Publications by authors named "Janet Pinero"

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A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation.
Matthijs Vlasveld, Linda van den Berk, Janet Piñero, Palle S Helmke, Gerhard F Ecker

Arch Toxicol· November 2025

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Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.
Christopher E Goldring, Giusy Russomanno, Carmen Pin, Panuwat Trairatphisan, Kylie A Beattie

Nat Rev Drug Discov· October 2025

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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.
Eduardo Garcia, Lene Claudi, Maria Teresa La Chica Lhoëst, Anna Polishchuk, Valerie Samouillan, Janet Pinero

J Transl Med· May 2025

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proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation.
Paola Bermudez-Lekerika, Francesco Gualdi, Christine L Le Maitre, Janet Piñero, Baldomero Oliva

Comput Struct Biotechnol J· April 2025

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Nucleus pulposus cell network modelling in the intervertebral disc.
Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion, Christine Lyn Le Maitre, Janet Piñero

NPJ Syst Biol Appl· January 2025

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Predicting gene disease associations with knowledge graph embeddings for diseases with curtailed information.
Francesco Gualdi, Baldomero Oliva, Janet Piñero

NAR Genom Bioinform· June 2024

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Genopyc: a Python library for investigating the functional effects of genomic variants associated to complex diseases.
Francesco Gualdi, Baldomero Oliva, Janet Piñero

Bioinformatics· June 2024

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Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.
Anna Niarakis, Marek Ostaszewski, Alexander Mazein, Inna Kuperstein, Martina Kutmon

Front Immunol· February 2024

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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.
Louis Gall, Ferran Jardi, Lieve Lammens, Janet Piñero, Terezinha M Souza

CPT Pharmacometrics Syst Pharmacol· October 2023

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eTRANSAFE: data science to empower translational safety assessment.
Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Shoji Asakura

Nat Rev Drug Discov· August 2023

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Assessing network-based methods in the context of system toxicology.
Jordi Valls-Margarit, Janet Piñero, Barbara Füzi, Natacha Cerisier, Olivier Taboureau

Front Pharmacol· July 2023

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Visualization of automatically combined disease maps and pathway diagrams for rare diseases.
Piotr Gawron, David Hoksza, Janet Piñero, Maria Peña-Chilet, Marina Esteban-Medina

Front Bioinform· July 2023

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Genomic and proteomic biomarker landscape in clinical trials.
Janet Piñero, Pablo S Rodriguez Fraga, Jordi Valls-Margarit, Francesco Ronzano, Pablo Accuosto

Comput Struct Biotechnol J· March 2023

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Benchmarking post-GWAS analysis tools in major depression: Challenges and implications.
Judith Pérez-Granado, Janet Piñero, Laura I Furlong

Front Genet· October 2022

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Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression.
Judith Pérez-Granado, Janet Piñero, Alejandra Medina-Rivera, Laura I Furlong

Genes (Basel)· July 2022

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SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naïve-like and memory B-cell responses.
Leire de Campos-Mata, Sonia Tejedor Vaquero, Roser Tachó-Piñot, Janet Piñero, Emilie K Grasset

Clin Transl Immunology· September 2021

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The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research.
David Salgado, Irina M Armean, Michael Baudis, Sergi Beltran, Salvador Capella-Gutierrez

F1000Res· August 2021

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The DisGeNET cytoscape app: Exploring and visualizing disease genomics data.
Janet Piñero, Josep Saüch, Ferran Sanz, Laura I Furlong

Comput Struct Biotechnol J· May 2021

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Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice.
Ana Martín-Sánchez, Janet Piñero, Lara Nonell, Magdalena Arnal, Elena M Ribe

Alzheimers Res Ther· April 2021

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The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives.
François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu

Pharmaceuticals (Basel)· March 2021

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An ensemble learning approach for modeling the systems biology of drug-induced injury.
Joaquim Aguirre-Plans, Janet Piñero, Terezinha Souza, Giulia Callegaro, Steven J Kunnen

Biol Direct· January 2021

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The DisGeNET knowledge platform for disease genomics: 2019 update.
Janet Piñero, Juan Manuel Ramírez-Anguita, Josep Saüch-Pitarch, Francesco Ronzano, Emilio Centeno

Nucleic Acids Res· January 2020

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GUILDify v2.0: A Tool to Identify Molecular Networks Underlying Human Diseases, Their Comorbidities and Their Druggable Targets.
Joaquim Aguirre-Plans, Janet Piñero, Ferran Sanz, Laura I Furlong, Narcis Fernandez-Fuentes

J Mol Biol· June 2019

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ResMarkerDB: a database of biomarkers of response to antibody therapy in breast and colorectal cancer.
Judith Pérez-Granado, Janet Piñero, Laura I Furlong

Database (Oxford)· January 2019

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Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury.
Terezinha Souza, Panuwat Trairatphisan, Janet Piñero, Laura I Furlong, Julio Saez-Rodriguez

Front Genet· November 2018

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