Publications by authors named "Janel Lape"

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RHO1-2 meganuclease gene editing targets human P23H rhodopsin-induced retinitis pigmentosa to rejuvenate rods and maintain cones.
Archana Jalligampala, Jacob M Young, Jack Feist, Wei Wang, Francesca Barone, Janel Lape

bioRxiv· September 2025

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High-efficiency homology-directed insertion into the genome using the engineered homing endonuclease ARCUS.
Laura Christian Resly, Alan L Tubbs, Alexander J Vogel, Jo Ann Hux, Ian A MacDonald, Janel Lape

Nucleic Acids Res· September 2025

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Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.
Wendy K Shoop, Janel Lape, Megan Trum, Alea Powell, Emma Sevigny

Nat Metab· December 2023

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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Cassandra L Gorsuch, Paige Nemec, Mei Yu, Simin Xu, Dong Han, Janel Lape

Mol Ther· September 2022

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Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol.
Lili Wang, Jeff Smith, Camilo Breton, Peter Clark, Jia Zhang, Janel Lape

Nat Biotechnol· September 2018

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Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells.
Daniel T MacLeod, Jeyaraj Antony, Aaron J Martin, Rachel J Moser, Armin Hekele, Janel Lape

Mol Ther· April 2017

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Male-sterile maize plants produced by targeted mutagenesis of the cytochrome P450-like gene (MS26) using a re-designed I-CreI homing endonuclease.
Vesna Djukanovic, Jeff Smith, Keith Lowe, Meizhu Yang, Huirong Gao, Janel Lape

Plant J· December 2013

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Protein fabrication automation.
J Colin Cox, Janel Lape, Mahmood A Sayed, Homme W Hellinga

Protein Sci· March 2007

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