Publications by authors named "Jashvant D Unadkat"

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Rosuvastatin PBPK Modeling: Incorporating Liver Concentrations and Effects of Ethnicity, Genetic Polymorphisms, Lactone Formation, DDI and Pregnancy.
Ankit Balhara, Robert H Weber, Jashvant D Unadkat

CPT Pharmacometrics Syst Pharmacol· August 2025

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Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms.
Yik Pui Tsang, Kai Wang, Edward J Kelly, Qingcheng Mao, Jashvant D Unadkat

bioRxiv· November 2025

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Effect of proinflammatory cytokines on intestinal drug transporters in human enteroid monolayers.
Kai Wang, Yik Pui Tsang, Kenneth E Thummel, Edward J Kelly, Qingcheng Mao, Jashvant D Unadkat

Drug Metab Dispos· November 2025

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Regulation of expression and activity of hepatic transporters by pregnancy-related hormones in HepaRG cells.
Sejal Sharma, Jashvant D Unadkat

Drug Metab Dispos· August 2025

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Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs.
Yang Li, Jocelyn Yabut, Zuo Zhang, Scott Fauty, Robert Houle, Jashvant D Unadkat

Drug Metab Dispos· July 2025

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Predicting in vivo cannabinoid-drug interactions mediated via inhibition of UDP-glucuronosyltransferases using in vitro studies and physiologically based pharmacokinetic modeling and simulations.
Sumit Bansal, Mary F Paine, Jashvant D Unadkat

Drug Metab Dispos· June 2025

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Identification of selective substrates and inhibitors of the major human renal uptake transporters.
Yik Pui Tsang, Acilegna G Rodriguez, Mark S Warren, Jashvant D Unadkat

Drug Metab Dispos· March 2025

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Cannabidiol and Δ9-tetrahydrocannabinol induce drug-metabolizing enzymes, but not transporters, in human hepatocytes: Implications for predicting complex cannabinoid-drug interactions.
Ankit Balhara, Yik Pui Tsang, Jashvant D Unadkat

Drug Metab Dispos· February 2025

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Quantification and prediction of human fetal (-)-Δ-tetrahydrocannabinol/(±)-11-OH-Δ-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity.
Aditya R Kumar, Lyndsey S Benson, Erica M Wymore, Jocelyn E Phipers, Jennifer C Dempsey, Jashvant D Unadkat

Nat Commun· January 2025

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Are Δ-Tetrahydrocannabinol and Its Major Metabolites Substrates or Inhibitors of Placental or Human Hepatic Drug Solute-Carrier Transporters?
Xin Chen, Zsuzsanna Gáborik, Qingcheng Mao, Jashvant D Unadkat

Int J Mol Sci· November 2024

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Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines.
Tianran Hao, Yik Pui Tsang, Mengyue Yin, Qingcheng Mao, Jashvant D Unadkat

J Pharmacol Exp Ther· September 2024

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The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes.
Jhohann Richard de Lima Benzi, Yik Pui Tsang, Jashvant D Unadkat

Front Pharmacol· August 2024

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Successful Prediction of Fetal Exposure to Dual BCRP/P-gp Drug Substrates Using the Efflux Ratio-Relative Expression Factor Approach and PBPK M&S.
Ankit Balhara, Mengyue Yin, Jashvant D Unadkat

Clin Pharmacol Ther· May 2024

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Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics-Informed Relative Expression Factor Approach.
Mengyue Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Zsuzsanna Gáborik, Jashvant D Unadkat

Clin Pharmacol Ther· March 2024

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Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells.
Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J Kelly, Jashvant D Unadkat

Pharmaceutics· February 2024

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Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model.
Flavia Storelli, Mayur K Ladumor, Xiaomin Liang, Yurong Lai, Paresh P Chothe, Jashvant D Unadkat

CPT Pharmacometrics Syst Pharmacol· January 2024

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Interpretation of Protein-Mediated Uptake of Statins by Hepatocytes Is Confounded by the Residual Statin-Protein Complex.
Mengyue Yin, Kazuya Ishida, Xiaomin Liang, Yurong Lai, Jashvant D Unadkat

Drug Metab Dispos· October 2023

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The Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis.
Jhohann Richard de Lima Benzi, Patrícia Pereira Dos Santos Melli, Geraldo Duarte, Jashvant D Unadkat, Vera Lucia Lanchote

Pharmaceutics· October 2023

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Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants.
Sumit Bansal, C Austin Zamarripa, Tory R Spindle, Elise M Weerts, Kenneth E Thummel, Jashvant D Unadkat

Clin Pharmacol Ther· September 2023

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Understanding the Mechanism and Extent of Transplacental Transfer of (-)-∆ -Tetrahydrocannabinol (THC) in the Perfused Human Placenta to Predict In Vivo Fetal THC Exposure.
Aditya R Kumar, Emily D Sheikh, Joshua W Monson, Sarah E Ligon, Rebecca L Talley, Jashvant D Unadkat

Clin Pharmacol Ther· August 2023

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A Physiologically-Based Pharmacokinetic Model for Cannabidiol in Healthy Adults, Hepatically-Impaired Adults, and Children.
Sumit Bansal, Mayur K Ladumor, Mary F Paine, Jashvant D Unadkat

Drug Metab Dispos· June 2023

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Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice.
Avinash K Persaud, Matthew C Bernier, Michael A Massey, Shipra Agrawal, Tejinder Kaur, Jashvant D Unadkat

Nat Commun· June 2023

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Author Correction: Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice.
Avinash K Persaud, Matthew C Bernier, Michael A Massey, Shipra Agrawal, Tejinder Kaur, Jashvant D Unadkat

Nat Commun· June 2023

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Predicting changes in the pharmacokinetics of CYP3A-metabolized drugs in hepatic impairment and insights into factors driving these changes.
Mayur K Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai, Osatohanmwen J Enogieru, Jashvant D Unadkat

CPT Pharmacometrics Syst Pharmacol· February 2023

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Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial.
C Austin Zamarripa, Tory R Spindle, Renuka Surujunarain, Elise M Weerts, Sumit Bansal, Jashvant D Unadkat

JAMA Netw Open· February 2023

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