Publications by authors named "Jason Tchieu"

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Patient-Specific Midbrain Organoids with CRISPR Correction Reveal Disease Mechanisms and Enable Therapeutic Evaluation in Neuronopathic Gaucher Disease.
Yi Lin, Benjamin Liou, Venette Fannin, Stuart Adler, Christopher N Mayhew, Jason Tchieu

bioRxiv· November 2025

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ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis.
Xuyao Chang, Wenqi Li, Satoshi Matsui, Cindy Huynh, Craig Erickson, Jason Tchieu

Nat Commun· October 2025

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Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway.
Joshua Peter, Kaejaren C N Caldwell, Lucas McClain, Jason Tchieu, Ashley E Ross

Neurobiol Dis· September 2025

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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids.
Yifei Miao, Nicole M Pek, Cheng Tan, Cheng Jiang, Zhiyun Yu, Jason Tchieu

Cell· August 2025

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Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids.
Hongwei Cai, Chunhui Tian, Lei Chen, Yang Yang, Alfred Xuyang Sun, Jason Tchieu

Cell Stem Cell· May 2025

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Generation of Prefrontal Cortex Neurons from Human Pluripotent Stem Cells Under Chemically Defined Conditions.
Gustav Y Cederquist, Polina Oberst, Xuyao Chang, Jason Tchieu, Lorenz Studer

Methods Mol Biol· April 2025

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An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m A- mediated epi-transcriptomic dysregulation underlying synaptic dysfunction.
Lu Lu, Avijite Kumer Sarkar, Lan Dao, Yanchen Liu, Chunlong Ma, Jason Tchieu

bioRxiv· January 2025

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ZMYND11 Functions in Bimodal Regulation of Latent Genes and Brain-like Splicing to Safeguard Corticogenesis.
Xuyao Chang, Wenqi Li, Satoshi Matsui, Cindy Huynh, Gustav Y Cederquist, Jason Tchieu

bioRxiv· October 2024

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Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Jason Tchieu

Nat Commun· September 2024

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Vascular network-inspired diffusible scaffolds for engineering functional neural organoids.
Hongwei Cai, Chunhui Tian, Lei Chen, Kyle McCracken, Jason Tchieu

bioRxiv· September 2024

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Functional Neural Networks in Human Brain Organoids.
Longjun Gu, Hongwei Cai, Lei Chen, Mingxia Gu, Jason Tchieu

BME Front· September 2024

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Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration.
Xuezhao Liu, Dazhuan Eric Xin, Xiaowen Zhong, Chuntao Zhao, Zhidan Li, Jason Tchieu

Cell· May 2024

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Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids.
Yifei Miao, Cheng Tan, Nicole M Pek, Zhiyun Yu, Kentaro Iwasawa, Jason Tchieu

bioRxiv· February 2024

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Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy.
Homa Majd, Sadaf Amin, Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo Arroyo, Jason Tchieu

Cell Stem Cell· May 2023

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Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease.
Charlotte E Verrall, Shrujna Patel, Leksi Travitz, Jason Tchieu, Russel C Dale

Transl Pediatr· April 2023

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Brain Organoid Computing for Artificial Intelligence.
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Hongcheng Liu, Jason Tchieu

bioRxiv· March 2023

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Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders.
Xuyao Chang, Mingxia Gu, Jason Tchieu

Cells· January 2022

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Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.
Vidya Padmanabhan Nair, Hengyuan Liu, Gabriele Ciceri, Johannes Jungverdorben, Goar Frishman, Jason Tchieu

Cell Stem Cell· September 2021

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Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.
Vidya Padmanabhan Nair, Hengyuan Liu, Gabriele Ciceri, Johannes Jungverdorben, Goar Frishman, Jason Tchieu

Cell Stem Cell· September 2021

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Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability.
Xinzhu Deng, Jason Tchieu, Daniel S Higginson, Kuo-Shun Hsu, Regina Feldman

Cancer Res· July 2021

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Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease.
Sudha R Guttikonda, Lisa Sikkema, Jason Tchieu, Nathalie Saurat, Ryan M Walsh

Nat Neurosci· March 2021

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Introductions to the Community: Early-Career Researchers in the Time of COVID-19.
Jason Tchieu, Noelia Urbán, Alice Soragni, Kyogo Kawaguchi, Joel W Blanchard

Cell Stem Cell· October 2020

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A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes.
Gustav Y Cederquist, Jason Tchieu, Scott J Callahan, Kiran Ramnarine, Sean Ryan

Cell Stem Cell· July 2020

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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs.
Daniela Cornacchia, Chao Zhang, Bastian Zimmer, Sun Young Chung, Yujie Fan, Jason Tchieu

Cell Stem Cell· July 2019

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Specification of positional identity in forebrain organoids.
Gustav Y Cederquist, James J Asciolla, Jason Tchieu, Ryan M Walsh, Daniela Cornacchia

Nat Biotechnol· April 2019

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