Publications by authors named "Jane M Withka"

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
Guoyun Bai, Thomas N O'Connell, Michael A Brodney, Christopher R Butler, Lara C Czabaniuk, Jane M Withka

ACS Med Chem Lett· October 2021

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
Ariamala Gopalsamy, Ann E Aulabaugh, Amey Barakat, Kevin C Beaumont, Shawn Cabral, Jane M Withka

J Med Chem· January 2021

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NMR spectroscopy: the swiss army knife of drug discovery.
Reto Horst, Kathleen A Farley, Bethany L Kormos, Jane M Withka

J Biomol NMR· November 2020

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Biophysical Interactions of Direct AMPK Activators.
Ravi G Kurumbail, Graham M West, Venkatasubramanian Dharmarajan, Kris A Borzilleri, Jane M Withka

Methods Mol Biol· January 2019

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Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
Mark E Schnute, Stephen E Benoit, Ingrid P Buchler, Nicole Caspers, Margaret L Grapperhaus, Jane M Withka

ACS Med Chem Lett· January 2019

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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Lily T-Y Cho, Aristos J Alexandrou, Rubben Torella, John Knafels, Jake Hobbs, Jane M Withka

Structure· April 2018

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
David J Edmonds, Daniel W Kung, Amit S Kalgutkar, Kevin J Filipski, David C Ebner, Jane M Withka

J Med Chem· March 2018

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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Kim Huard, Kay Ahn, Paul Amor, David A Beebe, Kris A Borzilleri, Jane M Withka

J Med Chem· September 2017

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Jane M Withka

J Med Chem· September 2016

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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Shenping Liu, Leslie A Dakin, Li Xing, Jane M Withka, Parag V Sahasrabudhe

Sci Rep· August 2016

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Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Shenping Liu, Joel Desharnais, Parag V Sahasrabudhe, Ping Jin, Wei Li, Jane M Withka

Sci Rep· May 2016

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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Francis Rajamohan, Allan R Reyes, Richard K Frisbie, Lise R Hoth, Parag Sahasrabudhe, Jane M Withka

Biochem J· March 2016

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Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
Huy N Hoang, Kun Song, Timothy A Hill, David R Derksen, David J Edmonds, Jane M Withka

J Med Chem· May 2015

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Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Matthew F Calabrese, Francis Rajamohan, Melissa S Harris, Nicole L Caspers, Rachelle Magyar, Jane M Withka

Structure· August 2014

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Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Christina I Schroeder, Joakim E Swedberg, Jane M Withka, K Johan Rosengren, Muharrem Akcan

Chem Biol· February 2014

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Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.
Ivan V Efremov, Felix F Vajdos, Kris A Borzilleri, Steven Capetta, Hou Chen, Jane M Withka

J Med Chem· November 2012

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Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
Michael A Brodney, Gabriela Barreiro, Kevin Ogilvie, Eva Hajos-Korcsok, John Murray, Jane M Withka

J Med Chem· November 2012

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Glycomimetic ligands for the human asialoglycoprotein receptor.
Sreeman K Mamidyala, Sanjay Dutta, Boris A Chrunyk, Cathy Préville, Hong Wang, Jane M Withka

J Am Chem Soc· February 2012

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Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.
Wan F Lau, Jane M Withka, David Hepworth, Thomas V Magee, Yuhua J Du

J Comput Aided Mol Des· July 2011

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Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists.
Lawrence A Reiter, Christopher S Jones, William H Brissette, Sandra P McCurdy, Yuriy A Abramov, Jane M Withka

Bioorg Med Chem Lett· May 2008

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Cyclization of N-terminal S-carbamoylmethylcysteine causing loss of 17 Da from peptides and extra peaks in peptide maps.
Kieran F Geoghegan, Lise R Hoth, Douglas H Tan, Kris A Borzilleri, Jane M Withka

J Proteome Res· April 2003

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Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold.
Estelle Dumez, John S Snaith, Richard F W Jackson, Andrew B McElroy, John Overington, Jane M Withka

J Org Chem· July 2002

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