Publications by authors named "Jason Shirian"

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Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple-negative breast cancer cells.
Naama Rotenberg, Mark Feldman, Jason Shirian, Alexandra Hockla, Evette S Radisky

J Biol Chem· November 2024

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Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension.
Jason Shirian, Alexandra Hockla, Justyna J Gleba, Matt Coban, Naama Rotenberg

Biomolecules· September 2024

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Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension.
Jason Shirian, Alexandra Hockla, Justyna J Gleba, Matt Coban, Naama Rotenberg

bioRxiv· June 2024

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Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein-Protein Complexes.
Michael Heyne, Jason Shirian, Itay Cohen, Yoav Peleg, Evette S Radisky

J Am Chem Soc· October 2021

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Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.
Jason Shirian, Valeria Arkadash, Itay Cohen, Tamila Sapir, Evette S Radisky

FEBS Lett· April 2018

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Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution.
Valeria Arkadash, Gal Yosef, Jason Shirian, Itay Cohen, Yuval Horev

J Biol Chem· February 2017

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Cold Spots in Protein Binding.
Jason Shirian, Oz Sharabi, Julia M Shifman

Trends Biochem Sci· September 2016

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Combinatorial and Computational Approaches to Identify Interactions of Macrophage Colony-stimulating Factor (M-CSF) and Its Receptor c-FMS.
Lior Rosenfeld, Jason Shirian, Yuval Zur, Noam Levaot, Julia M Shifman

J Biol Chem· October 2015

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Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs.
Oz Sharabi, Jason Shirian, Moran Grossman, Mario Lebendiker, Irit Sagi

PLoS One· June 2015

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Mapping of the binding landscape for a picomolar protein-protein complex through computation and experiment.
Yonatan Aizner, Oz Sharabi, Jason Shirian, George R Dakwar, Marina Risman

Structure· April 2014

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Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces.
Oz Sharabi, Jason Shirian, Julia M Shifman

Biochem Soc Trans· October 2013

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