Publications by authors named "Jan Stariat"

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Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: a case example of DpC, an anti-cancer drug that entered clinical trials.
Petra Reimerová, Ján Stariat, Hana Bavlovič Piskáčková, Hana Jansová, Jaroslav Roh

Anal Bioanal Chem· April 2019

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Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart.
Eduard Jirkovský, Anna Jirkovská, Jan Bureš, Jaroslav Chládek, Olga Lenčová, Ján Stariat

J Pharmacol Exp Ther· March 2018

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In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.
Eliška Potůčková, Jaroslav Roh, Miloslav Macháček, Sumit Sahni, Ján Stariat

PLoS One· July 2016

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Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.
Vit Sestak, Jan Stariat, Jolana Cermanova, Eliska Potuckova, Jaroslav Chladek

Oncotarget· December 2015

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LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).
Jan Bureš, Hana Jansová, Ján Stariat, Tomáš Filipský, Přemysl Mladěnka

J Pharm Biomed Anal· February 2015

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Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats.
Ján Stariat, Vlasta Suprunová, Jaroslav Roh, Vít Šesták, Tomáš Eisner

Biomed Chromatogr· May 2014

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Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium.
Petra Kovarikova, Ivana Pasakova-Vrbatova, Anna Vavrova, Jan Stariat, Jiri Klimes

J Pharm Biomed Anal· March 2013

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Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry.
Ján Stariat, Petra Kovaříková, Radim Kučera, Jiří Klimeš, Danuta S Kalinowski

Anal Bioanal Chem· February 2013

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LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.
Ján Stariat, Vít Sesták, Kateřina Vávrová, Milan Nobilis, Zuzana Kollárová

Anal Bioanal Chem· April 2012

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Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms.
Ivana Pasáková, Marcela Gladziszová, Jana Charvátová, Ján Stariat, Jiří Klimeš

J Sep Sci· June 2011

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Synthesis and initial in vitro evaluations of novel antioxidant aroylhydrazone iron chelators with increased stability against plasma hydrolysis.
Katerina Hruskova, Petra Kovarikova, Petra Bendova, Pavlina Haskova, Eliska Mackova, Jan Stariat

Chem Res Toxicol· March 2011

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Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.
Petra Kovaříková, Ján Stariat, Jiří Klimeš, Kateřina Hrušková, Kateřina Vávrová

J Chromatogr A· January 2011

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Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.
Ján Stariat, Petra Kovaříková, Jiří Klimeš, Danuta S Kalinowski, Des R Richardson

Anal Bioanal Chem· May 2010

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HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents.
Ján Stariat, Petra Kovaríková, Jirí Klimes, David B Lovejoy, Danuta S Kalinowski

J Chromatogr B Analyt Technol Biomed Life Sci· January 2009

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