Publications by authors named "Jan Dobert"

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Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.
Denise Balta, Anish Varghese, Susy Prieto Huarcaya, Alessandro Di Spiezio, André R A Marques, Jan Philipp Dobert

Mol Neurodegener· August 2025

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Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2.
Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, Priyadarshini Ravindran, Dustin J E Huard

Nat Commun· March 2025

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Activation and Purification of ß-Glucocerebrosidase by Exploiting its Transporter LIMP-2 - Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease.
Jan Philipp Dobert, Simon Bub, Rebecca Mächtel, Dovile Januliene, Lisa Steger

Adv Sci (Weinh)· July 2024

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From Lysosomal Storage Disorders to Parkinson's Disease - Challenges and Opportunities.
Rebecca Mächtel, Fanni Annamária Boros, Jan Philipp Dobert, Philipp Arnold, Friederike Zunke

J Mol Biol· June 2023

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Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.
Alice Drobny, Fanni Annamária Boros, Denise Balta, Susy Prieto Huarcaya, Deniz Caylioglu, Jan Philipp Dobert

Transl Neurodegener· June 2023

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Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) is localized in lysosomes and mediates resistance against kinase inhibitors.
Bastian Haberkorn, Stefan Oswald, Niklas Kehl, Arne Gessner, R Verena Taudte, Jan Philipp Dobert

Mol Pharmacol· September 2022

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The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches.
Alice Drobny, Susy Prieto Huarcaya, Jan Dobert, Annika Kluge, Josina Bunk

Biochim Biophys Acta Mol Cell Res· July 2022

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Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Susy Prieto Huarcaya, Alice Drobny, André R A Marques, Alessandro Di Spiezio, Jan Philipp Dobert

Autophagy· May 2022

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Corrigendum: Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties.
Josina Bunk, Susy Prieto Huarcaya, Alice Drobny, Jan Philipp Dobert, Lina Walther

Front Cell Dev Biol· June 2021

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Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties.
Josina Bunk, Susy Prieto Huarcaya, Alice Drobny, Jan Philipp Dobert, Lina Walther

Front Cell Dev Biol· February 2021

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Functional Characterization of Colon-Cancer-Associated Variants in Affecting the Catalytic Domain.
Jan Philipp Dobert, Anne-Sophie Cabron, Philipp Arnold, Egor Pavlenko, Stefan Rose-John

Biomedicines· October 2020

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Functional Characterization of Colon Cancer-Associated Mutations in : Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Egor Pavlenko, Anne-Sophie Cabron, Philipp Arnold, Jan Philipp Dobert, Stefan Rose-John

Int J Mol Sci· May 2019

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Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Anne-Sophie Cabron, Karim El Azzouzi, Melanie Boss, Philipp Arnold, Jeanette Schwarz, Jan Philipp Dobert

J Immunol· November 2018

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