Publications by authors named "Janet Tien"

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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis.
Gail D Lewis Phillips, Merry C Nishimura, Jennifer Arca Lacap, Samir Kharbanda, Elaine Mai, Janet Tien

Breast Cancer Res Treat· August 2017

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Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Yiyuan Yin, Stevan Djakovic, Scot Marsters, Janet Tien, Jing Peng

Mol Cancer Ther· October 2015

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MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer.
Xiangnan Du, Benjamin C Lin, Qian-Rena Wang, Hao Li, Ellen Ingalla, Janet Tien

Clin Cancer Res· December 2014

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Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.
Thomas H Pillow, Janet Tien, Kathryn L Parsons-Reponte, Sunil Bhakta, Hao Li

J Med Chem· October 2014

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Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer.
Ganapati V Hegde, Cecile C de la Cruz, Cecilia Chiu, Navneet Alag, Gabriele Schaefer, Janet Tien

Sci Transl Med· February 2013

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Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma.
Amrita V Kamath, Dan Lu, Priyanka Gupta, Denise Jin, Yan Xin, Janet Tien

Cancer Chemother Pharmacol· April 2012

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.
Ben-Quan Shen, Keyang Xu, Luna Liu, Helga Raab, Sunil Bhakta, Janet Tien

Nat Biotechnol· January 2012

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An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma.
Jyoti Asundi, Chae Reed, Jennifer Arca, Krista McCutcheon, Ronald Ferrando, Janet Tien

Clin Cancer Res· March 2011

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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
Jing Qing, Xiangnan Du, Yongmei Chen, Pamela Chan, Hao Li, Janet Tien

J Clin Invest· May 2009

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Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.
Klaus P Hoeflich, Sylvia Herter, Janet Tien, Leo Wong, Leanne Berry

Cancer Res· April 2009

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Michael Degtyarev, Ann De Mazière, Christine Orr, Jie Lin, Brian B Lee, Janet Y Tien

J Cell Biol· October 2008

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Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.
Yonglei Shang, Yifan Mao, Jennifer Batson, Suzie J Scales, Gail Phillips, Janet Tien

Mol Cancer Ther· September 2008

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Regulation of ERK3/MAPK6 expression by BRAF.
Klaus P Hoeflich, Michael T Eby, William F Forrest, Daniel C Gray, Janet Y Tien

Int J Oncol· October 2006

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Oncogenic BRAF is required for tumor growth and maintenance in melanoma models.
Klaus P Hoeflich, Daniel C Gray, Michael T Eby, Janet Y Tien, Leo Wong

Cancer Res· January 2006

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Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.
Janet Y L Tien, Andrew P Spicer

Dev Dyn· May 2005

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Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF.
Zongbing You, Grayson DuRaine, Janet Y L Tien, Corinne Lee, Timothy A Moseley

Biochem Biophys Res Commun· January 2005

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Hyaluronan and morphogenesis.
Andrew P Spicer, Janet Y L Tien

Birth Defects Res C Embryo Today· March 2004

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Investigation of hyaluronan function in the mouse through targeted mutagenesis.
Andrew P Spicer, Janet Lee Tien, Adriane Joo, Rodney A Bowling

Glycoconj J· January 2004

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