Publications by authors named "Jan Kehler"

Claim this Profile
T
The Molecular Mechanism of PDE1 Regulation.
Jacob Nielsen, Morten Langgård, Josefine Fussing Tengberg, Jan Kehler

Cells· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Are the LSD-analogs lisuride and ergotamine examples of non-hallucinogenic serotonin 5-HT2A receptor agonists?
Jan Kehler, Morten Skøtt Thomsen Lindskov

J Psychopharmacol· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cross-pathway integration of cAMP signals through cGMP and calcium-regulated phosphodiesterases in mouse striatal cholinergic interneurons.
Ségolène Bompierre, Yelyzaveta Byelyayeva, Elia Mota, Marion Lefevre, Anna Pumo, Jan Kehler

Br J Pharmacol· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
Jessica Hayes, Bettina Laursen, Elin Eneberg, Jan Kehler, Lars Kyhn Rasmussen

Neuropharmacology· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2-furo[3,2-]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells.
Alejandro Castán, Ramón Badorrey, José A Díez, Claus T Christoffersen, Lars K Rasmussen, Jan Kehler

J Org Chem· May 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum.
Dahdjim B Betolngar, Élia Mota, Arne Fabritius, Jacob Nielsen, Charlotte Hougaard, Jan Kehler

Cereb Cortex· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
Jacob Krall, Francesco Bavo, Christina B Falk-Petersen, Claus H Jensen, Julie O Nielsen, Jan Kehler

J Med Chem· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.
Makhala Michell Khammy, Thomas Dalsgaard, Peter Hjørringgaard Larsen, Claus Tornby Christoffersen, Dorte Clausen, Jan Kehler

Br J Pharmacol· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.
Jacob Krall, Claus Hatt Jensen, Francesco Bavo, Christina Birkedahl Falk-Petersen, Anne Stæhr Haugaard, Jan Kehler

J Med Chem· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.
Morten Laursen, Lilliana Beck, Jan Kehler, Claus Tornby Christoffersen, Christoffer Bundgaard

Br J Pharmacol· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of -(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT Receptor Agonist.
Anders A Jensen, John D McCorvy, Sebastian Leth-Petersen, Christoffer Bundgaard, Gudrun Liebscher, Jan Kehler

J Pharmacol Exp Ther· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
5
5-HT/5-HT Receptor Pharmacology and Intrinsic Clearance of N-Benzylphenethylamines Modified at the Primary Site of Metabolism.
Sebastian Leth-Petersen, Ida N Petersen, Anders A Jensen, Christoffer Bundgaard, Mathias Bæk, Jan Kehler

ACS Chem Neurosci· November 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone.
Jacob Krall, Benjamin M Brygger, Sara B Sigurðardóttir, Clarissa K L Ng, Christoffer Bundgaard, Jan Kehler

ChemMedChem· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt

PLoS One· October 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.
Louise Thiesen, Jan Kehler, Rasmus P Clausen, Bente Frølund, Christoffer Bundgaard

J Pharmacol Exp Ther· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correlating the metabolic stability of psychedelic 5-HT₂A agonists with anecdotal reports of human oral bioavailability.
Sebastian Leth-Petersen, Christoffer Bundgaard, Martin Hansen, Martin A Carnerup, Jan Kehler

Neurochem Res· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain.
Jan Kehler, John Paul Kilburn, Sergio Estrada, Søren Rahn Christensen, Anders Wall

J Nucl Med· September 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors.
Antonio Dore, Battistina Asproni, Alessia Scampuddu, Gerard Aime Pinna, Claus Tornby Christoffersen, Jan Kehler

Eur J Med Chem· September 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.
Niels Krogsgaard-Larsen, Anders A Jensen, Tenna J Schrøder, Claus T Christoffersen, Jan Kehler

J Med Chem· July 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.
John Paul Kilburn, Jan Kehler, Morten Langgård, Mette N Erichsen, Sebastian Leth-Petersen

Bioorg Med Chem· October 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.
Stine B Vogensen, Aleš Marek, Tina Bay, Petrine Wellendorph, Jan Kehler

J Med Chem· October 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.
Jette G Petersen, Rikke Bergmann, Henriette A Møller, Charlotte G Jørgensen, Birgitte Nielsen, Jan Kehler

J Med Chem· February 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphodiesterase 10A inhibitors: a 2009 - 2012 patent update.
Jan Kehler

Expert Opin Ther Pat· January 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PDE10A inhibitors: novel therapeutic drugs for schizophrenia.
Jan Kehler, Jacob Nielsen

Curr Pharm Des· September 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.
Jan Kehler, Andreas Ritzen, Morten Langgård, Sebastian Leth Petersen, Mohamed M Farah

Bioorg Med Chem Lett· June 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis