Publications by authors named "Jared Churko"

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Modelling arrhythmogenic cardiomyopathy fattyfibro pathology with PKP2-deficient epicardial cells derived from human iPSCs.
Sadia L Falana, Sobhi G Kazmouz, Jessika B Iwanski, Sailu Sarvagalla, Blaire E Bas, Jared M Churko

Commun Biol· October 2025

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WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm.
Bao Q Thai, Stephanie A Luff, Jared M Churko, Jonathan N Young, Christopher M Sturgeon

bioRxiv· June 2025

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Integrated Multiomics Reveals Alterations in Paucimannose and Complex Type N-Glycans in Cardiac Tissue of Patients with COVID-19.
Sabarinath Peruvemba Subramanian, Melinda Wojtkiewicz, Fang Yu, Chase Castro, Erin N Schuette, Jared Churko

Mol Cell Proteomics· April 2025

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Atrial Fibrillation Related Titin Truncation Is Associated With Atrial Myopathy in Patient-Derived Induced Pluripotent Stem Cell Disease Models.
Kate Huang, Mishal Ashraf, Leili Rohani, Yinhan Luo, Ardin Sacayanan, Jared M Churko

Circ Genom Precis Med· February 2025

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Minimal Component, Protein-Free, and Cost-effective Human Pluripotent Stem Cell Cardiomyocyte Differentiation.
Jessika B Iwanski, Odunayo S Lawal, William T Kwon, Isabella Vazquez, Jared M Churko

Curr Protoc· February 2025

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Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction.
Jessika B Iwanski, Christopher T Pappas, Rachel M Mayfield, Gerrie P Farman, Rebecca Ahrens-Nicklas, Jared M Churko

NPJ Regen Med· September 2024

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Epicardial placement of human placental membrane protects from heart injury in a swine model of myocardial infarction.
Rinku S Skaria, Marissa A Lopez-Pier, Brij S Kathuria, Christian J Leber, Paul R Langlais, Jared M Churko

Physiol Rep· October 2023

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Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators.
Saptarshi Mallick, Jayati Chakrabarti, Jennifer Eschbacher, Andreas G Moraitis, Andrew E Greenstein, Jared Churko

Transl Res· June 2023

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Surfaceome mapping of primary human heart cells with CellSurfer uncovers cardiomyocyte surface protein LSMEM2 and proteome dynamics in failing hearts.
Linda Berg Luecke, Matthew Waas, Jack Littrell, Melinda Wojtkiewicz, Chase Castro, Jared M Churko

Nat Cardiovasc Res· January 2023

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Generation of an iPSC line from a Pontocerebellar Hypoplasia 1B patient harboring a homozygous c.395 A > C mutation in EXOSC3 along with a family matched control.
Ben N Stansfield, Sampath Rangasamy, Keri Ramsey, May Khanna, Jared M Churko

Stem Cell Res· December 2022

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Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing's Disease.
Jayati Chakrabarti, Ritu Pandey, Jared M Churko, Jennifer Eschbacher, Saptarshi Mallick

Cells· October 2022

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Tissue Engineering Techniques for Induced Pluripotent Stem Cell Derived Three-Dimensional Cardiac Constructs.
Tori Salem, Zachary Frankman, Jared M Churko

Tissue Eng Part B Rev· August 2022

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Neonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant.
Michaela Yuen, Lisa Worgan, Jessika Iwanski, Christopher T Pappas, Himanshu Joshi, Jared M Churko

Eur J Hum Genet· April 2022

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The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression.
Vadim Pivniouk, Oksana Pivniouk, Avery DeVries, Jennifer L Uhrlaub, Ashley Michael, Jared M Churko

J Allergy Clin Immunol· March 2022

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Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.
Jessika Iwanski, Sobhi G Kazmouz, Shuaizhi Li, Ben Stansfield, Tori T Salem, Jared M Churko

Stem Cell Reports· October 2021

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MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling.
Brandon Y H Chan, Andrej Roczkowsky, Woo Jung Cho, Mathieu Poirier, Consolato Sergi, Jared M Churko

Cardiovasc Res· January 2021

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Single-cell protein expression of hiPSC-derived cardiomyocytes using Single-Cell Westerns.
Eric Jabart, Josh Molho, Kristina Sin, Ben Stansfield, Sobhi G Kazmouz, Jared M Churko

J Mol Cell Cardiol· December 2020

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Human Autopsy-Derived Scalp Fibroblast Biobanking for Age-Related Neurodegenerative Disease Research.
Suet Theng Beh, Carlye Frisch, David A Brafman, Jared Churko, Jessica E Walker

Cells· October 2020

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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Jaecheol Lee, Vittavat Termglinchan, Sebastian Diecke, Ilanit Itzhaki, Chi Keung Lam, Jared M Churko

Nature· August 2019

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Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.
Jared M Churko, Priyanka Garg, Barbara Treutlein, Meenakshi Venkatasubramanian, Haodi Wu

Nat Commun· November 2018

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Linking Clinical Parameters and Genotype in Dilated Cardiomyopathy.
Jared M Churko

Circ Heart Fail· November 2018

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Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation.
Arun Sharma, Yuan Zhang, Jan W Buikema, Vahid Serpooshan, Orlando Chirikian, Jared M Churko

Sci Rep· April 2018

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SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation.
Jaecheol Lee, Ning-Yi Shao, David T Paik, Haodi Wu, Hongchao Guo, Jared M Churko

Cell Stem Cell· March 2018

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Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.
Jared M Churko, Jaecheol Lee, Mohamed Ameen, Mingxia Gu, Meenakshi Venkatasubramanian

Nat Biomed Eng· October 2017

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High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.
Arun Sharma, Paul W Burridge, Wesley L McKeithan, Ricardo Serrano, Praveen Shukla, Jared M Churko

Sci Transl Med· February 2017

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