Publications by authors named "Jan Ehses"

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Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1.
Dominika Nackiewicz, Meixia Dan, Madeleine Speck, Samuel Z Chow, Yi-Chun Chen, Jan A Ehses

iScience· January 2020

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Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control.
Louise Lang Lehrskov, Mark Preben Lyngbaek, Line Soederlund, Grit Elster Legaard, Jan Adam Ehses

Cell Metab· June 2018

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IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.
Aleksandar Ivovic, Andrei I Oprescu, Khajag Koulajian, Yusaku Mori, Judith A Eversley, Jan Ehses

Diabetologia· October 2017

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Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.
Clara Westwell-Roper, Heather C Denroche, Jan A Ehses, C Bruce Verchere

J Biol Chem· April 2016

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Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.
Eyler N Ngoh, Shelley B Weisser, Young Lo, Lisa K Kozicky, Roger Jen, Jan A Ehses

Gastroenterology· February 2016

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IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.
Clara Y Westwell-Roper, Cyrus A Chehroudi, Heather C Denroche, Jaques A Courtade, Jan A Ehses

Diabetologia· March 2015

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Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes.
Jan A Ehses, Marc Y Donath

Diabetologia· March 2015

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Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.
Sophie Calderari, Jean-Claude Irminger, Marie-Hélène Giroix, Jan A Ehses, Marie-Noëlle Gangnerau

PLoS One· October 2014

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Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Samuel Z Chow, Madeleine Speck, Piriya Yoganathan, Dominika Nackiewicz, Ann Maria Hansen, Jan A Ehses

Diabetes· September 2014

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TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6.
Dominika Nackiewicz, Meixia Dan, Wei He, Rosa Kim, Anisa Salmi, Jan A Ehses

Diabetologia· August 2014

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Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.
Clara Y Westwell-Roper, Jan A Ehses, C Bruce Verchere

Diabetes· May 2014

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Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.
Clara Westwell-Roper, Dominika Nackiewicz, Meixia Dan, Jan A Ehses

Immunol Cell Biol· April 2014

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Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?
Clara Westwell-Roper, Jan A Ehses

Diabetologia· March 2014

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Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.
Jonathan M Han, Scott J Patterson, Madeleine Speck, Jan A Ehses, Megan K Levings

J Immunol· January 2014

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Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation.
Christine Tang, Anthony E Naassan, Astrid Chamson-Reig, Khajag Koulajian, Tracy T Goh, Jan A Ehses

Endocrinology· January 2013

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
Helga Ellingsgaard, Irina Hauselmann, Beat Schuler, Abdella M Habib, Laurie L Baggio, Jan A Ehses

Nat Med· October 2011

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IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.
Clara Westwell-Roper, Derek L Dai, Galina Soukhatcheva, Kathryn J Potter, Nico van Rooijen, Jan A Ehses

J Immunol· September 2011

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Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes.
Christophe Noll, Gregory Lacraz, Jan Ehses, Josiane Coulaud, Danièle Bailbe

Biochim Biophys Acta· June 2011

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Cytokine production by islets in health and diabetes: cellular origin, regulation and function.
Marc Y Donath, Marianne Böni-Schnetzler, Helga Ellingsgaard, Philippe A Halban, Jan A Ehses

Trends Endocrinol Metab· May 2010

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Hippocampal neurovascular and hypothalamic-pituitary-adrenal axis alterations in spontaneously type 2 diabetic GK rats.
Juan Beauquis, Françoise Homo-Delarche, Marie-Hélène Giroix, Jan Ehses, Josiane Coulaud

Exp Neurol· March 2010

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Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.
Marianne Böni-Schnetzler, Simone Boller, Sarah Debray, Karim Bouzakri, Daniel T Meier, Jan A Ehses

Endocrinology· December 2009

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Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.
Marc Y Donath, Marianne Böni-Schnetzler, Helga Ellingsgaard, Jan A Ehses

Physiology (Bethesda)· December 2009

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Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells.
Sabine Rütti, Jan A Ehses, Rahel A Sibler, Richard Prazak, Lucia Rohrer

Endocrinology· October 2009

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Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.
Jan A Ehses, Helga Ellingsgaard, Marianne Böni-Schnetzler, Marc Y Donath

Arch Physiol Biochem· October 2009

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Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
Grégory Lacraz, Marie-Hélène Giroix, Nadim Kassis, Josiane Coulaud, Anne Galinier, Jan A Ehses

PLoS One· September 2009

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