Publications by authors named "Jason Weesner"

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Mitochondrial proteostasis regulated by CRL5 and Alix modulates skeletal muscle metabolism and fiber type.
Yvan Campos, Gustavo Palacios, Elida Gomero, Diantha van de Vlekkert, Krishnan Venkataraman, Jason Andrew Weesner

Commun Biol· December 2025

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Targeting Lysosomal Dysfunction to Alleviate Plaque Deposition in an Alzheimer Disease Model.
Leigh Ellen Fremuth, Diantha van de Vlekkert, Huimin Hu, Jason Andrew Weesner, Ida Annunziata

bioRxiv· May 2025

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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation.
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner

Cell Rep· January 2025

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Protocol for the isolation and purification of endoplasmic reticulum-plasma membrane junctions from the mouse brain.
Jason A Weesner, Diantha van de Vlekkert, Leigh Ellen Fremuth, Alessandra d'Azzo

STAR Protoc· September 2024

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AAV-mediated gene therapy for sialidosis.
Diantha van de Vlekkert, Huimin Hu, Jason A Weesner, Leigh E Fremuth, Scott A Brown

Mol Ther· July 2024

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Altered GM1 catabolism affects NMDAR-mediated Ca signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model.
Jason A Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G Robinson, Yvan Campos

Cell Rep· May 2024

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Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2.
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner

bioRxiv· May 2024

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AAV-mediated gene therapy for Sialidosis.
Diantha van de Vlekkert, Huimin Hu, Leigh E Fremuth, Scott A Brown, Jason A Weesner

bioRxiv· November 2023

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Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases.
Jason Andrew Weesner, Ida Annunziata, Diantha van de Vlekkert, Alessandra d'Azzo

FEBS Open Bio· September 2023

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Altered GM1 catabolism affects NMDAR-mediated Ca signaling at ER-PM junctions and increases synaptic spine formation.
Jason A Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G Robinson, Yvan Campos

bioRxiv· July 2023

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Distinct functions of dimeric and monomeric scaffold protein Alix in regulating F-actin assembly and loading of exosomal cargo.
Xiaohui Qiu, Yvan Campos, Diantha van de Vlekkert, Elida Gomero, Ajay C Tanwar, Jason A Weesner

J Biol Chem· October 2022

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Preclinical Enzyme Replacement Therapy with a Recombinant β-Galactosidase-Lectin Fusion for CNS Delivery and Treatment of GM1-Gangliosidosis.
Jason Andrew Weesner, Ida Annunziata, Tianhong Yang, Walter Acosta, Elida Gomero

Cells· August 2022

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AAV-mediated gene therapy for galactosialidosis: A long-term safety and efficacy study.
Huimin Hu, Rosario Mosca, Elida Gomero, Diantha van de Vlekkert, Yvan Campos, Jason A Weesner

Mol Ther Methods Clin Dev· December 2021

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Isolation of Mitochondria-Associated ER Membranes (MAMs), Synaptic MAMs, and Glycosphingolipid Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells.
Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azzo

Methods Mol Biol· July 2021

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Generation of human induced pluripotent stem cells (hIPSCs) from sialidosis types I and II patients with pathogenic neuraminidase 1 mutations.
Min-Joon Han, Ida Annunziata, Jason Weesner, Yvan Campos, Muneeb Salie

Stem Cell Res· July 2020

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Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice.
Aimee N Winter, Meena S Subbarayan, Bethany Grimmig, Jason A Weesner, Lauren Moss

J Neuroinflammation· May 2020

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