Publications by authors named "Jason Sheltzer"

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A clinical-stage oncology compound selectively targets drug-resistant cancers.
Kaitlin Long, Debanjan Bhattacharjee, Samuel H Newman-Stonebraker, Simon Suhr, Brandon Q Mercado, Jason M Sheltzer

bioRxiv· November 2025

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On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.
Linda Julian, Lisa Crozier, Devon Lukow, Sanat Mishra, Aditi Swamy, Jason M Sheltzer

bioRxiv· August 2025

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Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation.
Sophia N Lee, Erin C Banda, Lu Qiao, Sarah L Thompson, Karan Singh, Jason M Sheltzer

bioRxiv· August 2025

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Explainable Machine Learning Identifies Factors for Dosage Compensation in Aneuploid Human Cancer Cells.
Erik Marcel Heller, Karen Barthel, Markus Räschle, Klaske M Schukken, Jason M Sheltzer

bioRxiv· May 2025

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Paralog Co-Targeting Identifies Selective Genetic Redundancies across Cancer Types.
Gregory Gauthier-Coles, Jason M Sheltzer

Cancer Discov· December 2024

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An elevated rate of whole-genome duplications in cancers from Black patients.
Leanne M Brown, Ryan A Hagenson, Tilen Koklič, Iztok Urbančič, Lu Qiao, Jason M Sheltzer

Nat Commun· September 2024

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The next Nobel Prize in chemistry or in physiology or medicine.
Cigall Kadoch, Jason M Sheltzer, Hang Yin

Cell Chem Biol· September 2024

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Evolving copy number gains promote tumor expansion and bolster mutational diversification.
Zicheng Wang, Yunong Xia, Lauren Mills, Athanasios N Nikolakopoulos, Nicole Maeser, Jason M Sheltzer

Nat Commun· March 2024

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Aneuploidy in human cancer: new tools and perspectives.
Asad A Lakhani, Sarah L Thompson, Jason M Sheltzer

Trends Genet· December 2023

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Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor.
Debanjan Bhattacharjee, Jaweria Bakar, Surbhi P Chitnis, Erin L Sausville, Kumar Dilip Ashtekar, Jason M Sheltzer

Cell Chem Biol· October 2023

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Oncogene-like addiction to aneuploidy in human cancers.
Vishruth Girish, Asad A Lakhani, Sarah L Thompson, Christine M Scaduto, Leanne M Brown, Jason M Sheltzer

Science· August 2023

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Ricolinostat is not a highly selective HDAC6 inhibitor.
Guillaume Médard, Jason M Sheltzer

Nat Cancer· June 2023

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Oncogene-like addiction to aneuploidy in human cancers.
Vishruth Girish, Asad A Lakhani, Christine M Scaduto, Sarah L Thompson, Leanne M Brown, Jason M Sheltzer

bioRxiv· January 2023

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Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
Zhengnian Li, Ryosuke Ishida, Yan Liu, Jinhua Wang, Yina Li, Jason M Sheltzer

Eur J Med Chem· August 2022

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Extensive protein dosage compensation in aneuploid human cancers.
Klaske M Schukken, Jason M Sheltzer

Genome Res· July 2022

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Genome-wide identification and analysis of prognostic features in human cancers.
Joan C Smith, Jason M Sheltzer

Cell Rep· March 2022

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Chromosomal instability and aneuploidy as causes of cancer drug resistance.
Devon A Lukow, Jason M Sheltzer

Trends Cancer· January 2022

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Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding.
Arunava Ghosh, Vishruth Girish, Monet Lou Yuan, Raymond D Coakley, Joe A Wrennall, Jason M Sheltzer

Am J Respir Crit Care Med· January 2022

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Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer.
Wei-Chia Chen, Juannan Zhou, Jason M Sheltzer, Justin B Kinney, David M McCandlish

Proc Natl Acad Sci U S A· October 2021

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Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies.
Devon A Lukow, Erin L Sausville, Pavit Suri, Narendra Kumar Chunduri, Angela Wieland, Jason M Sheltzer

Dev Cell· September 2021

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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.
Markus Hoffmann, Heike Hofmann-Winkler, Joan C Smith, Nadine Krüger, Prerna Arora, Jason M Sheltzer

EBioMedicine· March 2021

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Aneuploidy as a promoter and suppressor of malignant growth.
Anand Vasudevan, Klaske M Schukken, Erin L Sausville, Vishruth Girish, Oluwadamilare A Adebambo, Jason M Sheltzer

Nat Rev Cancer· February 2021

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Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
John Michael Replogle, Wen Zhou, Adrianna E Amaro, James M McFarland, Mariana Villalobos-Ortiz, Jason Sheltzer

Proc Natl Acad Sci U S A· December 2020

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Angelika Amon (1967-2020).
Jason M Sheltzer, Rosella Visintin

Science· December 2020

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A CRISPR Competition Assay to Identify Cancer Genetic Dependencies.
Vishruth Girish, Jason M Sheltzer

Bio Protoc· July 2020

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