Publications by authors named "Jan de Backer"

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Lung Deposition of Tanimilast, an Inhaled Phosphodiesterase-4 Inhibitor, in Patients with Asthma or COPD, Evaluated Using Functional Respiratory Imaging.
Navid Monshi Tousi, Romina Osello, Debora Santoro, Laura Campochiaro, Jason H T Bates, Jan De Backer

J Aerosol Med Pulm Drug Deliv· November 2025

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In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging.
Dave Singh, Nicolas Roche, Libo Wu, Hosein Sadafi, Jan De Backer

Int J Chron Obstruct Pulmon Dis· July 2025

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Leveraging Model Master Files from a Technology Company Perspective: Facilitating Quantitative Medicine in Regulatory Frameworks.
Jan De Backer, James Clarke, Hosein Sadafi, William Ganley, Jessica Spires

Pharm Res· May 2025

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Regulatory and Industry Perspective on the Model Master File Framework for Locally Acting Drug Products.
Ross L Walenga, Khondoker Alam, James F Clarke, Jan De Backer, Markus Fridén

Pharm Res· May 2025

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Industry Perspectives on Implementation of Model Master File (MMF) Framework for Generics and Innovator Drugs: Opportunities, Challenges and Future Outlook.
Sivacharan Kollipara, Markus Friden, Tycho Heimbach, Pratik Saha, Jan De Backer

Pharm Res· May 2025

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Rapid deposition analysis of inhaled aerosols in human airways.
Hosein Sadafi, Wilfried De Backer, Gabriel Krestin, Jan De Backer

Sci Rep· October 2024

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Validation of computational fluid dynamics models for airway deposition with SPECT data of the same population.
Hosein Sadafi, Navid Monshi Tousi, Wilfried De Backer, Jan De Backer

Sci Rep· March 2024

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Personalized pulmonary rehabilitation program for patients with post-acute sequelae of COVID-19: A proof-of-concept retrospective study.
Wendel Dierckx, Wilfried De Backer, Yinka De Meyer, Eline Lauwers, Erik Franck, Jan De Backer

Physiol Rep· February 2024

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Use of the Same Model or Modeling Strategy Across Multiple Submissions: Focus on Complex Drug Products.
Ross L Walenga, Andrew H Babiskin, Sid Bhoopathy, James F Clarke, Jan De Backer

AAPS J· January 2024

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Towards the adoption of quantitative computed tomography in the management of interstitial lung disease.
Simon L F Walsh, Jan De Backer, Helmut Prosch, Georg Langs, Lucio Calandriello

Eur Respir Rev· January 2024

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Quantitative CT measures of pulmonary vascular volume distribution in pulmonary hypertension associated with COPD: Association with clinical characteristics and outcomes.
Hector R Cajigas, Ben Lavon, William Harmsen, Patrick Muchmore, Joana Costa, Jan De Backer

Pulm Circ· October 2023

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Modeled small airways lung deposition of two fixed-dose triple therapy combinations assessed with in silico functional respiratory imaging.
Omar Usmani, Grace Li, Jan De Backer, Hosein Sadafi, Libo Wu

Respir Res· September 2023

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Unraveling pathophysiologic mechanisms contributing to symptoms in patients with post-acute sequelae of COVID-19 (PASC): A retrospective study.
Wendel Dierckx, Wilfried De Backer, Kris Ides, Yinka De Meyer, Eline Lauwers, Jan De Backer

Physiol Rep· June 2023

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Precision Medicine for More Oxygen (P4O2)-Study Design and First Results of the Long COVID-19 Extension.
Nadia Baalbaki, Jelle M Blankestijn, Mahmoud I Abdel-Aziz, Jan de Backer, Somayeh Bazdar

J Pers Med· June 2023

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CT-derived measurements of pulmonary blood volume in small vessels and the need for supplemental oxygen in COVID-19 patients.
Wendel Dierckx, Wilfried De Backer, Muriel Lins, Yinka De Meyer, Kris Ides, Jan De Backer

J Appl Physiol (1985)· December 2022

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The effect of posture on airflow distribution, airway geometry and air velocity in healthy subjects.
Kris M Ides, Wilfried A De Backer, Maarten Lanclus, Glenn Leemans, Wendel Dierckx, Jan W De Backer

BMC Pulm Med· December 2022

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Pulmonary thromboembolic events in COVID-19-A systematic literature review.
Paul M Overton, Mark Toshner, Claire Mulligan, Pareen Vora, Sylvia Nikkho, Jan de Backer

Pulm Circ· July 2022

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Expiratory CT scanning in COVID-19 patients: can we add useful data?
Ruhana Dalla Costa, Matheus Zanon, Guilherme Watte, Stephan Philip Leonhardt Altmayer, Tan-Lucien Mohammed, Jan De Backer

J Bras Pneumol· April 2022

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Functional imaging improves patient selection for mandibular advancement device treatment outcome in sleep-disordered breathing: a prospective study.
Hélène Van Gaver, Sara Op de Beeck, Marijke Dieltjens, Jan De Backer, Johan Verbraecken, Wilfried A De Backer

J Clin Sleep Med· March 2022

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Lung deposition of inhaled once-daily long-acting muscarinic antagonists standard jet nebulizer or dry powder inhaler, measured using functional respiratory imaging, in patients with chronic obstructive pulmonary disease.
Glenn D Crater, Karmon Johnson, Jonathan Ward, Jan De Backer

Ther Adv Respir Dis· March 2022

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The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging.
Eline Lauwers, Dennis Belmans, Benjamin Mignot, Kris Ides, Kim Van Hoorenbeeck, Wilfried De Backer, Jan De Backer

Ther Adv Respir Dis· February 2022

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Association of abnormal pulmonary vasculature on CT scan for COVID-19 infection with decreased diffusion capacity in follow up: A retrospective cohort study.
Daniel Salerno, Ifeoma Oriaku, Melinda Darnell, Maarten Lanclus, Jan De Backer

PLoS One· November 2021

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Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study.
Eline Lauwers, Annemiek Snoeckx, Kris Ides, Kim Van Hoorenbeeck, Maarten Lanclus, Wilfried De Backer, Jan De Backer

BMC Pulm Med· August 2021

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Functional respiratory imaging assessment of budesonide/glycopyrrolate/formoterol fumarate and glycopyrrolate/formoterol fumarate metered dose inhalers in patients with COPD: the value of inhaled corticosteroids.
Maarten van den Berge, Jan De Backer, Cedric Van Holsbeke, Wilfried De Backer, Roopa Trivedi

Respir Res· July 2021

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Interstitial lung disease in systemic sclerosis quantification of disease classification and progression with high-resolution computed tomography: An observational study.
Johan Clukers, Maarten Lanclus, Dennis Belmans, Cedric Van Holsbeke, Wilfried De Backer, Jan De Backer

J Scleroderma Relat Disord· June 2021

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