan Detka

Bioorg Chem· October 2025

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Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors.
Svit Ferjančič Benetik, Matic Proj, Damijan Knez, Urban Košak, Anže Meden, Jan Detka

J Med Chem· August 2025

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p38α Mitogen-Activated Protein Kinase-An Emerging Drug Target for the Treatment of Alzheimer's Disease.
Jan Detka, Natalia Płachtij, Martyna Strzelec, Aleksandra Manik, Kinga Sałat

Molecules· September 2024

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Immunomodulation-a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system.
Martyna Strzelec, Jan Detka, Patrycja Mieszczak, Małgorzata Katarzyna Sobocińska, Marcin Majka

Front Immunol· March 2023

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The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression.
Katarzyna Głombik, Magdalena Kukla-Bartoszek, Katarzyna Curzytek, Jan Detka, Agnieszka Basta-Kaim

Int J Mol Sci· January 2023

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Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism.
Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek, Alicja Maciejska, Bogusława Budziszewska

Pharmacol Rep· October 2022

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Hormonal Regulation of Oxidative Phosphorylation in the Brain in Health and Disease.
Katarzyna Głombik, Jan Detka, Bogusława Budziszewska

Cells· October 2021

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Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression.
Jan Detka, Katarzyna Głombik

Pharmacol Rep· August 2021

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Venlafaxine and L-Thyroxine Treatment Combination: Impact on Metabolic and Synaptic Plasticity Changes in an Animal Model of Coexisting Depression and Hypothyroidism.
Katarzyna Głombik, Jan Detka, Bogusława Budziszewska

Cells· June 2021

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Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression.
Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek

Int J Mol Sci· February 2021

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Impaired Brain Energy Metabolism: Involvement in Depression and Hypothyroidism.
Katarzyna Głombik, Jan Detka, Anna Kurek, Bogusława Budziszewska

Front Neurosci· December 2020

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Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes.
Katarzyna Głombik, Jan Detka, Joanna Góralska, Anna Kurek, Bogdan Solnica

Neurotox Res· February 2020

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Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line.
Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus

Pharmacol Rep· April 2019

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The reduced level of growth factors in an animal model of depression is accompanied by regulated necrosis in the frontal cortex but not in the hippocampus.
Mateusz Kucharczyk, Anna Kurek, Bartosz Pomierny, Jan Detka, Mariusz Papp

Psychoneuroendocrinology· August 2018

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Regulators of glucocorticoid receptor function in an animal model of depression and obesity.
Anna Kurek, Katarzyna Głombik, Jan Detka, Agnieszka Basta-Kaim, Marta Kubera

J Neuroendocrinol· March 2018

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The effects of pessimism on cell-mediated immunity in rats.
Katarzyna Curzytek, Marta Kubera, Ewa Trojan, Kinga Wójcik, Agnieszka Basta-Kaim, Jan Detka

Prog Neuropsychopharmacol Biol Psychiatry· January 2018

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Suppression of pro-inflammatory cytokine expression and lack of anti-depressant-like effect of fluoxetine in lipopolysaccharide-treated old female mice.
Weronika Duda, Marta Kubera, Grzegorz Kreiner, Katarzyna Curzytek, Jan Detka

Int Immunopharmacol· July 2017

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Pro-apoptotic Action of Corticosterone in Hippocampal Organotypic Cultures.
Anna Kurek, Mateusz Kucharczyk, Jan Detka, Joanna Ślusarczyk, Ewa Trojan

Neurotox Res· August 2016

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Chronic mild stress influences nerve growth factor through a matrix metalloproteinase-dependent mechanism.
Mateusz Kucharczyk, Anna Kurek, Jan Detka, Joanna Slusarczyk, Mariusz Papp

Psychoneuroendocrinology· April 2016

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Elevated brain glucose and glycogen concentrations in an animal model of depression.
Jan Detka, Anna Kurek, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń

Neuroendocrinology· October 2015

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Neuroendocrine link between stress, depression and diabetes.
Jan Detka, Anna Kurek, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń

Pharmacol Rep· October 2014

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The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain.
Joanna Miszkiel, Jan Detka, Joanna Cholewa, Małgorzata Frankowska, Ewa Nowak

Pharmacol Rep· August 2014

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Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction.
Marta Kubera, Katarzyna Curzytek, Monika Majewska-Szczepanik, Marian Szczepanik, Katarzyna Marcińska, Jan Detka

Pharmacol Rep· January 2013

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