Publications by authors named "Janne T Backman"

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Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans.
Laura Aurinsalo, Outi Lapatto-Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Janne T Backman

Clin Pharmacol Ther· December 2025

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Early-career pre-congress meetings: investing in talent, transforming the future of clinical pharmacology.
Andrej Belančić, Kaisa Litonius, Noora Kulla, Robert Likić, Slobodan Janković, Janne T Backman

Eur J Clin Pharmacol· December 2025

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Toward a More accurate, Evidence-Based Classification of CYP Inhibitors: A Critical Appraisal of Current Systems.
Janne T Backman

Clin Pharmacol Ther· November 2025

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Clinical pharmacology consultations and their implementation in clinical decision making.
Mirjam Kauppila, Janne T Backman, Outi Lapatto-Reiniluoto

Br J Clin Pharmacol· November 2025

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A Phenotyping Tool for Seven Cytochrome P450 Enzymes and Two Transporters: Application to Examine the Effects of Clopidogrel and Gemfibrozil.
Laura Aurinsalo, Outi Lapatto-Reiniluoto, Mika Kurkela, Mikko Neuvonen, Johanna I Kiiski, Janne T Backman

Clin Pharmacol Ther· June 2025

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Identification of Genetic Variants Associated with Pravastatin and Pitavastatin Pharmacokinetics.
Anssi J H Mykkänen, E Katriina Tarkiainen, Suvi Taskinen, Mikko Neuvonen, Maria Paile-Hyvärinen, Janne T Backman

Clin Pharmacol Ther· June 2025

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Capillary Sampling Enables Venetoclax Concentration Measurement in Acute Myeloid Leukaemia Within Academic Multicentre Trial.
Sari Kytölä, Mika Kurkela, Johanna I Kiiski, Ida Vänttinen, Tanja Ruokoranta, Janne T Backman

Basic Clin Pharmacol Toxicol· June 2025

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In vitro assessment of inhibitory effects of kinase inhibitors on CYP2C9, 3A and 1A2: Prediction of drug-drug interaction risk with warfarin and direct oral anticoagulants.
Shasha Jin, Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Mikko Neuvonen, Janne T Backman

Eur J Pharm Sci· December 2024

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Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing.
Muhammad Waqar Ashraf, Satu Poikola, Mikko Neuvonen, Johanna I Kiiski, Vesa K Kontinen, Janne T Backman

Clin Pharmacokinet· November 2024

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Candesartan Has No Clinically Meaningful Effect on the Plasma Concentrations of Cytochrome P450 2C8 Substrate Repaglinide in Humans.
Mikael O W Piha, Kristiina Cajanus, Marica T Engström, Mikko Neuvonen, Troels K Bergmann, Janne T Backman

Drug Metab Dispos· November 2024

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Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes - detailed studies on CYP3A inhibitors.
Helinä Kahma, Marie-Noëlle Paludetto, Mikko Neuvonen, Mika Kurkela, Anne M Filppula, Janne T Backman

Eur J Pharm Sci· July 2024

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Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.
Anssi J H Mykkänen, E Katriina Tarkiainen, Suvi Taskinen, Mikko Neuvonen, Maria Paile-Hyvärinen, Janne T Backman

Clin Pharmacol Ther· June 2024

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Influence of Intravenous S-Ketamine on the Pharmacokinetics of Oral Morphine in Healthy Volunteers.
Terhi J Lohela, Satu Poikola, Daniel Backmansson, Outi Lapatto-Reiniluoto, Janne T Backman

Anesth Analg· March 2024

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The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study.
Piia Simonen, Lotta Ulander, Kari K Eklund, Mikko Niemi, Janne T Backman

Atheroscler Plus· March 2024

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Non-targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function.
Kreetta Hämäläinen, Päivi Hirvensalo, Mikko Neuvonen, Aleksi Tornio, Janne T Backman

Clin Transl Sci· March 2024

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Posaconazole-ibrutinib interaction cannot be avoided by staggered dosing: How to optimize ibrutinib dose during posaconazole treatment.
Aleksi M Olkkola, Tuija Tapaninen, Aleksi Tornio, Milka Hauta-Aho, Outi Lapatto-Reiniluoto, Janne T Backman

Br J Clin Pharmacol· February 2024

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Ticagrelor Increases Exposure to the Breast Cancer Resistance Protein Substrate Rosuvastatin.
Minna Lehtisalo, E Katriina Tarkiainen, Mikko Neuvonen, Mikko Holmberg, Johanna I Kiiski, Janne T Backman

Clin Pharmacol Ther· January 2024

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Drug-related deaths in a university hospital: Comparison to previous decades.
Mirjam Kauppila, Janne T Backman, Mikko Niemi, Outi Lapatto-Reiniluoto

Basic Clin Pharmacol Toxicol· January 2024

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Introduction of an electrochemical point-of-care assay for quantitative determination of paracetamol in finger-prick capillary whole blood samples.
Johanna Kujala, Niklas Wester, Terhi J Lohela, Mika Kurkela, Janne T Backman

Br J Clin Pharmacol· September 2023

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The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction.
Lotta Ulander, Piia Simonen, Heli Tolppanen, Otto Hartman, Tuomas T Rissanen, Janne T Backman

Atheroscler Plus· September 2023

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Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A .
Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Janne T Backman, Mikko Niemi

Drug Metab Dispos· March 2023

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A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics.
Minna Lehtisalo, Suvi Taskinen, E Katriina Tarkiainen, Mikko Neuvonen, Jenni Viinamäki, Janne T Backman

Br J Clin Pharmacol· January 2023

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Genomewide Association Study of Simvastatin Pharmacokinetics.
Anssi J H Mykkänen, Suvi Taskinen, Mikko Neuvonen, Maria Paile-Hyvärinen, E Katriina Tarkiainen, Janne T Backman

Clin Pharmacol Ther· September 2022

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Medicines, environment and clinical pharmacology.
Outi Lapatto-Reiniluoto, Mia Siven, Janne T Backman, Anneli Törrönen

Basic Clin Pharmacol Toxicol· August 2022

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Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine.
Kim J Blomqvist, Moritz O B Skogster, Mika J Kurkela, Marko P Rosenholm, Fredrik H G Ahlström, Janne T Backman

J Control Release· April 2022

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