Publications by authors named "Jan N M Commandeur"

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Exposure to cis- and trans-regioisomers of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-glutathione result in quantitatively and qualitatively different cellular effects in RPTEC/TERT1 cells.
Liliana Capinha, Paul Jennings, Jan N M Commandeur

Toxicol Lett· July 2023

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Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models.
Liliana Capinha, Yaran Zhang, Anna-Katharina Holzer, Anna-Katharina Ückert, Melinda Zana, Jan N M Commandeur

Arch Toxicol· February 2023

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Corrigendum to "Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment" [Toxicol. Lett. 341 (2021) 94-106].
Liliana Capinha, Paul Jennings, Jan N M Commandeur

Toxicol Lett· June 2021

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Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment.
Liliana Capinha, Paul Jennings, Jan N M Commandeur

Toxicol Lett· May 2021

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Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis.
Sandra Ortega Ugalde, Kerstin Wallraven, Alexander Speer, Wilbert Bitter, Tom N Grossmann, Jan N M Commandeur

Biochem Pharmacol· July 2020

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A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450-Catalyzed Substrate Conversion.
Rosa A Luirink, Marlies C A Verkade-Vreeker, Jan N M Commandeur, Daan P Geerke

Chembiochem· May 2020

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Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol.
Karla Frydenvang, Marlies C A Verkade-Vreeker, Floor Dohmen, Jan N M Commandeur, Maria Rafiq

PLoS One· January 2020

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Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to .
Sandra Ortega Ugalde, Dongping Ma, James J Cali, Jan N M Commandeur

SLAS Discov· August 2019

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Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Sandra Ortega Ugalde, Maikel Boot, Jan N M Commandeur, Paul Jennings, Wilbert Bitter

Appl Microbiol Biotechnol· May 2019

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Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole.
Stefan J Dekker, Floor Dohmen, Nico P E Vermeulen, Jan N M Commandeur

Br J Pharmacol· February 2019

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Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
Sandra Ortega Ugalde, Coen P de Koning, Kerstin Wallraven, Ben Bruyneel, Nico P E Vermeulen, Jan N M Commandeur

Appl Microbiol Biotechnol· November 2018

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Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals.
Shalenie P den Braver-Sewradj, Michiel W den Braver, Marc van Dijk, Yongjie Zhang, Stefan J Dekker, Jan N M Commandeur

Curr Drug Metab· October 2018

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High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions.
Yongjie Zhang, Lukas Wijaya, Stefan J Dekker, Nico P E Vermeulen, Jan N M Commandeur

J Pharm Biomed Anal· July 2018

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A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants.
Rosa A Luirink, Stefan J Dekker, Luigi Capoferri, Laura F H Janssen, Cynthia L Kuiper, Jan N M Commandeur

J Inorg Biochem· July 2018

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Glutathione -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.
Yongjie Zhang, Shalenie P den Braver-Sewradj, Michiel W den Braver, Steven Hiemstra, Nico P E Vermeulen, Jan N M Commandeur

Front Pharmacol· April 2018

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Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism.
Katarzyna E Lazarska, Stefan J Dekker, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· March 2018

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Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium.
Sandra Ortega Ugalde, Rosa A Luirink, Daan P Geerke, Nico P E Vermeulen, Wilbert Bitter, Jan N M Commandeur

J Inorg Biochem· March 2018

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Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.
Shalenie P den Braver-Sewradj, Michiel W den Braver, Robin M Toorneman, Stephanie van Leeuwen, Yongjie Zhang, Jan N M Commandeur

Chem Res Toxicol· February 2018

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Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors.
Shalenie P den Braver-Sewradj, Michiel W den Braver, Audrey Baze, Joachim Decorde, Massimiliano Fonsi, Jan N M Commandeur

Eur J Pharm Sci· November 2017

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Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.
Yongjie Zhang, Shalenie P den Braver-Sewradj, J Chris Vos, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· June 2017

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Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.
Yongjie Zhang, Nico P E Vermeulen, Jan N M Commandeur

Br J Clin Pharmacol· March 2017

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Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac.
Michiel W den Braver, Nico P E Vermeulen, Jan N M Commandeur

J Chromatogr B Analyt Technol Biomed Life Sci· March 2017

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Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.
Stefan J Dekker, Yongjie Zhang, J Chris Vos, Nico P E Vermeulen, Jan N M Commandeur

Chem Res Toxicol· December 2016

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Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.
Michiel W den Braver, Yongjie Zhang, Harini Venkataraman, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· July 2016

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Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.
Michiel W den Braver, Shalenie P den Braver-Sewradj, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· June 2016

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