Publications by authors named "Jason R Clapper"

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Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.
Jason R Clapper, Cassandra L Henry, Micah J Niphakis, Anna M Knize, Aundrea R Coppola

J Pharmacol Exp Ther· December 2018

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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.
Justin S Cisar, Olivia D Weber, Jason R Clapper, Jacqueline L Blankman, Cassandra L Henry

J Med Chem· October 2018

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Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment.
Jason R Clapper, Michelle D Hendricks, Guibao Gu, Carrie Wittmer, Carrie S Dolman

Am J Physiol Gastrointest Liver Physiol· October 2013

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Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models.
Jason R Clapper, Jennifer Athanacio, Carrie Wittmer, Pete S Griffin, Lawrence D'Souza

Eur J Pharmacol· January 2013

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2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism.
Kwang-Mook Jung, Jason R Clapper, Jin Fu, Giuseppe D'Agostino, Ana Guijarro

Cell Metab· March 2012

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Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.
Federica Vacondio, Claudia Silva, Alessio Lodola, Caterina Carmi, Silvia Rivara, Jason R Clapper

Eur J Med Chem· September 2011

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Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Jason R Clapper, Guillermo Moreno-Sanz, Roberto Russo, Ana Guijarro, Federica Vacondio

Nat Neurosci· October 2010

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A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Sarah A Eisenstein, Jason R Clapper, Philip V Holmes, Daniele Piomelli, Andrea G Hohmann

Pharmacol Res· May 2010

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Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.
Federica Vacondio, Claudia Silva, Alessio Lodola, Alessandro Fioni, Silvia Rivara, Jason R Clapper

ChemMedChem· September 2009

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A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo.
Jason R Clapper, Federica Vacondio, Alvin R King, Andrea Duranti, Andrea Tontini

ChemMedChem· September 2009

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The endocannabinoid system as a target for the treatment of cannabis dependence.
Jason R Clapper, Regina A Mangieri, Daniele Piomelli

Neuropharmacology· April 2009

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Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.
Zuzana Justinova, Regina A Mangieri, Marco Bortolato, Svetlana I Chefer, Alexey G Mukhin, Jason R Clapper

Biol Psychiatry· December 2008

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Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
Marco Mor, Alessio Lodola, Silvia Rivara, Federica Vacondio, Andrea Duranti, Jason R Clapper

J Med Chem· June 2008

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URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.
Alvin R King, Andrea Duranti, Andrea Tontini, Silvia Rivara, Anja Rosengarth, Jason R Clapper

Chem Biol· December 2007

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Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754).
Giorgio Tarzia, Francesca Antonietti, Andrea Duranti, Andrea Tontini, Marco Mor, Jason R Clapper

Ann Chim· September 2007

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The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues.
Jason R Clapper, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia

Pharmacol Res· November 2006

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