Publications by authors named "Jason A Wiles"

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First-in-Class Clinically Investigated Oral Factor D Inhibitors for the Treatment of Complement-Mediated Diseases.
Venkat R Gadhachanda, Jason A Wiles, Steven D Podos, David Boyer, Jane Thanassi

Pharm Res· July 2025

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Correction: First-in-Class Clinically Investigated Oral Factor D Inhibitors for the Treatment of Complement-Mediated Diseases.
Venkat R Gadhachanda, Jason A Wiles, Steven D Podos, David Boyer, Jane Thanassi

Pharm Res· July 2025

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Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies.
David D Boyer, Ya-Ping Ko, Steven D Podos, Mark E Cartwright, Xiang Gao, Jason A Wiles

Transl Vis Sci Technol· October 2022

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Discovery and Development of the Oral Complement Factor D Inhibitor Danicopan (ACH-4471).
Jason A Wiles, Manuel D Galvan, Steven D Podos, Michael Geffner, Mingjun Huang

Curr Med Chem· September 2020

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Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity.
Venkat R Gadhachanda, Kyle J Eastman, Qiuping Wang, Avinash S Phadke, Dharaben Patel, Jason A Wiles

Bioorg Med Chem Lett· November 2018

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Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
Ha Young Kim, Jason A Wiles, Qiuping Wang, Godwin C G Pais, Edlaine Lucien

J Med Chem· May 2011

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Selenophene-containing inhibitors of type IIA bacterial topoisomerases.
Jason A Wiles, Avinash S Phadke, Barton J Bradbury, Michael J Pucci, Jane A Thanassi

J Med Chem· May 2011

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New quinolone antibiotics: a survey of the literature from 2005 to 2010.
Jason A Wiles, Barton J Bradbury, Michael J Pucci

Expert Opin Ther Pat· October 2010

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Small molecule inhibitors of E. coli primase, a novel bacterial target.
Atul Agarwal, Shirley Louise-May, Jane A Thanassi, Steven D Podos, Jijun Cheng, Jason A Wiles

Bioorg Med Chem Lett· May 2007

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Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
Qiuping Wang, Edlaine Lucien, Akihiro Hashimoto, Godwin C G Pais, David M Nelson, Jason A Wiles

J Med Chem· January 2007

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Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.
Jason A Wiles, Yongsheng Song, Qiuping Wang, Edlaine Lucien, Akihiro Hashimoto

Bioorg Med Chem Lett· March 2006

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Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.
Jason A Wiles, Qiuping Wang, Edlaine Lucien, Akihiro Hashimoto, Yongsheng Song

Bioorg Med Chem Lett· March 2006

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Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.
Jason A Wiles, Akihiro Hashimoto, Jane A Thanassi, Jijun Cheng, Christopher D Incarvito

J Med Chem· January 2006

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Kinetics of contact electrification between metals and polymers.
Bartosz A Grzybowski, Marcin Fialkowski, Jason A Wiles

J Phys Chem B· November 2005

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A tool for studying contact electrification in systems comprising metals and insulating polymers.
Jason A Wiles, Bartosz A Grzybowski, Adam Winkleman, George M Whitesides

Anal Chem· September 2003

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Electrostatic self-assembly of macroscopic crystals using contact electrification.
Bartosz A Grzybowski, Adam Winkleman, Jason A Wiles, Yisroel Brumer, George M Whitesides

Nat Mater· April 2003

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Dynamic self-assembly of rings of charged metallic spheres.
Bartosz A Grzybowski, Jason A Wiles, George M Whitesides

Phys Rev Lett· February 2003

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A Versatile and High-Yield Route to Active and Well-Defined Catalysts.
Jason A. Wiles, Steven H. Bergens, Koenraad P. M. Vanhessche, Daniel A. Dobbs, Valentin Rautenstrauch

Angew Chem Int Ed Engl· May 2001

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A Versatile and High-Yield Route to Active and Well-Defined Catalysts [Ru(bisphosphane)(H)(solvent) ](BF ).
Jason A Wiles, Steven H Bergens, Koenraad P M Vanhessche, Daniel A Dobbs, Valentin Rautenstrauch

Angew Chem Int Ed Engl· March 2001

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A Versatile and High-Yield Route to Active and Well-Defined Catalysts.
Jason A. Wiles, Steven H. Bergens, Koenraad P. M. Vanhessche, Daniel A. Dobbs, Valentin Rautenstrauch

Angew Chem Int Ed Engl· March 2001

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