Publications by authors named "Jan-Jacob Schuringa"

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Potent synergy of DHODH and SREBP inhibition in acute myeloid leukemia via disruption of cholesterol and lipid metabolism.
Shanna M Hogeling, Dominique Sternadt, Nikita La Rose, Marjan Geugien, Diego Pereira-Martins, Jan Jacob Schuringa

Haematologica· December 2025

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Validation of a Multiplex mRNA- and gDNA-Based Droplet Digital PCR Assay in Acute Myeloid Leukemia Patients with an NPM1 Mutation.
Albertus T J Wierenga, Lucy B Hesp, Arjan Simpelaar, Linde M Morsink, Carolien M Woolthuis, Jan Jacob Schuringa

Clin Chem· November 2025

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Metformin induces ferroptosis associated with lipidomic remodeling in AML.
Dominique Sternadt, Diego A Pereira-Martins, Prodromos Chatzikyriakou, Luise Albuquerque-Simões, Ming Yang, Jan Jacob Schuringa

Blood Adv· October 2025

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Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells.
Sander de Weerd, Xinyu Ma, Zahra Zohali, Lieve L Oudejans, Emmanouil Kyrloglou, Jan Jacob Schuringa

Adv Healthc Mater· July 2025

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High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability.
Diego A Pereira-Martins, Isabel Weinhäuser, Emmanuel Griessinger, Juan L Coelho-Silva, Douglas R Silveira, Jan Jacob Schuringa

Signal Transduct Target Ther· July 2025

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Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia.
Shanna M Hogeling, Duy Minh Lê, Nikita La Rose, Min Chul Kwon, Albertus T J Wierenga, Jan Jacob Schuringa

Haematologica· June 2025

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High expression of signal regulatory protein beta 2 marks a favourable prognostic AML subgroup and associates with increased sensitivity to phagocytosis.
Nienke Visser, Nisha K van der Meer, Yuan He, Gerwin Huls, Jan Jacob Schuringa

Immunol Res· June 2025

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K12-ligand-based CAR T cell therapy for CD7-positive T cell malignancies.
Nienke Visser, Macarena González-Corrales, Jimena Álvarez-Freile, Maurien G Pruis, Lena Rockstein, Jan Jacob Schuringa

Mol Ther Oncol· June 2025

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Lactate dehydrogenase A-coupled NAD regeneration is critical for acute myeloid leukemia cell survival.
Ayşegül Erdem, Séléna Kaye, Francesco Caligiore, Manuel Johanns, Fleur Leguay, Jan Jacob Schuringa

Cancer Metab· May 2025

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Elastic properties of leukemic cells linked to maturation stage and integrin activation.
Ceri J Richards, Albertus T J Wierenga, Annet Z Brouwers-Vos, Emmanouil Kyrloglou, Laura S Dillingh, Jan Jacob Schuringa

iScience· April 2025

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Corrigendum to "Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population, and particularly in men with prediabetes" [Atherosclerosis (2024) 395 117609].
Anouk G Groenen, Benedek Halmos, Isabelle A van Zeventer, Jonas B Salzbrunn, Marianne L Mayer, Jan Jacob Schuringa

Atherosclerosis· April 2025

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Lactate dehydrogenase A-coupled NAD regeneration is critical for acute myeloid leukemia cell survival.
Ayşegül Erdem, Séléna Kaye, Francesco Caligiore, Manuel Johanns, Fleur Leguay, Jan Jacob Schuringa

bioRxiv· March 2025

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Menin inhibitors in the treatment of acute myeloid leukemia.
Gerwin Huls, Carolien M Woolthuis, Jan Jacob Schuringa

Blood· February 2025

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Clonal hematopoiesis and myeloid skewing in older population-based individuals.
Maaike G J M van Bergen, Priscilla Kamphuis, Aniek O de Graaf, Jonas B Salzbrunn, Theresia N Koorenhof-Scheele, Jan Jacob Schuringa

Am J Hematol· December 2024

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Optimization of Cell Membrane Purification for the Preparation and Characterization of Cell Membrane Liposomes.
Sander de Weerd, Emma A Ruiter, Eleonora Calicchia, Giuseppe Portale, Jan Jacob Schuringa

Small Methods· December 2024

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Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation.
Vilma Dembitz, Hannah Lawson, Richard Burt, Sirisha Natani, Céline Philippe, Jan Jacob Schuringa

Leukemia· November 2024

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Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias.
Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Jan Jacob Schuringa

Blood· September 2024

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Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia.
Keli Lima, Frederico Lisboa Nogueira, Marcella Cipelli, Maria Fernanda Lopes Carvalho, Diego Antonio Pereira-Martins, Jan Jacob Schuringa

Eur J Pharmacol· August 2024

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Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population, and particularly in men with prediabetes.
Anouk G Groenen, Benedek Halmos, Isabelle A van Zeventer, Jonas B Salzbrunn, Marianne L Mayer, Jan Jacob Schuringa

Atherosclerosis· August 2024

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Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry.
Dimitrios Kleftogiannis, Sonia Gavasso, Benedicte Sjo Tislevoll, Nisha van der Meer, Inga K F Motzfeldt, Jan Jacob Schuringa

iScience· July 2024

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A 4-gene prognostic index for enhancing acute myeloid leukaemia survival prediction.
Cesar Alexander Ortiz Rojas, Diego Antonio Pereira-Martins, Candy Christie Bellido More, Dominique Sternadt, Isabel Weinhäuser, Jan Jacob Schuringa

Br J Haematol· June 2024

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Fluorescence lifetime imaging microscopy of flexible and rigid dyes probes the biophysical properties of synthetic and biological membranes.
Rafael B Lira, Laura S Dillingh, Jan-Jacob Schuringa, Gokhan Yahioglu, Klaus Suhling

Biophys J· June 2024

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VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses.
Yusheng Lin, Ghizlane Choukrani, Lena Dubbel, Lena Rockstein, Jimena Alvarez Freile, Jan Jacob Schuringa

Exp Hematol Oncol· March 2024

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Acute promyelocytic leukaemia in low-income and middle-income countries: a Brazilian experience.
Diego A Pereira-Martins, Isabel Weinhäuser, Juan L Coelho-Silva, Emanuele Ammatuna, Gerwin Huls, Jan Jacob Schuringa

Lancet Haematol· February 2024

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Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells.
Willemien F J Hof, Miranda Visser, Joyce J de Jong, Marian N Rajasekar, Jan Jacob Schuringa

Toxins (Basel)· January 2024

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