Publications by authors named "Jan Theys"

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Dietary enrichment with n-3 lc-PUFA-rich fish oil improves preclinical outcome of radiotherapy and anti-PD-L1 combination treatment.
Annemarie J F Westheim, Ludwig J Dubois, Elia Prades-Sagarra, Jella G M van de Laak, Hester van Mourik, Jan Theys

Cancer Treat Res Commun· September 2025

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Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis.
Isabeau Vermeulen, Mengying Li, Hester van Mourik, Tulasi Yadati, Gert Eijkel, Jan Theys

FEBS J· April 2025

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Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Alexandra M Mowday, Jella M van de Laak, Zhe Fu, Kimiora L Henare, Ludwig Dubois, Jan Theys

Crit Rev Microbiol· November 2024

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Harnessing native-cryptic plasmids for stable overexpression of heterologous genes in Clostridium butyricum DSM 10702 for industrial and medical applications.
Yanchao Zhang, Ying Cong, Tom S Bailey, Ludwig J Dubois, Jan Theys

Microbiol Res· November 2024

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Targeted nutritional intervention attenuates experimental lung cancer cachexia.
Wouter R P H van de Worp, Jan Theys, Cecile J A Wolfs, Frank Verhaegen, Annemie M W J Schols

J Cachexia Sarcopenia Muscle· October 2024

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Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination.
Yanchao Zhang, Tom S Bailey, Philip Hittmeyer, Ludwig J Dubois, Jan Theys

Microb Cell Fact· April 2024

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Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery.
Jan Theys, Adam V Patterson, Alexandra M Mowday

Mol Diagn Ther· March 2024

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Development of a CRISPR-Cas12a system for efficient genome engineering in clostridia.
Yanchao Zhang, Aleksandra M Kubiak, Tom S Bailey, Luuk Claessen, Philip Hittmeyer, Jan Theys

Microbiol Spectr· December 2023

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A novel orthotopic mouse model replicates human lung cancer cachexia.
Wouter R P H van de Worp, Jan Theys, Alba Sanz González, Brent van der Heyden, Frank Verhaegen

J Cachexia Sarcopenia Muscle· June 2023

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Clostridia as live biotherapeutics: can modified species enhance disease treatments?
Alekandra M Kubiak, Jella van de Laak, Yanchao Zhang, Tom S Bailey, Luuk Claessen, Jan Theys

Future Microbiol· May 2023

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The Modulatory Effects of Fatty Acids on Cancer Progression.
Annemarie J F Westheim, Lara M Stoffels, Ludwig J Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Jan Theys

Biomedicines· January 2023

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Heterologous Gene Regulation in Clostridia: Rationally Designed Gene Regulation for Industrial and Medical Applications.
Yanchao Zhang, Tom S Bailey, Aleksandra M Kubiak, Philippe Lambin, Jan Theys

ACS Synth Biol· November 2022

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All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma.
Hester van Mourik, Mengying Li, Sabine Baumgartner, Jan Theys, Ronit Shiri-Sverdlov

Biomedicines· September 2022

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Homologous Recombination Deficiency Scar: Mutations and Beyond-Implications for Precision Oncology.
Alexander M A van der Wiel, Lesley Schuitmaker, Ying Cong, Jan Theys, Arne Van Hoeck

Cancers (Basel)· August 2022

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Fatty Acids as a Tool to Boost Cancer Immunotherapy Efficacy.
Annemarie J F Westheim, Lara M Stoffels, Ludwig J Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Jan Theys

Front Nutr· June 2022

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Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours.
Alexandra M Mowday, Ludwig J Dubois, Aleksandra M Kubiak, Jasmine V E Chan-Hyams, Christopher P Guise, Jan Theys

Cancer Gene Ther· February 2022

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Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.
Alexander M A van der Wiel, Victoria Jackson-Patel, Raymon Niemans, Ala Yaromina, Emily Liu, Jan Theys

Mol Cancer Ther· December 2021

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COVID-19 infection, progression, and vaccination: Focus on obesity and related metabolic disturbances.
Annemarie J F Westheim, Albert V Bitorina, Jan Theys, Ronit Shiri-Sverdlov

Obes Rev· October 2021

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Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice.
Tulasi Yadati, Tom Houben, Albert Bitorina, Yvonne Oligschlaeger, Marion J Gijbels, Jan Theys

Front Immunol· October 2021

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Deep Learning Based Automated Orthotopic Lung Tumor Segmentation in Whole-Body Mouse CT-Scans.
Wouter R P H van de Worp, Brent van der Heyden, Georgios Lappas, Ardy van Helvoort, Jan Theys

Cancers (Basel)· September 2021

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OxLDL as an Inducer of a Metabolic Shift in Cancer Cells.
Albert V Bitorina, Yvonne Oligschlaeger, Lingling Ding, Tulasi Yadati, Annemarie Westheim, Jan Theys

J Cancer· August 2021

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nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications.
Alexandra Marie Mowday, Janine Naomi Copp, Sophie Philippa Syddall, Ludwig Jerome Dubois, Jingli Wang, Jan Theys

Theranostics· June 2021

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Efficient Secretion of Murine IL-2 From an Attenuated Strain of , a Novel Delivery Vehicle for Cancer Immunotherapy.
Aleksandra M Kubiak, Tom S Bailey, Ludwig J Dubois, Jan Theys, Philippe Lambin

Front Microbiol· June 2021

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Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19-IL2 cures poorly immunogenic tumors when combined with radiotherapy.
Veronica Olivo Pimentel, Damiënne Marcus, Alexander Ma van der Wiel, Natasja G Lieuwes, Rianne Biemans, Jan Theys

J Immunother Cancer· March 2021

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Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models.
Wouter R P H van de Worp, Annemie M W J Schols, Jan Theys, Ardy van Helvoort, Ramon C J Langen

Front Nutr· December 2020

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