Publications by authors named "Jan Dusek"

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Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation.
Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Jan Dusek

J Med Chem· July 2025

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Dexamethasone Acetate-Loaded PLGA Nanospheres Targeting Liver Macrophages.
Barbora Boltnarova, Anna Durinova, Lenka Jandova, Stanislav Micuda, Otto Kucera, Jan Dusek

Macromol Biosci· February 2025

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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky

Nat Commun· February 2025

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Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol.
Azam Rashidian, Jan Dušek, Martin Drastik, Lucie Smutná, Kristin Fritsche

Environ Sci Technol· April 2024

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Comparison of HepaRG and HepG2 cell lines to model mitochondrial respiratory adaptations in non‑alcoholic fatty liver disease.
Tumisang Edward Maseko, Moustafa Elkalaf, Eva Peterová, Halka Lotková, Pavla Staňková

Int J Mol Med· February 2024

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Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway.
Galina Karabanovich, Viktória Fabiánová, Anthony Vocat, Jan Dušek, Lenka Valášková

J Med Chem· January 2024

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2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR).
Zuzana Rania Brožová, Jan Dušek, Norbert Palša, Jana Maixnerová, Rajamanikkam Kamaraj

Eur J Med Chem· November 2023

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Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis.
Hana Lastuvkova, Zuzana Nova, Milos Hroch, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Jan Dusek

Toxicol Sci· November 2023

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Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-]pyridine Structure.
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda

J Med Chem· February 2023

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Real-time monitoring of Metridia luciferase release from cells upon interaction with model toxic substances by a fully automatic flow setup - A proof of concept.
Maite V Aguinaga Martínez, Natali Jozičová, Jan Dušek, Burkhard Horstkotte, Petr Pávek

Talanta· August 2022

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Gene Expression Profiling of 1α,25(OH) D Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes.
Petr Pavek, Jan Dusek, Tomas Smutny, Lukas Lochman, Radim Kucera

Mol Nutr Food Res· May 2022

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Measurement-Based Domain Parameter Optimization in Electrical Impedance Tomography Imaging.
Jan Dusek, Jan Mikulka

Sensors (Basel)· April 2021

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Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.
Josef Skoda, Jan Dusek, Martin Drastik, Alzbeta Stefela, Klara Dohnalova

Cells· November 2020

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The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids.
Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova

Acta Pharm Sin B· January 2020

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Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.
Jan Dusek, Josef Skoda, Ondrej Holas, Alzbeta Horvatova, Tomas Smutny

Toxicol Lett· October 2019

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Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
Galina Karabanovich, Jan Dušek, Karin Savková, Oto Pavliš, Ivona Pávková

J Med Chem· September 2019

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Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.
Lucie Hyrsova, Alena Vanduchova, Jan Dusek, Tomas Smutny, Alejandro Carazo

Toxicol Lett· January 2019

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Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.
Alejandro Carazo, Jan Dusek, Ondrej Holas, Josef Skoda, Lucie Hyrsova

Front Pharmacol· October 2018

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Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models.
Gabriela Dovrtelova, Ondrej Zendulka, Kristyna Noskova, Jan Jurica, Ondrej Pes, Jan Dusek

Drug Metab Dispos· June 2018

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Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.
Jan Dusek, Alejandro Carazo, Frantisek Trejtnar, Lucie Hyrsova, Ondřej Holas

Food Chem Toxicol· November 2017

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Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine.
Radek Jorda, Jan Dušek, Eva Řezníčková, Karel Pauk, Pratibha P Magar

Eur J Med Chem· July 2017

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Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.
Alejandro Carazo, Lucie Hyrsova, Jan Dusek, Hana Chodounska, Alzbeta Horvatova

Toxicol Lett· January 2017

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Synthesis of novel amphiphilic hyaluronan containing-aromatic fatty acids for fabrication of polymeric micelles.
Alena Matelová, Gloria Huerta-Angeles, Daniela Šmejkalová, Zdislava Brůnová, Jan Dušek

Carbohydr Polym· October 2016

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Optical and Magneto-Optical Properties of GdFe Thin Films in the Photon Energy Range From 1.5 to 5.5 eV.
Eva Jesenská, Takahiro Hashinaka, Takayuki Ishibashi, Lukáš Beran, Ján Dušek

Materials (Basel)· January 2016

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Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.
Aleš Imramovský, Radek Jorda, Karel Pauk, Eva Rezníčková, Jan Dušek

Eur J Med Chem· October 2013

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