Publications by authors named "Jason E Toombs"

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SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition.
Gilbert Z Murimwa, Natalie E Williams, Dina Alzhanova, Amir Mohammadi, Jill M Westcott, Jason E Toombs

Cancer Res· August 2025

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AXL-TBK1 driven AKT3 activation promotes metastasis.
Emily N Arner, Dina Alzhanova, Jill M Westcott, Stefan Hinz, Crina Elena Tiron, Jason E Toombs

Sci Signal· December 2024

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Development of betabodies: The next generation of phosphatidylserine targeting agents.
Natalie Z Phinney, Xianming Huang, Jason E Toombs, Rolf A Brekken

J Biol Chem· September 2024

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Pleiotrophin drives a prometastatic immune niche in breast cancer.
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Jason E Toombs

J Exp Med· May 2023

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Tumor Cells Modulate Macrophage Phenotype in a Novel In Vitro Co-Culture Model of the NSCLC Tumor Microenvironment.
Josiah Voth Park, Raghav Chandra, Ling Cai, Debolina Ganguly, Huiyu Li, Jason E Toombs

J Thorac Oncol· October 2022

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AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer.
Yuqing Zhang, Emily N Arner, Ali Rizvi, Jason E Toombs, Huocong Huang

Mol Cancer Ther· January 2022

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AXL Is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer.
Wenting Du, Natalie Z Phinney, Huocong Huang, Zhaoning Wang, Jill Westcott, Jason E Toombs

Mol Cancer Res· August 2021

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Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation.
Rahul Vijay, Jenna J Guthmiller, Alexandria J Sturtz, Sequoia Crooks, Jordan T Johnson, Jason E Toombs

J Exp Med· June 2021

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Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation.
Karoliina Stefanius, Kelly Servage, Marcela de Souza Santos, Hillery Fields Gray, Jason E Toombs

Elife· May 2019

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Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer.
Kathleen F Ludwig, Wenting Du, Noah B Sorrelle, Katarzyna Wnuk-Lipinska, Mary Topalovski, Jason E Toombs

Cancer Res· January 2018

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Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model.
Begoña Díaz, Katherine T Ostapoff, Jason E Toombs, Jason Lo, Michael Y Bonner

Oncotarget· August 2016

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Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1.
Tanvi J Desai, Jason E Toombs, John D Minna, Rolf A Brekken, Damith Gomika Udugamasooriya

Oncotarget· May 2016

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Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.
Miao Wang, Mary Topalovski, Jason E Toombs, Christopher M Wright, Zachary R Moore

Cancer Res· December 2015

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Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.
Amanda Kirane, Kathleen F Ludwig, Noah Sorrelle, Gry Haaland, Tone Sandal, Jason E Toombs

Cancer Res· September 2015

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Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.
Malia B Potts, Elizabeth A McMillan, Tracy I Rosales, Hyun Seok Kim, Yi-Hung Ou, Jason E Toombs

Nat Chem Biol· June 2015

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Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.
Kristina Y Aguilera, Lee B Rivera, Hoon Hur, Juliet G Carbon, Jason E Toombs

Cancer Res· February 2014

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Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.
Hyun Seok Kim, Saurabh Mendiratta, Jiyeon Kim, Chad Victor Pecot, Jill E Larsen, Jason E Toombs

Cell· October 2013

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Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.
David E Gerber, Puja Gupta, Michael T Dellinger, Jason E Toombs, Michael Peyton

Mol Cancer Ther· November 2012

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Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib.
Amanda Kirane, Jason E Toombs, Jill E Larsen, Katherine T Ostapoff, Kathryn R Meshaw

Carcinogenesis· September 2012

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Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.
Amanda Kirane, Jason E Toombs, Katherine Ostapoff, Juliet G Carbon, Sara Zaknoen

Clin Cancer Res· September 2012

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Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.
Shanna A Arnold, Lee B Rivera, Juliet G Carbon, Jason E Toombs, Chi-Lun Chang

PLoS One· July 2012

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Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer.
Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken

BMC Cancer· January 2011

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r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction.
Laura A Sullivan, Juliet G Carbon, Christina L Roland, Jason E Toombs, Mari Nyquist-Andersen

PLoS One· August 2010

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Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.
Sean P Dineen, Christina L Roland, Rachel Greer, Juliet G Carbon, Jason E Toombs

Cancer Res· April 2010

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Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts.
Christina L Roland, Sean P Dineen, Jason E Toombs, Juliet G Carbon, C Wayne Smith

Exp Biol Med (Maywood)· February 2010

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