Publications by authors named "Jan Koch"

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Compound Muscle Action Potential (CMAP) Amplitude Trajectories and Pattern in Adults with 5q-Spinal Muscular Atrophy Receiving Nusinersen Therapy: A Multicenter, Binational Observational Study.
Bogdan Bjelica, Camilla Wohnrade, Alma Osmanovic, Olivia Schreiber-Katz, Sonja Koerner, Jan C Koch

Eur J Neurol· November 2025

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Respiratory function in 192 adult patients with spinal muscular atrophy (SMA) treated with nusinersen - a multicenter observational study.
Claudia D Wurster, Benjamin Stolte, Tobias Kessler, Maren Freigang, Bogdan Bjelica, Jan C Koch

Orphanet J Rare Dis· September 2025

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Phenotypic intrafamilial variability of 5q-associated spinal muscular atrophy: A systematic multicentre sibling study.
Benedikt Becker, Isabell Cordts, Jutta Becker, Rene Günther, Matthias Baumann, Jan Christoph Koch

J Neuromuscul Dis· September 2025

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Fasudil attenuates disease spreading in ALS - a post-hoc analysis of the ROCK-ALS trial.
Andreas W Wolff, Andreas Leha, Jan C Koch, Antonia F Demleitner, Christoph Neuwirth

medRxiv· September 2025

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Self-assessment of amyotrophic lateral sclerosis functional rating scale on the patient's smartphone proves to be non-inferior to clinic data capture.
Laura Steinfurth, Torsten Grehl, Ute Weyen, Dagmar Kettemann, Robert Steinbach, Jan Christoph Koch

Amyotroph Lateral Scler Frontotemporal Degener· August 2025

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Retrograde axonal transport of autophagic vesicles and dynein-dynactin protein interaction are attenuated during aging in the rat optic nerve in vivo.
Xiaoyue Luo, Jiong Zhang, Johan Tolö, Sebastian Kügler, Uwe Michel, Jan Christoph Koch

Neural Regen Res· August 2025

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Analysis of Conformational Molecular Changes in Cerebrospinal Fluid Using Fourier Transform Infrared Spectroscopy in Neurodegenerative Diseases.
Tanja Dučić, Jan Christoph Koch

Methods Mol Biol· May 2025

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Long-Term Dynamics of CSF and Serum Neurofilament Light Chain in Adult Patients With 5q Spinal Muscular Atrophy Treated With Nusinersen.
Isabell Cordts, Cornelia Fuetterer, Annika Wachinger, Ricarda von Heynitz, Tobias Kessler, Jan Christoph Koch

Neurology· March 2025

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Provision, cough efficacy and treatment satisfaction of mechanical insufflation-exsufflation in a large multicenter cohort of patients with amyotrophic lateral sclerosis.
André Maier, Dagmar Kettemann, Ute Weyen, Torsten Grehl, Peter Caspar Schulte, Jan Christoph Koch, Birgit Koch

Sci Rep· March 2025

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T1-relaxation times along the corticospinal tract as a diagnostic marker in patients with amyotrophic lateral sclerosis.
Fiona Dierksen, Johanna S Geibel, Janika Albrecht, Sabine Hofer, Peter Dechent, Jan C Koch

Front Neuroimaging· February 2025

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[End of life perspectives: a systematic survey of patients with amyotrophic lateral sclerosis].
Clemens Eickhoff, Bettina Schöne-Seifert, Dagmar Kettemann, Eike Bormann, Torsten Grehl, Jan C Koch

Nervenarzt· December 2024

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Synthesis of phosphate stabilised iodanes and their application in intramolecular aryl migrations.
Jan Rick Koch, Mattis Damrath, Pim Puylaert, Boris J Nachtsheim

Chem Commun (Camb)· December 2024

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Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.
Jan C Koch, Andreas Leha, Helen Bidner, Isabell Cordts, Johannes Dorst

Lancet Neurol· November 2024

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Static transcranial magnetic stimulation does not alter cortical excitability in patients with amyotrophic lateral sclerosis on riluzole.
Caspar Stephani, Helena Krämer, Ivan Chakalov, Mathias Bähr, Walter Paulus, Jan Christoph Koch

Brain Stimul· October 2024

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Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: A longitudinal, multicenter study.
Thomas Meyer, Marie Dreger, Torsten Grehl, Ute Weyen, Dagmar Kettemann, Jan Christoph Koch

Eur J Neurol· September 2024

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Clinical and patient-reported outcomes and neurofilament response during tofersen treatment in SOD1-related ALS-A multicenter observational study over 18 months.
Thomas Meyer, Peggy Schumann, Patrick Weydt, Susanne Petri, Jochen H Weishaupt, Jan C Koch

Muscle Nerve· September 2024

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Patients' and caregivers' perception of multidimensional and palliative care in amyotrophic lateral sclerosis - protocol of a German multicentre study.
Katharina Linse, Constanze Weber, Peter Reilich, Florian Schöberl, Matthias Boentert, Jan Koch

Neurol Res Pract· July 2024

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Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients.
Jochen H Weishaupt, Péter Körtvélyessy, Peggy Schumann, Ivan Valkadinov, Ute Weyen, Jan C Koch

Commun Med (Lond)· July 2024

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5qSMA: standardised retrospective natural history assessment in 268 patients with four copies of SMN2.
Katharina Vill, Moritz Tacke, Anna König, Matthias Baumann, Manuela Baumgartner, Jan C Koch

J Neurol· May 2024

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Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration.
Xiaoyue Luo, Jiong Zhang, Johan Tolö, Sebastian Kügler, Uwe Michel, Jan Christoph Koch

Acta Neuropathol Commun· May 2024

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A Call for Gene Expression Analysis in Whole Blood of Patients With Rheumatoid Arthritis (RA) as a Biomarker for RA-Associated Interstitial Lung Disease.
Anna Wierczeiko, Matthias Linke, Johannes Peter Friedrich, Jan Koch, Andreas Schwarting

J Rheumatol· February 2024

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Economic evaluation of Motor Neuron Diseases: a nationwide cross-sectional analysis in Germany.
Felix Heinrich, Isabell Cordts, René Günther, Benjamin Stolte, Daniel Zeller, Jan Christoph Koch

J Neurol· October 2023

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Performance of serum neurofilament light chain in a wide spectrum of clinical courses of amyotrophic lateral sclerosis-a cross-sectional multicenter study.
Thomas Meyer, Erma Salkic, Torsten Grehl, Ute Weyen, Dagmar Kettemann, Jan Christoph Koch

Eur J Neurol· June 2023

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Spectrum and frequency of genetic variants in sporadic amyotrophic lateral sclerosis.
Wolfgang P Ruf, Matej Boros, Axel Freischmidt, David Brenner, Veselin Grozdanov, Jan C Koch

Brain Commun· May 2023

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Synchrotron-Based Fourier-Transform Infrared Micro-Spectroscopy of Cerebrospinal Fluid from Amyotrophic Lateral Sclerosis Patients Reveals a Unique Biomolecular Profile.
Tanja Dučić, Jan Christoph Koch

Cells· May 2023

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