Publications by authors named "Jan Eickhoff"

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Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors.
Srinivasulu Cherukupalli, Jan Eickhoff, Carsten Degenhart, Peter Habenberger, Anke Unger

Molecules· June 2025

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Design and Synthesis of Pyridine-Based Pyrrolo[2,3-]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach.
Srinivasulu Cherukupalli, Carsten Degenhart, Peter Habenberger, Anke Unger, Jan Eickhoff

Pharmaceuticals (Basel)· May 2025

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Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ.
Blaž Andlovic, Alexander Wolf, Malgorzata Hiltmann, Bert M Klebl, Jan Eickhoff

SLAS Discov· December 2024

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Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction.
Blaž Andlovic, Dario Valenti, Federica Centorrino, Francesca Picarazzi, Stanimira Hristeva, Jan Eickhoff

Biochemistry· September 2024

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Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland.
Frithjof Bjørnstad, Simen Havik, Thomas Ihle Aarhus, Iktedar Mahdi, Anke Unger, Jan Eickhoff

Eur J Med Chem· February 2024

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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
DongHoon Yu, Sabrina Wagner, Martin Schütz, Yeejin Jeon, Mooyoung Seo, Jan Eickhoff

Pharmaceutics· January 2024

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ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis.
Zülal Cibir, Jacqueline Hassel, Justin Sonneck, Lennart Kowitz, Alexander Beer, Jan Eike Eickhoff

Nat Commun· December 2023

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Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers.
Markus Wild, Dubravka Karner, Jan Eickhoff, Sabrina Wagner, Jintawee Kicuntod

Pharmaceutics· November 2023

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Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff

Virus Res· October 2023

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A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation.
Thomas Ihle Aarhus, Jan Eickhoff, Bert Klebl, Anke Unger, Joanna Boros

Eur J Med Chem· July 2023

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IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Blaž Andlovic, Geronimo Heilmann, Sabrina Ninck, Sebastian A Andrei, Federica Centorrino, Jan Eickhoff

Cell Chem Biol· June 2023

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Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Isolate.
Leonie Sagurna, Sascha Heinrich, Lara-Sophie Kaufmann, Christian Rückert-Reed, Tobias Busche, Jan Eickhoff

Antibiotics (Basel)· June 2023

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Synthesis and Development of Highly Selective Pyrrolo[2,3-]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Thomas Ihle Aarhus, Frithjof Bjørnstad, Camilla Wolowczyk, Kristin Uhlving Larsen, Line Rognstad, Jan Eickhoff

J Med Chem· May 2023

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Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target.
Julia Tillmanns, Sigrun Häge, Eva Maria Borst, Julia Wardin, Jan Eickhoff

Cells· April 2023

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A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling.
Johanna B Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Jan E Eickhoff

J Biol Chem· December 2022

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A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening.
Johanna Kaufmann, Nina Kathleen Blum, Falko Nagel, Anna Schuler, Julia Drube, Jan Eicke Eickhoff

Commun Biol· November 2022

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Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs).
Markus Wild, Jintawee Kicuntod, Lisa Seyler, Christina Wangen, Luca D Bertzbach, Jan Eickhoff

Int J Mol Sci· January 2021

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Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.
Lea Kremer, Elisabeth Hennes, Alexandra Brause, Andrei Ursu, Lucas Robke, Jan Eickhoff

Angew Chem Int Ed Engl· November 2019

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Kinase Chemodiversity from the Arctic: The Breitfussins.
Kine Ø Hansen, Jeanette H Andersen, Annette Bayer, Sunil K Pandey, Marianne Lorentzen, Jan Eickhoff

J Med Chem· November 2019

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Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo.
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Jan Eickhoff

Stem Cell Reports· March 2019

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In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model.
Eric Sonntag, Friedrich Hahn, Luca D Bertzbach, Lisa Seyler, Christina Wangen, Jan Eickhoff

Antiviral Res· January 2019

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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Jan Eickhoff

Sci Immunol· August 2018

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Modulators of 14-3-3 Protein-Protein Interactions.
Loes M Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Jan Eickhoff

J Med Chem· May 2018

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Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia.
Joachim R Göthert, Roze Imsak, Michael Möllmann, Stefanie Kesper, Maria Göbel, Jan Eickhoff

Oncotarget· May 2018

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Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.
Ulrich Lücking, Arne Scholz, Philip Lienau, Gerhard Siemeister, Dirk Kosemund, Jan Eickhoff

ChemMedChem· November 2017

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